Database Query Results : , , CTSB

CTSB, Cathepsin B: Click to Expand ⟱
Source:
Type:
CTSB — Cathepsin B

Primary role: Lysosomal cysteine protease; executor of late-stage autophagic flux and mediator of lysosome-dependent cell death.

Cancer relevance:
CTSB is frequently overexpressed and mislocalized in cancer. In intact lysosomes, it enables productive autophagic flux by degrading autophagic cargo. Upon lysosomal membrane permeabilization (LMP), CTSB is released into the cytosol where it activates apoptotic signaling (including caspase-dependent and independent pathways). Extracellular CTSB promotes ECM degradation, invasion, and metastasis.

Net effect in established cancer:
Context-dependent, but predominantly pro-tumor via invasion and survival; pro-death when lysosomal integrity is lost.
Scientific Papers found: Click to Expand⟱
5173- Ash,  2DG,    Withaferin A inhibits lysosomal activity to block autophagic flux and induces apoptosis via energetic impairment in breast cancer cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468 - in-vitro, BC, T47D
autoF↓, lysosome↓, TumAuto↑, p‑LDH↓, ATP↓, AMPK↑, eff↑, TumCG↓, CTSD↓, CTSB↓, CTSL↑, cl‑PARP1↑, LDHA↓, TCA↓,
5124- Sal,    Inhibition of the autophagic flux by salinomycin in breast cancer stem-like/progenitor cells interferes with their maintenance
- in-vitro, BC, NA
CSCs↓, LC3II↑, other↓, lysosome↓, CTSZ↓, CTSB↓, CTSL↓, CTSS↓, autoF↓, TumAuto↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

ATP↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   p‑LDH↓, 1,   LDHA↓, 1,   TCA↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,  

Autophagy & Lysosomes ⓘ

autoF↓, 2,   LC3II↑, 1,   lysosome↓, 2,   TumAuto↓, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

cl‑PARP1↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   CTSB↓, 2,   CTSD↓, 1,   CTSL↓, 1,   CTSL↑, 1,   CTSS↓, 1,   TumCG↓, 1,  

Immune & Inflammatory Signaling ⓘ

CTSZ↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Clinical Biomarkers ⓘ

p‑LDH↓, 1,  
Total Targets: 22

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CTSB, Cathepsin B
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1429  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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