Database Query Results : , , PAX5

PAX5, paired box 5: Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
PAX5 (Paired Box 5) is a transcription factor that plays a crucial role in the development of B cells, which are a type of white blood cell involved in the immune response. It is primarily expressed in B-lineage cells and is essential for B cell differentiation and function.
PAX5 mutations can lead to the loss of function of the protein, which may result in the inability of B cells to properly differentiate. This can create an environment conducive to the development of leukemia or lymphoma.
PAX5, as a key transcription factor in B-cell development, plays a critical role in the pathogenesis of B-cell malignancies. Its alteration—commonly observed as mutations, deletions, or fusion events—can impair normal differentiation and contribute to oncogenesis. In this setting, normal PAX5 function is tumor suppressive, and its disruption generally correlates with a more aggressive disease and poorer prognosis.
Scientific Papers found: Click to Expand⟱

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 0

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PAX5, paired box 5
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:241  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page