Database Query Results : , , B2M

B2M, beta-2-microglobulin: Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
B2M Antigen Presentation, Immune Escape, and Biomarker Roles High B2M expression correlated with worse prognosis. Our results indicate that B2M and HLA-A loss occurs frequently in tumors.
B2M is considered a tumor suppressor gene.
Elevated serum B2M is strongly associated with poor prognosis in: Multiple myeloma, Lymphomas (CLL, NHL), and Some leukemias
Dual Nature: Tumor Suppression vs Disease Severity
Loss of B2M (tumor cell)
→ Immune escape, therapy resistance
High B2M (serum)
→ High tumor burden, inflammation, poor prognosis


β2-Microglobulin is essential for anti-tumor immune recognition.
-Loss of B2M in tumor cells enables immune escape and immunotherapy resistance.
-Elevated circulating B2M reflects tumor burden and poor prognosis, especially in hematologic malignancies.


Scientific Papers found: Click to Expand⟱
3421- TQ,    Insights into the molecular interactions of thymoquinone with histone deacetylase: evaluation of the therapeutic intervention potential against breast cancer
- Analysis, Nor, NA - in-vivo, Nor, NA - in-vitro, BC, MCF-7 - in-vitro, Nor, HaCaT
HDAC↓, P21↑, Maspin↑, BAX↑, B2M↓, TumCCA↑, selectivity↑, *toxicity↓, TumCMig↓, TumCP↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death ⓘ

BAX↑, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,  

Migration ⓘ

TumCMig↓, 1,   TumCP↓, 1,  

Immune & Inflammatory Signaling ⓘ

B2M↓, 1,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,  

Clinical Biomarkers ⓘ

B2M↓, 1,   Maspin↑, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: B2M, beta-2-microglobulin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:24  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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