Database Query Results : , , Resistin

Resistin, Resistin: Click to Expand ⟱
Source:
Type:
Resistin is a pro-inflammatory adipokine (in humans produced mainly by macrophages/immune cells rather than adipocytes).
Levels are elevated in obesity, insulin resistance, and chronic inflammation.
In cancer biology, resistin is predominantly pro-tumorigenic, especially via inflammatory and metabolic reprogramming pathways.
Resistin is functionally upregulated in cancer and acts as a:
-Pro-inflammatory amplifier
-Metabolic dysregulator
-EMT and metastasis promoter
Its strongest relevance is in obesity- and inflammation-associated cancers, where it cooperates with leptin and insulin signaling while opposing irisin and adiponectin.


Scientific Papers found: Click to Expand⟱
5055- Ex,    Why exercise has a crucial role in cancer prevention, risk reduction and improved outcomes
- Review, Var, NA
OS↑, IGF-1↓, IGFBP3↑, BRCA1↑, BRCA2↑, RAS↓, P53↑, HSPs↑, Leptin↓, Irisin↓, Resistin↓, NK cell↑, CRP↓, IL6↓, TNF-α↓, PGE1↓, COX2↓, *GSH↑, *Catalase↑, *SOD↑, *monoA↑, *EndoR↑, *testos↑, ROS↑, QoL↑, BMD↑, BowelM↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

Irisin↓, 1,   Leptin↓, 1,   Resistin↓, 1,  

Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Transcription & Epigenetics ⓘ

BowelM↑, 1,  

Protein Folding & ER Stress ⓘ

HSPs↑, 1,  

DNA Damage & Repair ⓘ

BRCA1↑, 1,   BRCA2↑, 1,   P53↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

IGF-1↓, 1,   IGFBP3↑, 1,   RAS↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   CRP↓, 1,   IL6↓, 1,   NK cell↑, 1,   PGE1↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,   BRCA1↑, 1,   CRP↓, 1,   IL6↓, 1,  

Functional Outcomes ⓘ

OS↑, 1,   QoL↑, 1,  
Total Targets: 24

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

EndoR↑, 1,  

Redox & Oxidative Stress ⓘ

Catalase↑, 1,   GSH↑, 1,   SOD↑, 1,  

Synaptic & Neurotransmission ⓘ

monoA↑, 1,  

Hormonal & Nuclear Receptors ⓘ

testos↑, 1,  
Total Targets: 6

Scientific Paper Hit Count for: Resistin, Resistin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1423  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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