Database Query Results : , , Macrophages

Macrophages, Macrophages: Click to Expand ⟱
Source: HalifaxProj(activate)
Type:
Macrophages are a type of white blood cell that play a crucial role in the immune system, including the response to cancer. They are derived from monocytes and can be found in various tissues throughout the body. In the context of cancer, macrophages can have both pro-tumor and anti-tumor effects, depending on their activation state and the tumor microenvironment.
In many tumors, macrophages are recruited to the tumor microenvironment and are referred to as tumor-associated macrophages (TAMs).
Protumorigenic: Macrophages, particularly when polarized to the M2 phenotype, are generally considered protumorigenic. They can secrete cytokines, growth factors, and enzymes that promote tumor cell proliferation, angiogenesis, and tissue remodeling. Additionally, they can suppress the activity of cytotoxic T cells and natural killer (NK) cells, aiding tumor immune evasion.
Antitumorigenic: Conversely, M1 macrophages (the pro-inflammatory subtype) can have antitumor effects by promoting inflammation and enhancing the immune response against tumors. They can produce pro-inflammatory cytokines and reactive oxygen species that can directly kill tumor cells.
Scientific Papers found: Click to Expand⟱
1242- BBM,    Berbamine Exerts Anti-Inflammatory Effects via Inhibition of NF-κB and MAPK Signaling Pathways
- in-vivo, Nor, NA
*Macrophages↓, *Neut↓, *p‑NF-kB↓, *p‑MAPK↓, *p‑JNK↓, *p‑ERK↓,
221- MFrot,  MF,    Low Frequency Magnetic Fields Enhance Antitumor Immune Response against Mouse H22 Hepatocellular Carcinoma
- in-vivo, Liver, NA
OS↑, TumCG↓, IL6↓, GM-CSF↓, CXCc↓, Macrophages↑, DCells↑, CD4+↑, CD8+↑, IL12↑,
871- RES,  CUR,  QC,    The effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing mice
- in-vitro, BC, 4T1 - in-vivo, BC, 4T1
T-Cell↑, Neut↓, Macrophages↓, ROS↑, MMP↓, other↓, AntiTum↑, TumVol↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 1,  

Immune & Inflammatory Signaling ⓘ

CD4+↑, 1,   CXCc↓, 1,   DCells↑, 1,   GM-CSF↓, 1,   IL12↑, 1,   IL6↓, 1,   Macrophages↓, 1,   Macrophages↑, 1,   Neut↓, 1,   T-Cell↑, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,  

Functional Outcomes ⓘ

AntiTum↑, 1,   OS↑, 1,   TumVol↓, 1,  

Infection & Microbiome ⓘ

CD8+↑, 1,  
Total Targets: 19

Pathway results for Effect on Normal Cells:


Cell Death ⓘ

p‑JNK↓, 1,   p‑MAPK↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↓, 1,  

Immune & Inflammatory Signaling ⓘ

Macrophages↓, 1,   Neut↓, 1,   p‑NF-kB↓, 1,  
Total Targets: 6

Scientific Paper Hit Count for: Macrophages, Macrophages
1 Berbamine
1 Magnetic Field Rotating
1 Magnetic Fields
1 Resveratrol
1 Curcumin
1 Quercetin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:178  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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