Database Query Results : , , Myc

Myc, v-myc avian myelocytomatosis viral oncogene homolog: Click to Expand ⟱
Source: TCGA
Type:
Myc is a family of regulator genes and proteins that play a crucial role in cell cycle progression, apoptosis, and cellular transformation.
Myc is often found to be overexpressed or dysregulated in many types of tumors. This overexpression can lead to uncontrolled cell division and growth, contributing to the development and progression of cancer.
Myc is frequently overexpressed in various cancers, including hematological malignancies (like Burkitt lymphoma) and solid tumors (such as breast, lung, and colon cancers). This overexpression can result from genetic alterations, such as chromosomal translocations, amplifications, or mutations.

MYC is use as a clinical biomarker for risk biology-aggressiveness.
Scientific Papers found: Click to Expand⟱
558- ART/DHA,    Artemisinin and Its Synthetic Derivatives as a Possible Therapy for Cancer
- Review, NA, NA
ROS↑, oncosis↑, Apoptosis↑, LysoPr↑, TumAuto↑, Wnt/(β-catenin)↑, AMP↓, NF-kB↓, Myc↓, CREBBP↓, mTOR↓, E-cadherin↑,
446- CUR,    The Influence of Curcumin on the Downregulation of MYC, Insulin and IGF-1 Receptors: A Possible Mechanism Underlying the Anti-Growth and Anti-Migration in Chemoresistant Colorectal Cancer Cells
- in-vitro, CRC, SW480
IR↓, IGF-1↓, Myc↓, TumCMig↓, TumCP↓,
1443- Deg,    Deguelin Action Involves c-Met and EGFR Signaling Pathways in Triple Negative Breast Cancer Cells
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-435 - in-vitro, BC, BT549
EGFR↓, Akt↓, p‑ERK↓, NF-kB↓, p‑STAT3↓, survivin↓, Myc↓, TumCG↓, cMET↓,
4916- DSF,  Cu,    The immunomodulatory function and antitumor effect of disulfiram: paving the way for novel cancer therapeutics
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, eff↑, Imm↑, ROS↑, NF-kB↓, chemoP↑, JNK↑, FOXO↑, Myc↑, TumCCA↑, Apoptosis↑, RadioS↑, PD-L1↑, eff↑, CSCs↓, Dose↝, Half-Life↑,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1?, PDK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
3205- EGCG,    The Role of Epigallocatechin-3-Gallate in Autophagy and Endoplasmic Reticulum Stress (ERS)-Induced Apoptosis of Human Diseas
- Review, Var, NA - Review, AD, NA
Beclin-1↑, ROS↑, Apoptosis↑, ER Stress↑, *Inflam↓, *cardioP↑, *antiOx↑, *LDL↓, *NF-kB↓, *MPO↓, *glucose↓, *ROS↓, ATG5↑, LC3B↑, MMP↑, lactateProd↓, VEGF↓, Zeb1↑, Wnt↑, IGF-1R↑, Fas↑, Bak↑, BAD↑, TP53↓, Myc↓, Casp8↓, LC3II↑, NOTCH3↓, eff↑, p‑Akt↓, PARP↑, *Cyt‑c↓, *BAX↓, *memory↑, *neuroP↑, *Ca+2?, GRP78/BiP↑, CHOP↑, ATF4↑, Casp3↑, Casp8↑, UPR↑,
2845- FIS,    Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, p38↓, *antiOx↑, *neuroP↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, DNAdam↑, MMP↓, eff↑, ROS↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, P53↑, p65↓, Myc↓, HSP70/HSPA5↓, HSP27↓, COX2↓, Wnt↓, EGFR↓, NF-kB↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycA1/CCNA1↓, P21↑, MMP2↓, MMP9↓, TumMeta↓, MMP1↓, MMP3↓, MMP7↓, MET↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↑, uPA↓, ChemoSen↑, EMT↓, Twist↓, Zeb1↓, cFos↓, cJun↓, EGF↓, angioG↓, VEGF↓, eNOS↓, *NRF2↑, HO-1↑, NRF2↓, GSTs↓, ATF4↓,
2929- LT,    Loss of BRCA1 in the cells of origin of ovarian cancer induces glycolysis: A window of opportunity for ovarian cancer chemoprevention
- in-vitro, Ovarian, NA
HK2↓, Myc↓, Glycolysis↓,
4900- Sal,    Anticancer Mechanisms of Salinomycin in Breast Cancer and Its Clinical Applications
- Review, BC, NA
CSCs↓, Apoptosis↑, TumAuto↑, necrosis↑, TumCP↓, TumCI↓, TumCMig↓, TumCG↓, TumMeta↓, eff↑, Bcl-2↓, cMyc↓, Snail↓, ALDH↓, Myc↓, AR↓, ROS↑, NF-kB↓, PTCH1↓, Smo↓, Gli1↓, GLI2↓, Wnt↓, mTOR↓, GSK‐3β↓, cycD1/CCND1↓, survivin↓, P21↑, p27↑, CHOP↑, Ca+2↑, DNAdam↑, Hif1a↓, VEGF↓, angioG↓, MMP↓, ATP↓, p‑P53↑, γH2AX↑, ChemoSen↑,
2197- SK,    Shikonin derivatives for cancer prevention and therapy
- Review, Var, NA
ROS↑, Ca+2↑, BAX↑, Bcl-2↓, MMP9↓, NF-kB↓, PKM2↓, Hif1a↓, NRF2↓, P53↑, DNMT1↓, MDR1↓, COX2↓, VEGF↓, EMT↓, MMP7↓, MMP13↓, uPA↓, RIP1↑, RIP3↑, Casp3↑, Casp7↑, Casp9↑, P21↓, DFF45↓, TRAIL↑, PTEN↑, mTOR↓, AR↓, FAK↓, Src↓, Myc↓, RadioS↑,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27↑, P21↑, ChemoSen↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 11

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   GSTs↓, 1,   HO-1↓, 1,   HO-1↑, 1,   HO-2↓, 1,   NRF2↓, 2,   ROS↑, 7,   ROS⇅, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 1,   CDC2↓, 1,   CDC25↓, 1,   EGF↓, 1,   MMP↓, 3,   MMP↑, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

ACC↑, 1,   AMP↓, 1,   AMPK↑, 2,   ATG7↑, 1,   cMyc↓, 2,   ECAR↝, 1,   GlucoseCon↓, 1,   Glycolysis↓, 2,   HK2↓, 1,   IR↓, 1,   lactateProd↓, 2,   PDK1?, 2,   PKM2↓, 1,   PPARγ↑, 1,   SIRT1↓, 1,  

Cell Death ⓘ

Akt↓, 3,   Akt↑, 1,   p‑Akt↓, 2,   Apoptosis↑, 4,   BAD↑, 2,   Bak↑, 1,   BAX↑, 2,   Bax:Bcl2↑, 1,   Bcl-2↓, 4,   Bcl-xL↓, 1,   BID↓, 1,   BIM↑, 1,   Casp3↑, 5,   Casp7↑, 1,   Casp8↓, 1,   Casp8↑, 2,   Casp9↑, 3,   Cyt‑c↑, 2,   Diablo↑, 2,   DR5↑, 1,   Fas↑, 2,   iNOS↓, 2,   JNK↑, 2,   MAPK↑, 1,   Mcl-1↓, 3,   MDM2↓, 1,   Myc↓, 10,   Myc↑, 1,   necrosis↑, 1,   NOXA↑, 1,   oncosis↑, 1,   p27↑, 2,   p38↓, 1,   p38↑, 1,   PUMA↑, 1,   RIP1↑, 1,   survivin↓, 4,   Telomerase↓, 1,   TRAIL↑, 2,  

Transcription & Epigenetics ⓘ

cJun↓, 1,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 2,   eIF2α↓, 1,   ER Stress↑, 1,   GRP78/BiP↑, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

ATG5↑, 1,   Beclin-1↑, 2,   LC3B↑, 1,   LC3II↑, 2,   TumAuto↑, 2,  

DNA Damage & Repair ⓘ

CYP1B1↑, 1,   DFF45↓, 1,   DNAdam↓, 1,   DNAdam↑, 2,   DNMT1↓, 2,   p16↑, 1,   P53↑, 4,   p‑P53↑, 1,   PARP↑, 1,   cl‑PARP↑, 2,   SIRT6↑, 1,   TP53↓, 1,   UHRF1↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 3,   CDK4↓, 2,   cycA1/CCNA1↓, 2,   cycD1/CCND1↓, 4,   cycE/CCNE↓, 1,   E2Fs↓, 1,   P21↓, 1,   P21↑, 4,   p‑RB1↓, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1,   CDK8↓, 1,   cFos↓, 1,   cMET↓, 2,   CREBBP↓, 1,   CSCs↓, 2,   EMT↓, 2,   ERK↓, 1,   p‑ERK↓, 2,   FOXO↑, 2,   Gli1↓, 1,   GSK‐3β↓, 2,   HDAC1↓, 1,   IGF-1↓, 1,   IGF-1R↑, 1,   mTOR↓, 5,   NOTCH↓, 2,   NOTCH3↓, 1,   P70S6K↓, 1,   PI3K↓, 2,   PTCH1↓, 1,   PTEN↑, 2,   Smo↓, 1,   Src↓, 1,   STAT3↓, 2,   p‑STAT3↓, 2,   TumCG↓, 2,   Wnt↓, 3,   Wnt↑, 1,   Wnt/(β-catenin)↓, 1,   Wnt/(β-catenin)↑, 1,  

Migration ⓘ

5LO↓, 1,   AP-1↓, 1,   Ca+2↑, 2,   Ca+2↝, 1,   DLC1↑, 1,   E-cadherin↑, 2,   FAK↓, 1,   p‑FAK↓, 1,   Fibronectin↓, 1,   GLI2↓, 1,   ITGA5↓, 1,   LysoPr↑, 1,   MET↓, 1,   MMP1↓, 1,   MMP13↓, 1,   MMP2↓, 3,   MMP3↓, 1,   MMP7↓, 3,   MMP9↓, 4,   N-cadherin↓, 2,   PKCδ↓, 1,   RIP3↑, 1,   Slug↓, 1,   SMAD3↓, 1,   Snail↓, 4,   TGF-β↓, 1,   TumCI↓, 2,   TumCMig↓, 3,   TumCP↓, 4,   TumMeta↓, 2,   Twist↓, 3,   uPA↓, 2,   Vim↓, 2,   Zeb1↓, 2,   Zeb1↑, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 3,   ATF4↓, 1,   ATF4↑, 1,   EGFR↓, 3,   Endoglin↑, 1,   eNOS↓, 1,   Hif1a↓, 3,   VEGF↓, 6,   VEGFR2↓, 1,  

Barriers & Transport ⓘ

NHE1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 4,   CXCL1↓, 1,   CXCR4↓, 1,   IL1↓, 1,   IL10↓, 1,   IL12↓, 1,   IL2↑, 1,   IL6↓, 1,   Imm↑, 1,   Inflam↓, 1,   JAK↓, 1,   JAK2↓, 1,   NF-kB↓, 8,   p65↓, 2,   PD-L1↓, 1,   PD-L1↑, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 2,   CDK6↓, 3,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 3,   Dose↝, 2,   Dose∅, 1,   eff↑, 7,   Half-Life↑, 1,   MDR1↓, 1,   RadioS↑, 4,   selectivity↑, 1,   TET2↑, 1,  

Clinical Biomarkers ⓘ

AR↓, 2,   EGFR↓, 3,   IL6↓, 1,   Myc↓, 10,   Myc↑, 1,   PD-L1↓, 1,   PD-L1↑, 1,   TP53↓, 1,  

Functional Outcomes ⓘ

chemoP↑, 1,  
Total Targets: 223

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   MPO↓, 1,   NRF2↑, 1,   ROS↓, 1,  

Core Metabolism/Glycolysis ⓘ

glucose↓, 1,   LDL↓, 1,  

Cell Death ⓘ

BAX↓, 1,   Cyt‑c↓, 1,  

Migration ⓘ

Ca+2?, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   memory↑, 1,   neuroP↑, 2,  
Total Targets: 15

Scientific Paper Hit Count for: Myc, v-myc avian myelocytomatosis viral oncogene homolog
1 Artemisinin
1 Curcumin
1 Deguelin
1 Disulfiram
1 Copper and Cu NanoParticlex
1 Ellagic acid
1 EGCG (Epigallocatechin Gallate)
1 Fisetin
1 Luteolin
1 salinomycin
1 Shikonin
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:210  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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