Database Query Results : , , MethCyc

MethCyc, Methionine Cycle: Click to Expand ⟱
Source:
Type:
Methionine Cycle
Cancer cells are often methionine-addicted:
-Require high SAM flux
-Depend on methylation to sustain oncogenic transcription
-Have limited flexibility in remethylation pathways
This makes the methionine cycle a selective vulnerability.

Methionine uptake in Cancer ↑
Methionine Cycle (One-Carbon Metabolism): Central metabolic pathway converting dietary methionine into S-adenosylmethionine (SAM) to support DNA, RNA, and histone methylation, polyamine synthesis, and redox balance. Cancer cells exhibit methionine addiction with upregulation of MAT2A/MAT2B and high SAM demand, creating vulnerability to methionine restriction and one-carbon stress.
Scientific Papers found: Click to Expand⟱
5188- dietMet,    Dietary methionine links nutrition and metabolism to the efficacy of cancer therapies
- in-vivo, Var, NA
AntiAge↑, MethCyc↓, TumCG↓, ChemoSen↑, RadioS↑, OS↑, GSH↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GSH↓, 1,  

Core Metabolism/Glycolysis ⓘ

MethCyc↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   RadioS↑, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   OS↑, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: MethCyc, Methionine Cycle
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1442  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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