Database Query Results : , , IDH2

IDH2, isocitrate dehydrogenase 2 (NADP+), mitochondrial: Click to Expand ⟱
Source: CGL-Driver Genes
Type: Oncogene
An enzyme that plays a crucial role in the citric acid cycle (Krebs cycle), which is essential for cellular metabolism. Mutations in the IDH2 gene have been implicated in various types of cancer, particularly in hematological malignancies such as acute myeloid leukemia (AML) and certain brain tumors like gliomas.
IDH2 mutations often lead to a gain of function, resulting in the production of 2-hydroxyglutarate (2-HG), an oncometabolite. Elevated levels of 2-HG can disrupt normal cellular processes, including DNA and histone methylation, leading to altered gene expression and promoting tumorigenesis.

IDH2 (Isocitrate Dehydrogenase 2) is another enzyme involved in cellular metabolism, similar to IDH1. It is primarily located in the mitochondria and plays a role in the citric acid cycle. Mutations in the IDH2 gene are associated with various cancers, particularly acute myeloid leukemia (AML) and some solid tumors.


Scientific Papers found: Click to Expand⟱
1991- Part,    A novel SLC25A1 inhibitor, parthenolide, suppresses the growth and stemness of liver cancer stem cells with metabolic vulnerability
- in-vitro, Liver, HUH7
TumCCA↑, Apoptosis↑, CSCs↓, ROS↑, OXPHOS↓, MMP↓, SLC25A1↓, IDH2↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

OXPHOS↓, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

IDH2↓, 1,   SLC25A1↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: IDH2, isocitrate dehydrogenase 2 (NADP+), mitochondrial
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:153  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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