Database Query Results : , , NH3

NH3, ammonia: Click to Expand ⟱
Source:
Type:
Cancer cells can produce ammonia through processes like glutaminolysis, where glutamine is metabolized to support rapid growth and proliferation.
High levels of ammonia can suppress the function of certain immune cells, such as T cells and natural killer (NK) cells, potentially allowing tumors to evade immune surveillance.
Scientific Papers found: Click to Expand⟱
932- BBR,    The short-term effects of berberine in the liver: Narrow margins between benefits and toxicity
- in-vivo, Nor, NA
*glucoNG↓, *Glycolysis↑, *NH3↑, *NADPH/NADP+↑, *ATP↓, *toxicity↑,
2048- PB,    Sodium Phenylbutyrate Inhibits Tumor Growth and the Epithelial-Mesenchymal Transition of Oral Squamous Cell Carcinoma In Vitro and In Vivo
- in-vitro, OS, CAL27 - in-vitro, Oral, HSC3 - in-vitro, OS, SCC4 - in-vivo, NA, NA
*NH3↓, *HDAC↓, *ER Stress↓, Apoptosis?, Bcl-2↓, cl‑Casp3↑, TGF-β↑, N-cadherin↓, E-cadherin↑, TumVol↓, eff↑,
2029- PB,    Phenylbutyric Acid: simple structure - multiple effects
- Review, Var, NA
NH3↓, HDAC↓, ChemChap↑,
2068- PB,    Phenylbutyrate-induced glutamine depletion in humans: effect on leucine metabolism
- in-vivo, Nor, NA
glut↓, NH3↓, eff↝,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

glut↓, 1,   NH3↓, 2,  

Cell Death ⓘ

Apoptosis?, 1,   Bcl-2↓, 1,   cl‑Casp3↑, 1,  

Protein Folding & ER Stress ⓘ

ChemChap↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   N-cadherin↓, 1,   TGF-β↑, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,   eff↝, 1,  

Functional Outcomes ⓘ

TumVol↓, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

NADPH/NADP+↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,  

Core Metabolism/Glycolysis ⓘ

glucoNG↓, 1,   Glycolysis↑, 1,   NH3↓, 1,   NH3↑, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,  

Functional Outcomes ⓘ

toxicity↑, 1,  
Total Targets: 9

Scientific Paper Hit Count for: NH3, ammonia
3 Phenylbutyrate
1 Berberine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:218  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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