Database Query Results : , , NFE2L2

NFE2L2, nuclear factor (erythroid-derived 2)-like 2: Click to Expand ⟱
Source: CGL-Driver Genes
Type: Oncogene
A transcription factor that plays a crucial role in cellular defense mechanisms against oxidative stress and inflammation.
It regulates the expression of various antioxidant and detoxifying enzymes, helping to protect cells from damage caused by reactive oxygen species (ROS).
In many cancers, NRF2 is found to be constitutively activated due to mutations in the NFE2L2 gene or alterations in its regulatory pathways.
Scientific Papers found: Click to Expand⟱
414- CUR,    Transcriptome Investigation and In Vitro Verification of Curcumin-Induced HO-1 as a Feature of Ferroptosis in Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
Ferroptosis↑, Iron↑, ROS↑, lipid-P↑, MDA↑, GSH↓, HO-1↑, NRF2↑, GPx↓, ROS↑, Iron↑, GPx4↓, HSP70/HSPA5↑, ATFs↑, CHOP↑, MDA↑, FTL↑, FTH1↑, BACH1↑, REL↑, USF1↑, NFE2L2↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,   GPx↓, 1,   GPx4↓, 1,   GSH↓, 1,   HO-1↑, 1,   Iron↑, 2,   lipid-P↑, 1,   MDA↑, 2,   NFE2L2↑, 1,   NRF2↑, 1,   ROS↑, 2,  

Metal & Cofactor Biology ⓘ

FTH1↑, 1,   FTL↑, 1,  

Cell Death ⓘ

Ferroptosis↑, 1,  

Transcription & Epigenetics ⓘ

USF1↑, 1,  

Protein Folding & ER Stress ⓘ

ATFs↑, 1,   CHOP↑, 1,   HSP70/HSPA5↑, 1,  

Migration ⓘ

BACH1↑, 1,  

Angiogenesis & Vasculature ⓘ

REL↑, 1,  
Total Targets: 20

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: NFE2L2, nuclear factor (erythroid-derived 2)-like 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:217  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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