Database Query Results : , , HSP70/HSPA5

HSP70/HSPA5, heat shock proteins 70 kilodalton: Click to Expand ⟱
Source:
Type:
Also known as HSPA5
Enhanced expression of Hsp70 is associated with tumorigenesis for breast cancer, endometrial cancer, gastric cancer, and acute leukemia; with poor prognoses.
-These adenosine triphosphatases unfold misfolded or denatured proteins and can keep these proteins in an unfolded, folding-competent state. They also protect nascently translating proteins, promote the cellular or organellar transport of proteins, reduce proteotoxic protein aggregates and serve general housekeeping roles in maintaining protein homeostasis.
-HSP70 family of proteins can be thought of as a potent buffering system for cellular stress, either from extrinsic (physiological, viral and environmental) or intrinsic (replicative or oncogenic) stimuli. As such, this family serves a critical survival function in the cell. Not surprisingly, cancer cells rely heavily on this buffering system for survival. The overwhelming majority of human tumors overexpress HSP70 family members, and expression of these proteins is typically a marker for poor prognosis.
-HSP70 helps cancer cells survive under stressful conditions, such as hypoxia or nutrient deprivation, by preventing protein misfolding and aggregation. This allows cancer cells to maintain their proliferative capacity.
-Tumor Progression: Elevated levels of HSP70 have been associated with tumor progression and metastasis.
Scientific Papers found: Click to Expand⟱
2646- AL,    Anti-Cancer Potential of Homemade Fresh Garlic Extract Is Related to Increased Endoplasmic Reticulum Stress
- in-vitro, Pca, DU145 - in-vitro, Melanoma, RPMI-8226
AntiCan↑, eff↓, ChemoSen↑, ER Stress↑, tumCV↓, DNAdam↑, GSH∅, HSP70/HSPA5↓, UPR↑, β-catenin/ZEB1↓, ROS↑, HO-2↑, SIRT1↑, GlucoseCon∅, lactateProd∅, chemoP↑,
2657- AL,    Allicin pharmacology: Common molecular mechanisms against neuroinflammation and cardiovascular diseases
- Review, CardioV, NA - Review, AD, NA
*Inflam↓, *antiOx↑, *neuroP↑, *cardioP↑, *AntiTum↑, *mtDam↑, *HSP70/HSPA5↑, *NRF2↑, *RAAS↓, *cognitive↑, *SOD↑, *ROS↓, *NRF2↑, *ER Stress↓, *neuroP↑, *memory↑, *TBARS↓, *MPO↓, *SOD↑, *GSH↑, *iNOS↓, *p‑eNOS↑, *HO-1↑,
554- Anamu,    Petiveria alliacea extracts uses multiple mechanisms to inhibit growth of human and mouse tumoral cells
- in-vitro, NA, 769-P
TumCCA↑, HSP70/HSPA5↓, HSP90↓,
3345- ART/DHA,    Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells
- in-vitro, GBM, NA
ROS↑, Ferroptosis↑, lipid-P↑, HSP70/HSPA5↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MDA↑, GSH↓, eff↑, GPx4↑,
3383- ART/DHA,    Dihydroartemisinin: A Potential Natural Anticancer Drug
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, angioG↓, TumAuto↑, ER Stress↑, ROS↑, Ca+2↑, p38↑, HSP70/HSPA5↓, PPARγ↑, GLUT1↓, Glycolysis↓, PI3K↓, Akt↓, Hif1a↓, PKM2↓, lactateProd↓, GlucoseCon↓, EMT↓, Slug↓, Zeb1↓, ZEB2↓, Twist↓, Snail?, CAFs/TAFs↓, TGF-β↓, p‑STAT3↓, M2 MC↓, uPA↓, HH↓, AXL↓, VEGFR2↓, JNK↑, Beclin-1↑, GRP78/BiP↑, eff↑, eff↑, eff↑, eff↑, eff↑, eff↑, IL4↓, DR5↑, Cyt‑c↑, Fas↑, FADD↑, cl‑PARP↑, cycE/CCNE↓, CDK2↓, CDK4↓, Mcl-1↓, Ki-67↓, Bcl-2↓, CDK6↓, VEGF↓, COX2↓, MMP9↓,
1357- Ash,    Cytotoxicity of withaferin A in glioblastomas involves induction of an oxidative stress-mediated heat shock response while altering Akt/mTOR and MAPK signaling pathways
- in-vitro, GBM, U87MG - in-vitro, GBM, U251 - in-vitro, GBM, GL26
TumCP↓, TumCCA↑, Akt↓, mTOR↓, p70S6↓, p85S6K↓, AMPKα↑, TSC2↑, HSP70/HSPA5↑, HO-1↑, HSF1↓, Apoptosis↑, ROS↑, eff↓,
2003- Ash,    Withaferin A Induces Cell Death Selectively in Androgen-Independent Prostate Cancer Cells but Not in Normal Fibroblast Cells
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145 - in-vitro, Nor, TIG-1 - in-vitro, PC, LNCaP
TumCD↑, selectivity↑, cFos↑, ROS↑, *ROS∅, HSP70/HSPA5↑, Apoptosis↑, ER Stress↑, TumCCA↑,
2705- BBR,    Mechanism underlying berberine's effects on HSP70/TNFα under heat stress: Correlation with the TATA boxes
- in-vivo, Nor, NA - in-vitro, Nor, PC12
HSP70/HSPA5↓, TNF-α↓,
2685- BBR,    Berberine induces neuronal differentiation through inhibition of cancer stemness and epithelial-mesenchymal transition in neuroblastoma cells
- in-vitro, neuroblastoma, NA
CSCs↓, CD133↓, β-catenin/ZEB1↓, n-MYC↓, SOX2↓, NOTCH2↓, Nestin↓, TumCCA↑, TumCP↓, CDK1↓, Cyc↓, Apoptosis↑, Bax:Bcl2↑, NCAM↓, MMP2↓, MMP9↓, *Smad1↑, *HSP70/HSPA5↑, *LAMs↑,
2734- BetA,    Betulinic Acid Modulates the Expression of HSPA and Activates Apoptosis in Two Cell Lines of Human Colorectal Cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW480
tumCV↓, HSP70/HSPA5⇅, ROS↑, cl‑Casp3↑, mt-Apoptosis↑, Dose↝,
3516- Bor,    Boron in wound healing: a comprehensive investigation of its diverse mechanisms
- Review, Wounds, NA
*Inflam↓, *antiOx↑, *ROS↓, *angioG↑, *COL1↑, *α-SMA↑, *TGF-β↑, *BMD↑, *hepatoP↑, *TNF-α↑, *HSP70/HSPA5↑, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *TOS↓, *IL6↓, *JAK2↓, *STAT3↓, *AMPK↑, *lipid-P↓, *VEGF↑, *Half-Life↝,
738- Bor,    Borax induces ferroptosis of glioblastoma by targeting HSPA5/NRF2/GPx4/GSH pathways
- in-vitro, GBM, U251 - in-vitro, GBM, A172 - in-vitro, Nor, SVGp12
TumCP↓, GPx4↓, GSH↓, HSP70/HSPA5↓, NRF2↓, MDA↑, Casp3↑, Casp7↑, Ferroptosis↑, selectivity↑,
1652- CA,    Caffeic Acid and Diseases—Mechanisms of Action
- Review, Var, NA
Dose∅, ROS⇅, NF-kB↓, STAT3↓, VEGF↓, MMP9↓, HSP70/HSPA5↑, AST↝, ALAT↝, ALP↝, Hif1a↓, IL6↓, IGF-1R↓, P21↑, iNOS↓, ERK↓, Snail↓, BID↑, BAX↑, Casp3↑, Casp7↑, Casp9↑, cycD1/CCND1↓, Vim↓, β-catenin/ZEB1↓, COX2↓, ROS↑,
3791- CA,    Caffeic Acid and Diseases—Mechanisms of Action
- Review, AD, NA
*memory↑, *cognitive↑, *p‑tau↓, *ROS↓, *Inflam↓, *NF-kB↓, *Casp3↓, *lipid-P↓, *AChE↓, *BChE↓, *GSK‐3β↓, *5LO↓, *BDNF↓, VEGF↓, HSP70/HSPA5↓,
2016- CAP,    Capsaicin binds the N-terminus of Hsp90, induces lysosomal degradation of Hsp70, and enhances the anti-tumor effects of 17-AAG (Tanespimycin)
HSP90↓, ATPase↓, eff↑, HSP70/HSPA5↓, other↝, NF-kB↓, EGFR↓, CDK4↓, Src↓, VEGF↓, PI3K↓, Akt↓,
2807- CHr,    Evidence-based mechanistic role of chrysin towards protection of cardiac hypertrophy and fibrosis in rats
- in-vivo, Nor, NA
*antiOx↑, Inflam↓, *cardioP↑, *GSH↑, *SOD↑, *Catalase↑, *GAPDH↑, *BAX↓, *Bcl-2↑, *PARP↓, *Cyt‑c↓, *Casp3↓, *NOX4↓, *NRF2↑, *HO-1↑, *HSP70/HSPA5↑,
414- CUR,    Transcriptome Investigation and In Vitro Verification of Curcumin-Induced HO-1 as a Feature of Ferroptosis in Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
Ferroptosis↑, Iron↑, ROS↑, lipid-P↑, MDA↑, GSH↓, HO-1↑, NRF2↑, GPx↓, ROS↑, Iron↑, GPx4↓, HSP70/HSPA5↑, ATFs↑, CHOP↑, MDA↑, FTL↑, FTH1↑, BACH1↑, REL↑, USF1↑, NFE2L2↑,
467- CUR,    Curcumin inhibits liver cancer by inhibiting DAMP molecule HSP70 and TLR4 signaling
- in-vitro, Liver, HepG2
TumCP↓, TumCI↓, TumMeta↓, Apoptosis↑, HSP70/HSPA5↓, e-HSP70/HSPA5↓, TLR4↓,
4685- EGCG,    Epigallocathechin gallate, polyphenol present in green tea, inhibits stem-like characteristics and epithelial-mesenchymal transition in nasopharyngeal cancer cell lines
- in-vitro, NPC, TW01 - in-vitro, NPC, TW06
CSCs↓, EMT↓, TumCMig↓, TumCI↓, OCT4↓, Snail↓, Vim↓, E-cadherin↓, HSP70/HSPA5↓, HSP90↓, AntiTum↓,
3712- FA,    Ferulic Acid: A Hope for Alzheimer’s Disease Therapy from Plants
- Review, AD, NA
*antiOx↑, *Inflam↓, *ROS↓, *Aβ↓, *HO-1↑, *HSP70/HSPA5↑, *ERK↑, *Akt↑, *iNOS↓, *COX2↓, *cardioP↑, *memory↑, *IL2↓, *cognitive↑, *APP↓, *SOD↑, *Catalase↑, *Akt↑, *BioAv↑,
2845- FIS,    Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, p38↓, *antiOx↑, *neuroP↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, DNAdam↑, MMP↓, eff↑, ROS↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, P53↑, p65↓, Myc↓, HSP70/HSPA5↓, HSP27↓, COX2↓, Wnt↓, EGFR↓, NF-kB↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycA1/CCNA1↓, P21↑, MMP2↓, MMP9↓, TumMeta↓, MMP1↓, MMP3↓, MMP7↓, MET↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↑, uPA↓, ChemoSen↑, EMT↓, Twist↓, Zeb1↓, cFos↓, cJun↓, EGF↓, angioG↓, VEGF↓, eNOS↓, *NRF2↑, HO-1↑, NRF2↓, GSTs↓, ATF4↓,
2857- FIS,    A review on the chemotherapeutic potential of fisetin: In vitro evidences
- Review, Var, NA
COX2↓, PGE2↓, EGFR↓, Wnt↓, β-catenin/ZEB1↓, TCF↑, Apoptosis↑, Casp3↑, cl‑PARP↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, Akt↓, mTOR↓, ACC↑, Cyt‑c↑, Diablo↑, cl‑Casp8↑, Fas↑, DR5↑, TRAIL↑, Securin↓, CDC2↓, CDC25↓, HSP70/HSPA5↓, CDK2↓, CDK4↓, cycD1/CCND1↓, MMP2↓, uPA↓, NF-kB↓, cFos↓, cJun↓, MEK↓, p‑ERK↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↓, NF-kB↑, ROS↑, DNAdam↑, MMP↓, CHOP↑, eff↑, ChemoSen↑,
2825- FIS,    Exploring the molecular targets of dietary flavonoid fisetin in cancer
- Review, Var, NA
*Inflam↓, *antiOx↓, *ERK↑, *p‑cMyc↑, *NRF2↑, *GSH↑, *HO-1↑, mTOR↓, PI3K↓, Akt↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27↑, JNK↑, MMP2↓, MMP9↓, uPA↓, NF-kB↓, cFos↓, cJun↓, E-cadherin↑, Vim↓, N-cadherin↓, EMT↓, MMP↓, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, P53↑, COX2↓, PGE2↓, HSP70/HSPA5↓, HSP27↓, DNAdam↑, Casp3↑, Casp9↑, ROS↑, AMPK↑, NO↑, Ca+2↑, mTORC1↓, p70S6↓, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, Half-Life↝,
2843- FIS,    Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential
- Review, Var, NA
NRF2↑, Keap1↓, ChemoSen↑, BioAv↓, Cyt‑c↑, Casp3↑, Casp9↑, BAX↑, tumCV↓, Mcl-1↓, cl‑PARP↑, IGF-1↓, Akt↓, CDK6↓, TumCCA↑, P53?, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, MMP2↓, MMP9↓, MMP1↓, MMP7↓, MMP3↓, VEGF↓, PI3K↓, mTOR↓, COX2↓, Wnt↓, EGFR↓, NF-kB↓, ERK↓, ROS↑, angioG↓, TNF-α↓, PGE2↓, iNOS↓, NO↓, IL6↓, HSP70/HSPA5↝, HSP27↝,
839- Gra,    Functional proteomic analysis revels that the ethanol extract of Annona muricata L. induces liver cancer cell apoptosis through endoplasmic reticulum stress pathway
- in-vitro, Liver, HepG2
tumCV↓, Apoptosis↑, HSP70/HSPA5↑, GRP94↑, ER Stress↑, p‑PERK↑, p‑eIF2α↑, GRP78/BiP↑, CHOP↑,
2531- M-Blu,    Anticancer activity of methylene blue via inhibition of heat shock protein 70
- in-vitro, Lung, A549 - in-vivo, NA, NA
tumCV↓, HSP70/HSPA5↓, LDH↓, SOD↑,
2253- MF,    Low-frequency pulsed electromagnetic field promotes functional recovery, reduces inflammation and oxidative stress, and enhances HSP70 expression following spinal cord injury
- in-vivo, Nor, NA
*Inflam↓, *TNF-α↓, *IL1β↓, *NF-kB↓, *iNOS↓, *ROS↓, Catalase↑, *SOD↑, *HSP70/HSPA5↑, *neuroP↑, *motorD↑, *antiOx↑,
2256- MF,  HPT,    Effects of exposure to repetitive pulsed magnetic stimulation on cell proliferation and expression of heat shock protein 70 in normal and malignant cells
- in-vitro, BC, MCF-7 - in-vitro, Cerv, HeLa - in-vitro, Nor, HBL-100
HSP70/HSPA5↑, HSP70/HSPA5∅,
2255- MF,    Pulsed Electromagnetic Fields Induce Skeletal Muscle Cell Repair by Sustaining the Expression of Proteins Involved in the Response to Cellular Damage and Oxidative Stress
- in-vitro, Nor, SkMC
*HSP70/HSPA5↑, *Apoptosis↓, *Inflam↓, *Trx↓, *PONs↓, *SOD2↓, *TumCG↑, *Diff↑, *HIF2a↑, *Cyt‑c↑, P21↑,
2254- MF,    Effect of 60 Hz electromagnetic fields on the activity of hsp70 promoter: an in vivo study
- in-vivo, Nor, NA
*HSP70/HSPA5↑, HSP70/HSPA5↑,
3469- MF,    Pulsed Electromagnetic Fields (PEMF)—Physiological Response and Its Potential in Trauma Treatment
- Review, NA, NA
*eff↑, *eff↝, *other↑, Ca+2↑, ROS↑, HSP70/HSPA5↑, *NOTCH↑, *HEY1↑, *p38↑, *MAPK↑,
4105- MF,    Extremely low frequency electromagnetic fields stimulation modulates autoimmunity and immune responses: a possible immuno-modulatory therapeutic effect in neurodegenerative diseases
- Review, AD, NA
*Inflam↓, *neuroP↑, *NO↑, *ROS↓, *NO↓, *MCP1↑, *HSP70/HSPA5↑, *antiOx↑, *NRF2↑, *NF-kB↓,
4116- MF,    Low‑frequency pulsed electromagnetic field promotes functional recovery, reduces inflammation and oxidative stress, and enhances HSP70 expression following spinal cord injury
- in-vivo, NA, NA
*Inflam↓, *TNF-α↓, *IL1β↓, *iNOS↓, *ROS↓, *Catalase↑, *SOD↑, HSP70/HSPA5↑,
493- MF,    Extremely low-frequency electromagnetic field induces acetylation of heat shock proteins and enhances protein folding
- in-vitro, NA, HEK293 - in-vitro, Liver, AML12
ATP↑, HSP70/HSPA5↓, HSP90↓,
526- MF,    Inhibition of Cancer Cell Growth by Exposure to a Specific Time-Varying Electromagnetic Field Involves T-Type Calcium Channels
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7 - in-vitro, Pca, HeLa - vitro+vivo, Melanoma, B16-BL6 - in-vitro, Nor, HEK293
TumCG↓, Ca+2↑, selectivity↑, *Ca+2∅, ROS↑, HSP70/HSPA5↑, AntiCan↑,
492- MF,    Weak electromagnetic fields (50 Hz) elicit a stress response in human cells
- in-vitro, AML, HL-60
HSP70/HSPA5↑,
524- MF,    Inhibition of Angiogenesis Mediated by Extremely Low-Frequency Magnetic Fields (ELF-MFs)
- vitro+vivo, PC, MS-1 - vitro+vivo, PC, HUVECs
other↓, TumCP↓, TumCMig↓, VEGFR2↓, TumVol↓, HSP70/HSPA5↓, HSP90↓, TumCCA↑, angioG↓,
519- MF,    Effects of 50-Hz magnetic field exposure on superoxide radical anion formation and HSP70 induction in human K562 cells
- in-vitro, AML, K562
HSP70/HSPA5↑,
194- MF,    Electromagnetic Field as a Treatment for Cerebral Ischemic Stroke
- Review, Stroke, NA
*BAD↓, *BAX↓, *Casp3↓, *Bcl-xL↑, *p‑Akt↑, *MMP9↓, *p‑ERK↑, *HIF-1↓, *ROS↓, *VEGF↑, *Ca+2↓, *SOD↑, *IL2↑, *p38↑, *HSP70/HSPA5↑, *Apoptosis↓, *ROS↓, *NO↓,
3249- PBG,    Can Propolis Be a Useful Adjuvant in Brain and Neurological Disorders and Injuries? A Systematic Scoping Review of the Latest Experimental Evidence
- Review, Var, NA
*Inflam↓, *ROS↓, *MDA↓, *TNF-α↓, *NO↓, *iNOS↓, *SOD↑, *GPx↑, *GSR↓, *GSH↑, *neuroP↑, *IL6↓, *MMP2↓, *MMP9↓, *MCP1↓, *HSP70/HSPA5↑, *motorD↑, *Pain↓, *VCAM-1↓, *NF-kB↓, *MAPK↓, *JNK↓, *IL1β↓, *AChE↓, *toxicity∅, cognitive↑,
3343- QC,    Quercetin, a Flavonoid with Great Pharmacological Capacity
- Review, Var, NA - Review, AD, NA - Review, Arthritis, NA
*antiOx↑, *ROS↓, *angioG↓, *Inflam↓, *BioAv↓, *Half-Life↑, *GSH↑, *SOD↑, *Catalase↑, *Nrf1↑, *BP↓, *cardioP↑, *IL10↓, *TNF-α↓, *Aβ↓, *GSK‐3β↓, *tau↓, *neuroP↑, *Pain↓, *COX2↓, *NRF2↑, *HO-1↑, *IL1β↓, *IL17↓, *MCP1↓, PKCδ↓, ERK↓, BAX↓, cMyc↓, KRAS↓, ROS↓, selectivity↑, tumCV↓, Apoptosis↑, TumCCA↑, eff↑, P-gp↓, eff↑, eff↑, eff↑, eff↑, CycB/CCNB1↓, CDK1↓, CDK4↓, CDK2↓, TOP2↓, Cyt‑c↑, cl‑PARP↑, MMP↓, HSP70/HSPA5↓, HSP90↓, MDM2↓, RAS↓, eff↑,
3369- QC,    Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
- Review, Pca, NA
FAK↓, TumCCA↑, p‑pRB↓, CDK2↑, CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt↓, ROS↑, miR-21↑, Akt↓, NF-kB↓, FasL↑, Bak↑, BAX↑, Bcl-2↓, Casp3↓, Casp9↑, P53↑, p38↑, MAPK↑, Cyt‑c↑, PARP↓, CHOP↑, ROS↓, LDH↑, GRP78/BiP↑, ERK↑, MDA↓, SOD↑, GSH↑, NRF2↑, VEGF↓, PDGF↓, EGF↓, FGF↓, TNF-α↓, TGF-β↓, VEGFR2↓, EGFR↓, FGFR1↓, mTOR↓, cMyc↓, MMPs↓, LC3B-II↑, Beclin-1↑, IL1β↓, CRP↓, IL10↓, COX2↓, IL6↓, TLR4↓, Shh↓, HER2/EBBR2↓, NOTCH↓, DR5↑, HSP70/HSPA5↓, CSCs↓, angioG↓, MMP2↓, MMP9↓, IGFBP3↑, uPA↓, uPAR↓, RAS↓, Raf↓, TSP-1↑,
94- QC,  HPT,    Effects of quercetin on the heat-induced cytotoxicity of prostate cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, PC3 - in-vitro, Pca, JCA-1
HSP70/HSPA5↓,
2566- RES,    A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke
- Review, Stroke, NA
*neuroP↑, *NRF2↑, *SIRT1↑, *PGC-1α↑, *FOXO↑, *HO-1↑, *NQO1↑, *ROS↓, *BP↓, *BioAv↓, *Half-Life↝, *AMPK↑, *GSK‐3β↓, *eff↑, *AntiAg↑, *BBB↓, *Inflam↓, *MPO↓, *TLR4↓, *NF-kB↓, *p65↓, *MMP9↓, *TNF-α↓, *IL1β↓, *PPARγ↑, *MMP↑, *ATP↑, *Cyt‑c∅, *mt-lipid-P↓, *H2O2↓, *HSP70/HSPA5↝, *Mets↝, *eff↑, *eff↑, *motorD↑, *MDA↓, *NADH:NAD↑, eff↑, eff↑,
3490- RF,    Multidimensional insights into the repeated electromagnetic field stimulation and biosystems interaction in aging and age-related diseases
- Review, AD, NA - Review, Park, NA
*OS↑, *memory↑, *cognitive↑, *memory↑, *Aβ↓, *eff↑, *HSF1↑, *HSP70/HSPA5↑,
3002- RosA,    Anticancer Effects of Rosemary (Rosmarinus officinalis L.) Extract and Rosemary Extract Polyphenols
- Review, Var, NA
TumCG↓, TumCP↓, TumCCA↑, ChemoSen↑, NRF2↑, PERK↑, SESN2↑, HO-1↑, cl‑Casp3↑, ROS↑, UPR↑, ER Stress↑, CHOP↑, HER2/EBBR2↓, ER-α36↓, PSA↓, BAX↑, AR↓, P-gp↓, Cyt‑c↑, HSP70/HSPA5↑, eff↑, p‑Akt↓, p‑mTOR↓, p‑P70S6K↓, cl‑PARP↑, eff↑,
3664- SFN,    Sulforaphane Upregulates the Heat Shock Protein Co-Chaperone CHIP and Clears Amyloid-β and Tau in a Mouse Model of Alzheimer's Disease
- in-vivo, AD, NA
*CHIP↑, *HSP70/HSPA5↑, *Aβ↓, *tau↓,
3663- SFN,    Efficacy of Sulforaphane in Neurodegenerative Diseases
- Review, AD, NA - Review, Park, NA
*antiOx↑, *Inflam↓, *Half-Life↝, *NRF2↑, *NQO1↑, *HO-1↑, *TrxR↑, *ROS↓, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2↓, *Aβ↓, *GSH↑, *cognitive↑, *BACE↓, *HSP70/HSPA5↑, *neuroP↑, *ROS↓, *BBB↑, *MMP9↓,
3658- SFN,    Pre-Clinical Neuroprotective Evidences and Plausible Mechanisms of Sulforaphane in Alzheimer’s Disease
- Review, AD, NA
*NRF2↑, *antiOx↑, *neuroP↑, *Aβ↓, *BACE↓, *NQO1↑, *IL1β↓, *TNF-α↓, *IL6↓, *COX2↓, *iNOS↓, *NF-kB↓, *NLRP3↓, *Ca+2↓, *GSH↑, *MDA↓, *ROS↓, *SOD↑, *HO-1↑, *TrxR↑, *cognitive↑, *tau↓, *HSP70/HSPA5↑,
1726- SFN,    Sulforaphane: A Broccoli Bioactive Phytocompound with Cancer Preventive Potential
- Review, Var, NA
Dose↝, eff↝, IL1β↓, IL6↓, IL12↓, TNF-α↓, COX2↓, CXCR4↓, MPO↓, HSP70/HSPA5↓, HSP90↓, VCAM-1↓, IKKα↓, NF-kB↓, HO-1↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, CHOP↑, survivin↓, XIAP↓, p38↑, Fas↑, PUMA↑, VEGF↓, Hif1a↓, Twist↓, Zeb1↓, Vim↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Snail↓, CD44↓, cycD1/CCND1↓, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDK4↓, CDK6↓, p50↓, P53↑, P21↑, GSH↑, SOD↑, GSTs↑, mTOR↓, Akt↓, PI3K↓, β-catenin/ZEB1↓, IGF-1↓, cMyc↓, CSCs↓,
1050- SK,    Shikonin improves the effectiveness of PD-1 blockade in colorectal cancer by enhancing immunogenicity via Hsp70 upregulation
- in-vitro, Colon, CT26
HSP70/HSPA5↑, ROS↑, PKM2↓,
2091- TQ,    Determination of anti-cancer effects of Nigella sativa seed oil on MCF7 breast and AGS gastric cancer cells
- in-vitro, BC, MCF-7 - in-vitro, GC, AGS
Dose↝, Casp3↑, Bcl-2↓, MMP2↓, MMP9↓, HSP70/HSPA5↓,
2084- TQ,    Thymoquinone, as an anticancer molecule: from basic research to clinical investigation
- Review, Var, NA
*ROS↓, *chemoPv↑, ROS↑, ROS⇅, MUC4↓, selectivity↑, AR↓, cycD1/CCND1↓, Bcl-2↓, Bcl-xL↓, survivin↓, Mcl-1↓, VEGF↓, cl‑PARP↑, ROS↑, HSP70/HSPA5↑, P53↑, miR-34a↑, Rac1↓, TumCCA↑, NOTCH↓, NF-kB↓, IκB↓, p‑p65↓, IAP1↓, IAP2↑, XIAP↓, TNF-α↓, COX2↓, Inflam↓, α-tubulin↓, Twist↓, EMT↓, mTOR↓, PI3K↓, Akt↓, BioAv↓, ChemoSen↑, BioAv↑, PTEN↑, chemoPv↑, RadioS↑, *Half-Life↝, *BioAv↝,
2109- TQ,    Thymoquinone Induces Mitochondria-Mediated Apoptosis in Acute Lymphoblastic Leukaemia in Vitro
- in-vitro, AML, CEM
Apoptosis↓, Bcl-2↓, BAX↑, ROS↑, HSP70/HSPA5↑, Casp3↑, Casp8↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 54

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

chemoPv↑, 1,  

Redox & Oxidative Stress ⓘ

Catalase↑, 1,   Ferroptosis↑, 3,   GPx↓, 1,   GPx4↓, 2,   GPx4↑, 1,   GSH↓, 3,   GSH↑, 2,   GSH∅, 1,   GSTs↓, 1,   GSTs↑, 1,   HO-1↑, 5,   HO-2↑, 1,   Iron↑, 2,   Keap1↓, 1,   lipid-P↑, 2,   MDA↓, 1,   MDA↑, 4,   MPO↓, 1,   NFE2L2↑, 1,   NRF2↓, 2,   NRF2↑, 4,   ROS↓, 3,   ROS↑, 21,   ROS⇅, 2,   SOD↑, 3,  

Metal & Cofactor Biology ⓘ

FTH1↑, 1,   FTL↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   CDC2↓, 1,   CDC25↓, 1,   EGF↓, 2,   FGFR1↓, 1,   MEK↓, 1,   MMP↓, 4,   Raf↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

ACC↑, 2,   ALAT↝, 1,   AMPK↑, 2,   cMyc↓, 3,   GlucoseCon↓, 1,   GlucoseCon∅, 1,   Glycolysis↓, 1,   lactateProd↓, 1,   lactateProd∅, 1,   LDH↓, 1,   LDH↑, 1,   PKM2↓, 2,   PPARγ↑, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↓, 10,   p‑Akt↓, 1,   Apoptosis↓, 1,   Apoptosis↑, 8,   mt-Apoptosis↑, 1,   BAD↑, 2,   Bak↑, 1,   BAX↓, 1,   BAX↑, 7,   Bax:Bcl2↑, 1,   Bcl-2↓, 7,   Bcl-xL↓, 1,   BID↑, 1,   BIM↑, 2,   Casp↑, 1,   Casp3↓, 1,   Casp3↑, 9,   cl‑Casp3↑, 2,   Casp7↑, 3,   Casp8↑, 2,   cl‑Casp8↑, 1,   Casp9↑, 5,   Cyt‑c↑, 9,   Diablo↑, 4,   DR5↑, 3,   FADD↑, 1,   Fas↑, 3,   FasL↑, 1,   Ferroptosis↑, 3,   IAP1↓, 1,   IAP2↑, 1,   iNOS↓, 2,   JNK↑, 2,   MAPK↓, 1,   MAPK↑, 1,   Mcl-1↓, 5,   MDM2↓, 1,   Myc↓, 1,   p27↑, 1,   p38↓, 1,   p38↑, 3,   PUMA↑, 1,   survivin↓, 2,   TRAIL↑, 1,   TumCD↑, 1,  

Kinase & Signal Transduction ⓘ

AMPKα↑, 1,   HER2/EBBR2↓, 2,   p70S6↓, 2,   TSC2↑, 1,  

Transcription & Epigenetics ⓘ

cJun↓, 3,   miR-21↑, 1,   other↓, 1,   other↝, 1,   p‑pRB↓, 1,   tumCV↓, 6,   USF1↑, 1,  

Protein Folding & ER Stress ⓘ

ATFs↑, 1,   CHOP↑, 6,   p‑eIF2α↑, 1,   ER Stress↑, 7,   GRP78/BiP↑, 5,   GRP94↑, 1,   HSF1↓, 1,   HSP27↓, 2,   HSP27↝, 1,   HSP70/HSPA5↓, 20,   HSP70/HSPA5↑, 17,   HSP70/HSPA5⇅, 1,   HSP70/HSPA5↝, 1,   HSP70/HSPA5∅, 1,   e-HSP70/HSPA5↓, 1,   HSP90↓, 7,   IRE1↑, 1,   PERK↑, 1,   p‑PERK↑, 1,   UPR↑, 2,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 2,   LC3B-II↑, 1,   SESN2↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 4,   P53?, 1,   P53↑, 5,   PARP↓, 1,   cl‑PARP↑, 9,  

Cell Cycle & Senescence ⓘ

CDK1↓, 3,   CDK2↓, 6,   CDK2↑, 1,   CDK4↓, 8,   Cyc↓, 1,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 7,   cycE/CCNE↓, 4,   P21↑, 5,   Securin↓, 1,   TumCCA↑, 12,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   CD44↓, 1,   cFos↓, 3,   cFos↑, 1,   CSCs↓, 4,   EMT↓, 6,   ERK↓, 3,   ERK↑, 1,   p‑ERK↓, 1,   FGF↓, 1,   HH↓, 1,   IGF-1↓, 2,   IGF-1R↓, 1,   IGFBP3↑, 1,   miR-34a↑, 1,   mTOR↓, 8,   p‑mTOR↓, 1,   mTORC1↓, 1,   n-MYC↓, 1,   Nestin↓, 1,   NOTCH↓, 2,   NOTCH2↓, 1,   OCT4↓, 1,   p‑P70S6K↓, 1,   p85S6K↓, 1,   PI3K↓, 8,   PTEN↑, 1,   RAS↓, 2,   Shh↓, 1,   SOX2↓, 1,   Src↓, 1,   STAT3↓, 1,   p‑STAT3↓, 1,   TCF↑, 1,   TOP2↓, 1,   TumCG↓, 2,   Wnt↓, 4,  

Migration ⓘ

ATPase↓, 1,   AXL↓, 1,   BACH1↑, 1,   Ca+2↑, 4,   CAFs/TAFs↓, 1,   E-cadherin↓, 2,   E-cadherin↑, 3,   ER-α36↓, 1,   FAK↓, 1,   Fibronectin↓, 2,   Ki-67↓, 1,   KRAS↓, 1,   MET↓, 1,   MMP1↓, 2,   MMP2↓, 8,   MMP3↓, 2,   MMP7↓, 2,   MMP9↓, 9,   MMPs↓, 1,   MUC4↓, 1,   N-cadherin↓, 4,   NCAM↓, 1,   PDGF↓, 1,   PKCδ↓, 1,   Rac1↓, 1,   Slug↓, 1,   Snail?, 1,   Snail↓, 5,   TGF-β↓, 2,   TSP-1↑, 1,   TumCI↓, 2,   TumCMig↓, 2,   TumCP↓, 7,   TumMeta↓, 3,   Twist↓, 4,   uPA↓, 5,   uPAR↓, 1,   VCAM-1↓, 1,   Vim↓, 6,   Zeb1↓, 3,   ZEB2↓, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 5,  

Angiogenesis & Vasculature ⓘ

angioG↓, 5,   ATF4↓, 1,   ATF4↑, 2,   EGFR↓, 5,   eNOS↓, 1,   Hif1a↓, 3,   NO↓, 1,   NO↑, 1,   REL↑, 1,   VEGF↓, 9,   VEGFR2↓, 3,  

Barriers & Transport ⓘ

GLUT1↓, 1,   P-gp↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 9,   CRP↓, 1,   CXCR4↓, 1,   IKKα↓, 1,   IL10↓, 1,   IL12↓, 1,   IL1β↓, 2,   IL4↓, 1,   IL6↓, 4,   Inflam↓, 2,   IκB↓, 1,   M2 MC↓, 1,   NF-kB↓, 9,   NF-kB↑, 1,   p50↓, 1,   p65↓, 1,   p‑p65↓, 1,   PGE2↓, 3,   PSA↓, 1,   TLR4↓, 2,   TNF-α↓, 5,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 2,   CDK6↓, 5,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 1,   ChemoSen↑, 7,   Dose↝, 3,   Dose∅, 1,   eff↓, 2,   eff↑, 23,   eff↝, 1,   Half-Life↝, 1,   RadioS↑, 2,   selectivity↑, 5,  

Clinical Biomarkers ⓘ

ALAT↝, 1,   ALP↝, 1,   AR↓, 2,   AST↝, 1,   CRP↓, 1,   EGFR↓, 5,   HER2/EBBR2↓, 2,   IL6↓, 4,   Ki-67↓, 1,   KRAS↓, 1,   LDH↓, 1,   LDH↑, 1,   Myc↓, 1,   PSA↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   AntiTum↓, 1,   chemoP↑, 1,   cognitive↑, 1,   TumVol↓, 1,  
Total Targets: 294

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

chemoPv↑, 1,  

Redox & Oxidative Stress ⓘ

antiOx↓, 1,   antiOx↑, 10,   Catalase↑, 5,   GPx↑, 1,   GSH↑, 8,   GSR↓, 1,   H2O2↓, 1,   HO-1↑, 8,   lipid-P↓, 2,   mt-lipid-P↓, 1,   MDA↓, 4,   Mets↝, 1,   MPO↓, 2,   NOX4↓, 1,   NQO1↑, 3,   Nrf1↑, 1,   NRF2↑, 10,   ROS↓, 16,   ROS∅, 1,   SOD↑, 11,   SOD2↓, 1,   TBARS↓, 1,   TOS↓, 1,   Trx↓, 1,   TrxR↑, 2,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 1,   MMP↑, 1,   mtDam↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 2,   p‑cMyc↑, 1,   GAPDH↑, 1,   NADH:NAD↑, 1,   PONs↓, 1,   PPARγ↑, 1,   SIRT1↑, 1,  

Cell Death ⓘ

Akt↑, 2,   p‑Akt↑, 1,   Apoptosis↓, 2,   BAD↓, 1,   BAX↓, 2,   Bcl-2↑, 1,   Bcl-xL↑, 1,   Casp3↓, 3,   Cyt‑c↓, 1,   Cyt‑c↑, 1,   Cyt‑c∅, 1,   HEY1↑, 1,   iNOS↓, 7,   JNK↓, 1,   MAPK↓, 1,   MAPK↑, 1,   p38↑, 2,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,   HSF1↑, 1,   HSP70/HSPA5↑, 15,   HSP70/HSPA5↝, 1,  

DNA Damage & Repair ⓘ

PARP↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

CHIP↑, 1,   Diff↑, 1,   ERK↑, 2,   p‑ERK↑, 1,   FOXO↑, 1,   GSK‐3β↓, 3,   NOTCH↑, 1,   STAT3↓, 1,   TumCG↑, 1,  

Migration ⓘ

5LO↓, 1,   AntiAg↑, 1,   APP↓, 1,   Ca+2↓, 2,   Ca+2∅, 1,   COL1↑, 1,   LAMs↑, 1,   MMP2↓, 1,   MMP9↓, 4,   Smad1↑, 1,   TGF-β↑, 1,   VCAM-1↓, 1,   α-SMA↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   angioG↑, 1,   p‑eNOS↑, 1,   HIF-1↓, 1,   HIF2a↑, 1,   NO↓, 3,   NO↑, 1,   VEGF↑, 2,  

Barriers & Transport ⓘ

BBB↓, 1,   BBB↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 4,   IL10↓, 1,   IL17↓, 1,   IL1β↓, 7,   IL2↓, 1,   IL2↑, 1,   IL6↓, 4,   Inflam↓, 13,   JAK2↓, 1,   MCP1↓, 2,   MCP1↑, 1,   NF-kB↓, 6,   p65↓, 1,   TLR4↓, 1,   TNF-α↓, 7,   TNF-α↑, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 2,   BChE↓, 1,   BDNF↓, 1,   tau↓, 3,   p‑tau↓, 1,  

Protein Aggregation ⓘ

Aβ↓, 6,   BACE↓, 2,   NLRP3↓, 1,  

Hormonal & Nuclear Receptors ⓘ

RAAS↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 1,   BioAv↝, 1,   eff↑, 5,   eff↝, 1,   Half-Life↑, 1,   Half-Life↝, 4,  

Clinical Biomarkers ⓘ

BMD↑, 1,   BP↓, 2,   IL6↓, 4,  

Functional Outcomes ⓘ

AntiTum↑, 1,   cardioP↑, 4,   cognitive↑, 6,   hepatoP↑, 1,   memory↑, 5,   motorD↑, 3,   neuroP↑, 10,   OS↑, 1,   Pain↓, 2,   toxicity∅, 1,  
Total Targets: 137

Scientific Paper Hit Count for: HSP70/HSPA5, heat shock proteins 70 kilodalton
13 Magnetic Fields
4 Fisetin
4 Sulforaphane (mainly Broccoli)
3 Quercetin
3 Thymoquinone
2 Allicin (mainly Garlic)
2 Artemisinin
2 Ashwagandha(Withaferin A)
2 Berberine
2 Boron
2 Caffeic acid
2 Curcumin
2 Hyperthermia
1 dibenzyl trisulphide(DTS) from Anamu
1 Betulinic acid
1 Capsaicin
1 Chrysin
1 EGCG (Epigallocatechin Gallate)
1 Ferulic acid
1 Graviola
1 Methylene blue
1 Propolis -bee glue
1 Resveratrol
1 Radio Frequency
1 Rosmarinic acid
1 Shikonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:148  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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