Database Query Results : , , SOCS1

SOCS1, suppressor of cytokine signaling 1: Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
SOCS1 (Suppressor of Cytokine Signaling 1) is a protein that plays a critical role in regulating the immune response and cellular signaling pathways. It is part of the SOCS family of proteins, which are known to inhibit cytokine signaling and modulate various cellular processes, including cell growth, differentiation, and apoptosis.
SOCS1 is often considered a tumor suppressor because it can inhibit pathways that promote cell proliferation and survival, such as the JAK/STAT signaling pathway. Dysregulation of this pathway is commonly observed in various cancers.
In many cancers, SOCS1 expression is found to be downregulated or silenced. This can occur through mechanisms such as promoter methylation, histone modifications, or genetic mutations. The loss of SOCS1 expression can lead to unchecked activation of signaling pathways, particularly the JAK/STAT pathway, which is associated with increased cell proliferation and survival.
Scientific Papers found: Click to Expand⟱
573- ART/DHA,    Artesunate suppresses tumor growth and induces apoptosis through the modulation of multiple oncogenic cascades in a chronic myeloid leukemia xenograft mouse model
- vitro+vivo, NA, NA
p‑p38↓, p‑ERK↓, p‑CREB↓, p‑Chk2↓, p‑STAT5↓, p‑RSK↓, SOCS1↑, Apoptosis↑, Casp3↑,
424- CUR,    Curcumin inhibits autocrine growth hormone-mediated invasion and metastasis by targeting NF-κB signaling and polyamine metabolism in breast cancer cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
Src↓, p‑STAT1↓, p‑Akt↓, p‑p44↓, p‑p42↓, RAS↓, Raf↓, Vim↓, β-catenin/ZEB1↓, P53↓, Bcl-2↓, Mcl-1↓, PIAS-3↑, SOCS-3↑, SOCS1↑, ROS↑, NF-kB↓, PAO↑, SSAT↑, P21↑, Bak↑,
3359- QC,    Quercetin modifies 5′CpG promoter methylation and reactivates various tumor suppressor genes by modulating epigenetic marks in human cervical cancer cells
- in-vitro, Cerv, HeLa
DNMTs↓, HDAC↓, HMTs↓, DNMT3A↓, EZH2↓, HDAC1↓, HDAC2↓, HDAC6↓, HDAC11↓, G9a↓, TIMP3↑, PTEN↑, SOCS1↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

PAO↑, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

p‑p42↓, 1,   Raf↓, 1,  

Core Metabolism/Glycolysis ⓘ

p‑CREB↓, 1,   SSAT↑, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   Apoptosis↑, 1,   Bak↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   p‑Chk2↓, 1,   Mcl-1↓, 1,   p‑p38↓, 1,   p‑RSK↓, 1,  

Transcription & Epigenetics ⓘ

EZH2↓, 1,  

DNA Damage & Repair ⓘ

DNMT3A↓, 1,   DNMTs↓, 1,   G9a↓, 1,   P53↓, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↓, 1,   HDAC↓, 1,   HDAC1↓, 1,   HDAC11↓, 1,   HDAC2↓, 1,   HDAC6↓, 1,   HMTs↓, 1,   PIAS-3↑, 1,   PTEN↑, 1,   RAS↓, 1,   Src↓, 1,   p‑STAT1↓, 1,   p‑STAT5↓, 1,  

Migration ⓘ

p‑p44↓, 1,   TIMP3↑, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,   SOCS-3↑, 1,   SOCS1↑, 3,  

Clinical Biomarkers ⓘ

EZH2↓, 1,  
Total Targets: 42

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: SOCS1, suppressor of cytokine signaling 1
1 Artemisinin
1 Curcumin
1 Quercetin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:288  State#:%  Dir#:%
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