Database Query Results : , , KDM6A

KDM6A, lysine (K)-specific demethylase 6A: Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
KDM6A (Lysine Demethylase 6A) is a gene that encodes a protein involved in the regulation of gene expression through the demethylation of histone proteins. It plays a crucial role in epigenetic regulation, which is the process by which gene activity is regulated without changes to the underlying DNA sequence.
KDM6A is often considered a tumor suppressor gene. Loss of function mutations or deletions of KDM6A have been observed in several cancers, including bladder cancer, lung cancer, and certain hematological malignancies.
In many cancers, KDM6A is often downregulated or mutated, leading to a loss of its demethylase activity. This downregulation can result in the accumulation of repressive histone marks, such as H3K27me3, which can silence tumor suppressor genes and promote oncogenic pathways.
Scientific Papers found: Click to Expand⟱

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 0

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: KDM6A, lysine (K)-specific demethylase 6A
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:171  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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