Database Query Results : , , GH

GH, Growth Hormone: Click to Expand ⟱
Source:
Type:
GH is secreted by the pituitary and also produced locally by many tumors (autocrine/paracrine GH).
Growth hormone signaling is pro-oncogenic when chronically elevated or locally produced by tumors, acting mainly through:
-IGF-1 → PI3K–AKT–mTOR
-JAK2–STAT5
-Angiogenesis and EMT support
It functions as a metabolic growth amplifier, especially in insulin-resistant and obesity-linked cancers.

Interventions (context-dependent):
-Caloric restriction / fasting
-Insulin sensitivity improvement
-mTOR / IGF-1R pathway inhibition (oncology settings)


Scientific Papers found: Click to Expand⟱
5065- dietSTF,  dietFMD,    Nutrition, GH/IGF-I Signaling, and Cancer
- Review, Var, NA
GH↓, IGF-1↓, glucose↓, IGFBP1↑, OS↑, Imm↑, neuroP↑, BMD↑, Dose↝, Risk↓, other↑, TumCP↓,
5231- Ex,    Regular Physical Exercise Increase Of Growth Hormone (GH) And Insulin-Like Growth Factor-1 (IGF-1) Activity in Elderly Improve the Aging Process and Quality of Life: A Mini Review
- Human, Nor, NA
*GH↑, *IGF-1↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

glucose↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

GH↓, 1,   IGF-1↓, 1,   IGFBP1↑, 1,  

Migration ⓘ

TumCP↓, 1,  

Immune & Inflammatory Signaling ⓘ

Imm↑, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,  

Functional Outcomes ⓘ

neuroP↑, 1,   OS↑, 1,   Risk↓, 1,  
Total Targets: 12

Pathway results for Effect on Normal Cells:


Proliferation, Differentiation & Cell State ⓘ

GH↑, 1,   IGF-1↑, 1,  
Total Targets: 2

Scientific Paper Hit Count for: GH, Growth Hormone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1426  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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