Database Query Results : , , MAP2K1/MEK1

MAP2K1/MEK1, mitogen-activated protein kinase kinase 1: Click to Expand ⟱
Source: CGL-Driver Genes
Type: Oncogene
MAP2K1, also known as MEK1, is a gene that encodes a protein involved in the MAPK/ERK signaling pathway, which plays a crucial role in cell proliferation, differentiation, and survival. MAP2K1 mutations are found in several types of cancer, including melanoma, lung cancer, and colorectal cancer. These mutations can lead to constitutive activation of the MAPK pathway, promoting uncontrolled cell growth and survival.
MEK inhibitors, which block the activity of MEK1 and its counterpart MEK2, are being investigated in clinical trials for various cancers, particularly those with MAPK pathway alterations.
MAP2K1 is found to be overexpressed, which can lead to enhanced activation of the MAPK/ERK signaling pathway. This overexpression is often associated with aggressive tumor behavior and poor prognosis. For example, elevated levels of MAP2K1 have been observed in certain types of melanoma and colorectal cancer.
Scientific Papers found: Click to Expand⟱
324- SNP,  CPT,    Silver Nanoparticles Potentiates Cytotoxicity and Apoptotic Potential of Camptothecin in Human Cervical Cancer Cells
- in-vitro, Cerv, HeLa
ROS↑, Casp3↑, Casp9↑, Casp6↑, GSH↓, SOD↓, GPx↓, MMP↓, P53↑, P21↑, Cyt‑c↑, BID↑, BAX↑, Bcl-2↓, Bcl-xL↓, Akt↓, Raf↓, ERK↓, MAP2K1/MEK1↓, JNK↑, p38↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GPx↓, 1,   GSH↓, 1,   ROS↑, 1,   SOD↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,   Raf↓, 1,  

Cell Death ⓘ

Akt↓, 1,   BAX↑, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,   BID↑, 1,   Casp3↑, 1,   Casp6↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   JNK↑, 1,   p38↑, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   MAP2K1/MEK1↓, 1,  
Total Targets: 21

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: MAP2K1/MEK1, mitogen-activated protein kinase kinase 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:179  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page