Database Query Results : , , RET

RET, Rearranged during Transfection proto-oncogene: Click to Expand ⟱
Source: CGL-Driver Genes
Type: Oncogene
RET (Rearranged during Transfection) is a gene that encodes a receptor tyrosine kinase, which plays a crucial role in cell signaling, particularly in the development of the nervous system and the regulation of various cellular processes.
Scientific Papers found: Click to Expand⟱
3156- Ash,    Withaferin A: From ayurvedic folk medicine to preclinical anti-cancer drug
- Review, Var, NA
MAPK↑, p38↑, BAX↑, BIM↑, CHOP↑, ROS↑, DR5↑, Apoptosis↑, Ferroptosis↑, GPx4↓, BioAv↝, HSP90↓, RET↓, E6↓, E7↓, Akt↓, cMET↓, Glycolysis↓, TCA↓, NOTCH1↓, STAT3↓, AP-1↓, PI3K↓, eIF2α↓, HO-1↑, TumCCA↑, CDK1↓, *hepatoP↑, *GSH↑, *NRF2↑, Wnt↓, EMT↓, uPA↓, CSCs↓, Nanog↓, SOX2↓, CD44↓, lactateProd↓, Iron↑, NF-kB↓,
3377- QC,    Quercetin inhibits a large panel of kinases implicated in cancer cell biology
PDGF↓, FLT3↓, JAK3↓, MET↓, RET↓, FGFR2↓, other↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,   GPx4↓, 1,   HO-1↑, 1,   Iron↑, 1,   ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

Glycolysis↓, 1,   lactateProd↓, 1,   TCA↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,   BAX↑, 1,   BIM↑, 1,   DR5↑, 1,   Ferroptosis↑, 1,   MAPK↑, 1,   p38↑, 1,  

Kinase & Signal Transduction ⓘ

RET↓, 2,  

Transcription & Epigenetics ⓘ

other↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   eIF2α↓, 1,   HSP90↓, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

CD44↓, 1,   cMET↓, 1,   CSCs↓, 1,   EMT↓, 1,   FGFR2↓, 1,   FLT3↓, 1,   Nanog↓, 1,   NOTCH1↓, 1,   PI3K↓, 1,   SOX2↓, 1,   STAT3↓, 1,   Wnt↓, 1,  

Migration ⓘ

AP-1↓, 1,   MET↓, 1,   PDGF↓, 1,   uPA↓, 1,  

Immune & Inflammatory Signaling ⓘ

JAK3↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↝, 1,  

Clinical Biomarkers ⓘ

E6↓, 1,   E7↓, 1,  
Total Targets: 44

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

GSH↑, 1,   NRF2↑, 1,  

Functional Outcomes ⓘ

hepatoP↑, 1,  
Total Targets: 3

Scientific Paper Hit Count for: RET, Rearranged during Transfection proto-oncogene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:272  State#:%  Dir#:%
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