Database Query Results : , , CTSD

CTSD, Cathepsin D: Click to Expand ⟱
Source:
Type:
CTSD — Cathepsin D

Primary role: Lysosomal aspartyl protease; regulator of autophagic degradation and stress-adaptive survival signaling.

Cancer relevance:
CTSD supports lysosomal proteolysis and autophagic completion, enabling metabolic recycling under stress. In cancer, it is often overexpressed and can function both intracellularly (autophagy, apoptosis modulation) and extracellularly (growth factor processing). Partial lysosomal leakage of CTSD contributes to apoptotic signaling, while intact activity promotes therapy resistance.

Net effect in established cancer:
Predominantly pro-survival via maintenance of autophagic flux, with pro-apoptotic potential under severe stress.
Scientific Papers found: Click to Expand⟱
5173- Ash,  2DG,    Withaferin A inhibits lysosomal activity to block autophagic flux and induces apoptosis via energetic impairment in breast cancer cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-468 - in-vitro, BC, T47D
autoF↓, lysosome↓, TumAuto↑, p‑LDH↓, ATP↓, AMPK↑, eff↑, TumCG↓, CTSD↓, CTSB↓, CTSL↑, cl‑PARP1↑, LDHA↓, TCA↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

ATP↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   p‑LDH↓, 1,   LDHA↓, 1,   TCA↓, 1,  

Autophagy & Lysosomes ⓘ

autoF↓, 1,   lysosome↓, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

cl‑PARP1↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CTSB↓, 1,   CTSD↓, 1,   CTSL↑, 1,   TumCG↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Clinical Biomarkers ⓘ

p‑LDH↓, 1,  
Total Targets: 15

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CTSD, Cathepsin D
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1430  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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