Database Query Results : , , PAK1

PAK1, : Click to Expand ⟱
Source:
Type:
PAK1 (p21-activated kinase 1) is a serine/threonine kinase that plays a significant role in various cellular processes, including cell motility, proliferation, and survival.
PAK1 is often found to be overexpressed in several types of cancers, including breast cancer, prostate cancer, colorectal cancer, and pancreatic cancer.
PAK1 expression can be regulated by various oncogenic signaling pathways, including those involving RAS, PI3K/Akt, and MAPK. These pathways can lead to the activation of PAK1, further promoting cancer cell survival and proliferation.
In many cancer types, PAK1 expression and/or activity is frequently upregulated.
Overexpression and/or hyperactivation of PAK1 has been reported in breast, ovarian, colorectal, lung, and other cancers.
Scientific Papers found: Click to Expand⟱
1662- PBG,    The immunomodulatory and anticancer properties of propolis
- Review, Var, NA
IL6↓, IL12↓, IL10↑, CSCs↓, PAK1↓, VEGF↓, MMP2↓, MMP9↓, NF-kB↓, Hif1a↓, ChemoSen↑, RadioS↑,
1676- PBG,    Use of Stingless Bee Propolis and Geopropolis against Cancer—A Literature Review of Preclinical Studies
- Review, Var, NA
ROS↑, MMP↓, Bcl-2↓, eff↑, tumCV↓, TumCCA↑, angioG↓, PAK1↓, HDAC1↓, HDAC2↓, P53↑, PCNA↓, cycD1/CCND1↓, cycE/CCNE↓, P21?, BAX↑, cl‑Casp3↑, cl‑PARP↑, ChemoSen↑,
1073- SK,  Chemo,    Natural Compound Shikonin Is a Novel PAK1 Inhibitor and Enhances Efficacy of Chemotherapy against Pancreatic Cancer Cells
- in-vitro, PC, PANC1 - in-vitro, PC, Bxpc-3
PAK1↓, TumCP↓, Apoptosis↑, ChemoSen↑, ROS↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 2,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   cl‑Casp3↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,   cl‑PARP↑, 1,   PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   P21?, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CSCs↓, 1,   HDAC1↓, 1,   HDAC2↓, 1,  

Migration ⓘ

MMP2↓, 1,   MMP9↓, 1,   PAK1↓, 3,   TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   Hif1a↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL10↑, 1,   IL12↓, 1,   IL6↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 3,   eff↑, 1,   RadioS↑, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,  
Total Targets: 32

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PAK1,
2 Propolis -bee glue
1 Shikonin
1 Chemotherapy
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:240  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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