Database Query Results : , , NOTCH2

NOTCH2, Notch homolog 2 (Drosophila): Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
NOTCH2 is a member of the Notch signaling pathway, which plays a crucial role in cell differentiation, proliferation, and apoptosis.
NOTCH2 can act as either a tumor suppressor or an oncogene.
Notch2 expression varies widely across cancer types. In some tumors, such as certain hematological malignancies and solid tumors like breast or lung cancer, Notch2 may be overexpressed or exhibit enhanced signaling activity.

– In contrast, other studies have observed reduced expression of Notch2 in tumors like hepatocellular carcinoma or pancreatic cancer, suggesting that its role can differ based on tissue context and tumor subtype.
Scientific Papers found: Click to Expand⟱
2685- BBR,    Berberine induces neuronal differentiation through inhibition of cancer stemness and epithelial-mesenchymal transition in neuroblastoma cells
- in-vitro, neuroblastoma, NA
CSCs↓, CD133↓, β-catenin/ZEB1↓, n-MYC↓, SOX2↓, NOTCH2↓, Nestin↓, TumCCA↑, TumCP↓, CDK1↓, Cyc↓, Apoptosis↑, Bax:Bcl2↑, NCAM↓, MMP2↓, MMP9↓, *Smad1↑, *HSP70/HSPA5↑, *LAMs↑,
3098- RES,    Regulation of Cell Signaling Pathways and miRNAs by Resveratrol in Different Cancers
- Review, Var, NA
NOTCH2↓, Wnt↓, β-catenin/ZEB1↓, p‑SMAD2↓, p‑SMAD3↓, PTCH1↓, Smo↓, Gli1↓, E-cadherin↑, NOTCH⇅, TAC?, NKG2D↑, DR4↑, survivin↓, DR5↑, BAX↑, p27↑, cycD1/CCND1↓, Bcl-2↓, STAT3↓, STAT5↓, JAK↓, DNAdam↑, γH2AX↑,
3097- RES,    Resveratrol Induces Notch2-mediated Apoptosis and Suppression of Neuroendocrine Markers in Medullary Thyroid Cancer
- in-vitro, Thyroid, TT
TumCG↓, cl‑Casp3↑, p‑PARP↑, NOTCH2↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

TAC?, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   cl‑Casp3↑, 1,   DR4↑, 1,   DR5↑, 1,   p27↑, 1,   survivin↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   p‑PARP↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   Cyc↓, 1,   cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   CSCs↓, 1,   Gli1↓, 1,   n-MYC↓, 1,   Nestin↓, 1,   NOTCH⇅, 1,   NOTCH2↓, 2,   NOTCH2↑, 1,   PTCH1↓, 1,   Smo↓, 1,   SOX2↓, 1,   STAT3↓, 1,   STAT5↓, 1,   TumCG↓, 1,   Wnt↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   MMP2↓, 1,   MMP9↓, 1,   NCAM↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   TumCP↓, 1,   β-catenin/ZEB1↓, 2,  

Immune & Inflammatory Signaling ⓘ

JAK↓, 1,  

Functional Outcomes ⓘ

NKG2D↑, 1,  
Total Targets: 42

Pathway results for Effect on Normal Cells:


Protein Folding & ER Stress ⓘ

HSP70/HSPA5↑, 1,  

Migration ⓘ

LAMs↑, 1,   Smad1↑, 1,  
Total Targets: 3

Scientific Paper Hit Count for: NOTCH2, Notch homolog 2 (Drosophila)
2 Resveratrol
1 Berberine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:222  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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