Database Query Results : , , STAT

STAT, Signal transducer and activator of transcription: Click to Expand ⟱
Source: CGL-CS
Type:
STAT proteins, or Signal Transducer and Activator of Transcription proteins, are a family of transcription factors that play a crucial role in various cellular processes, including cell growth, differentiation, and apoptosis. They are activated by cytokines and growth factors and are involved in signaling pathways that can influence cancer development and progression.
STAT proteins can promote cell division and survival, leading to increased tumor growth.
Many cancers exhibit overexpression of certain STAT proteins, particularly STAT3 and STAT5.
Scientific Papers found: Click to Expand⟱
3450- ALA,    α-Lipoic Acid Inhibits Expression of IL-8 by Suppressing Activation of MAPK, Jak/Stat, and NF-κB in H. pylori-Infected Gastric Epithelial AGS Cells
- in-vitro, NA, AGS
*IL8↓, *MAPK↓, *JAK↓, *STAT↓, *NF-kB↓,
171- Api,    Apigenin in cancer therapy: anti-cancer effects and mechanisms of action
- Review, Var, NA
PI3K/Akt↓, NF-kB↓, CK2↓, FOXO↓, MAPK↝, ERK↓, p‑JAK↓, Wnt/(β-catenin)↓, ROS↑, CDC25↓, p‑STAT↓, DNAdam↑,
269- Api,    Cytotoxicity of apigenin on leukemia cell lines: implications for prevention and therapy
- in-vitro, AML, HL-60 - in-vitro, AML, K562 - in-vitro, AML, TF1
JAK↓, PI3K↓, cDC2↓, STAT↓,
565- ART/DHA,    Artesunate as an Anti-Cancer Agent Targets Stat-3 and Favorably Suppresses Hepatocellular Carcinoma
STAT↓, IL6↓, pro‑Casp3↝, Bcl-xL↝, survivin↝,
2818- CUR,    Novel Insight to Neuroprotective Potential of Curcumin: A Mechanistic Review of Possible Involvement of Mitochondrial Biogenesis and PI3/Akt/ GSK3 or PI3/Akt/CREB/BDNF Signaling Pathways
- Review, AD, NA
*neuroP↑, *ROS↓, *Inflam↓, *Apoptosis↓, *cognitive↑, *cardioP↑, other↑, *COX2↓, *IL1β↓, *TNF-α↓, NF-kB↓, *PGE2↓, *iNOS↓, *NO↓, *IL2↓, *IL4↓, *IL6↓, *INF-γ↓, *GSK‐3β↓, *STAT↓, *GSH↑, *MDA↓, *lipid-P↓, *SOD↑, *GPx↑, *Catalase↑, *GSR↓, *LDH↓, *H2O2↓, *Casp3↓, *Casp9↓, *NRF2↑, *AIF↓, *ATP↑,
4709- CUR,    Curcumin Regulates Cancer Progression: Focus on ncRNAs and Molecular Signaling Pathways
- Review, Var, NA
miR-21↓, TumCP↓, TumCMig↓, TumCI↓, Apoptosis↑, miR-99↑, JAK↓, STAT↓, cycD1/CCND1↓, P21↑, ChemoSen↑, miR-192-5p↑, cMyc↓, Wnt↓, β-catenin/ZEB1↓, miR-130a↓,
464- CUR,    Curcumin inhibits the viability, migration and invasion of papillary thyroid cancer cells by regulating the miR-301a-3p/STAT3 axis
- in-vitro, Thyroid, BCPAP - in-vitro, Thyroid, TPC-1
TumCI↓, TumCI↓, MMP2↓, MMP9↓, EMT↓, STAT3↓, miR-301a-3p↓, STAT↓, N-cadherin↓, Vim↓, Fibronectin↓, p‑JAK↓, p‑JAK2↓, p‑JAK3↓, p‑STAT1↓, p‑STAT2↓, E-cadherin↑,
651- EGCG,    Epigallocatechin-3-Gallate Therapeutic Potential in Cancer: Mechanism of Action and Clinical Implications
ROS↑, p‑AMPK↑, mTOR↓, FAK↓, Smo↓, Gli1↓, HH↓, TumCMig↓, TumCI↓, NOTCH↓, JAK↓, STAT↓, Bcl-2↓, Bcl-xL↓, BAX↑, Casp9↑,
834- Gra,    Anticancer Properties of Graviola (Annona muricata): A Comprehensive Mechanistic Review
- Review, NA, NA
EGFR↓, PI3K/Akt↓, NF-kB↓, JAK↓, STAT↓, Hif1a↓, GLUT1↓, GLUT4↓, ROS↑, Catalase↑, SOD↑, HO-1↑,
3847- MSM,    Methylsulfonylmethane: Applications and Safety of a Novel Dietary Supplement
- Review, Arthritis, NA
*Inflam↓, *Pain↓, *ROS↓, *antiOx↑, *Dose↝, *Half-Life↝, *NF-kB↓, *IL1↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2↓, *NLRP3↓, *NRF2↑, *STAT↓, *Cartilage↑, *eff↑, *eff↑, *GSH↑, *uricA↓, tumCV↓, TumCCA↑, necrosis↑, Apoptosis↑, VEGF↓, HSP90↓, IGF-1?,
1803- NarG,    Naringin and naringenin as anticancer agents and adjuvants in cancer combination therapy: Efficacy and molecular mechanisms of action, a comprehensive narrative review
- Review, Var, NA
JAK↓, STAT↓, PI3K↓, Akt↓, mTOR↓, NF-kB↓, COX2↓, NOTCH↓, TumCCA↑,
4972- Nimb,    Chemopreventive and therapeutic effects of nimbolide in cancer: The underlying mechanisms
- Review, Var, NA
Apoptosis↑, TumCP↓, NF-kB↓, Wnt↓, PI3K↓, MAPK↓, JAK↓, STAT↓,
1989- Part,    Parthenolide and Its Soluble Analogues: Multitasking Compounds with Antitumor Properties
- Review, Var, NA
eff↑, NF-kB↓, STAT↓, ROS↑, Inflam↓, Wnt↓, TCF-4↓, LEF1↓, GSH↓, MMP↓, Casp↑, eff↓, CSCs↓,
3259- PBG,    Propolis and its therapeutic effects on renal diseases: A review
- Review, Nor, NA
*Inflam↓, *COX2↓, *ROS↓, *NO↓, *NF-kB↓, TumCP↓, angioG↓, VEGF↓, STAT↓, Hif1a↓, RenoP↑, TLR4↓, *MDA↓, *GSH↑, *SOD↑, *Catalase↑, *toxicity∅,
3380- QC,    Quercetin as a JAK–STAT inhibitor: a potential role in solid tumors and neurodegenerative diseases
- Review, Var, NA - Review, Park, NA - Review, AD, NA
JAK↓, STAT↓, Inflam↓, NO↓, COX2↓, CRP↓, selectivity↑, *neuroP↑, STAT3↓, cycD1/CCND1↓, MMP2↓, STAT4↓, JAK2↓, TumCP↓, Diff↓, *eff↑, *IL6↓, *TNF-α↓, *IL1β↓, *Aβ↓,
4787- QC,    Quercetin: A Phytochemical with Pro-Apoptotic Effects in Colon Cancer Cells
- Review, CRC, NA
Inflam↓, AntiCan↑, Apoptosis↑, MMP↓, P53↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, NF-kB↓, IL6↓, IL1β↓, *antiOx↑, *lipid-P↓, *ROS↓, MAPK↓, JAK↓, STAT↓, PI3K↓, Akt↓, chemoP↑, ROS⇅, DNAdam↑, ChemoSen↝,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 16

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   GSH↓, 1,   HO-1↑, 1,   ROS↑, 4,   ROS⇅, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics ⓘ

CDC25↓, 1,   MMP↓, 2,  

Core Metabolism/Glycolysis ⓘ

p‑AMPK↑, 1,   cMyc↓, 1,   PI3K/Akt↓, 2,  

Cell Death ⓘ

Akt↓, 2,   Apoptosis↑, 4,   BAX↑, 2,   Bcl-2↓, 2,   Bcl-xL↓, 1,   Bcl-xL↝, 1,   Casp↑, 1,   Casp3↑, 1,   pro‑Casp3↝, 1,   Casp9↑, 2,   CK2↓, 1,   MAPK↓, 2,   MAPK↝, 1,   necrosis↑, 1,   survivin↝, 1,  

Transcription & Epigenetics ⓘ

miR-192-5p↑, 1,   miR-21↓, 1,   other↑, 1,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

HSP90↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   P53↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 2,   P21↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

cDC2↓, 1,   CSCs↓, 1,   Diff↓, 1,   EMT↓, 1,   ERK↓, 1,   FOXO↓, 1,   Gli1↓, 1,   HH↓, 1,   IGF-1?, 1,   miR-99↑, 1,   mTOR↓, 2,   NOTCH↓, 2,   PI3K↓, 4,   Smo↓, 1,   STAT↓, 12,   p‑STAT↓, 1,   p‑STAT1↓, 1,   p‑STAT2↓, 1,   STAT3↓, 2,   STAT4↓, 1,   TCF-4↓, 1,   Wnt↓, 3,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

E-cadherin↑, 1,   FAK↓, 1,   Fibronectin↓, 1,   LEF1↓, 1,   miR-130a↓, 1,   miR-301a-3p↓, 1,   MMP2↓, 2,   MMP9↓, 1,   N-cadherin↓, 1,   TumCI↓, 4,   TumCMig↓, 2,   TumCP↓, 4,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   EGFR↓, 1,   Hif1a↓, 2,   NO↓, 1,   VEGF↓, 2,  

Barriers & Transport ⓘ

GLUT1↓, 1,   GLUT4↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   CRP↓, 1,   IL1β↓, 1,   IL6↓, 2,   Inflam↓, 3,   JAK↓, 8,   p‑JAK↓, 2,   JAK2↓, 1,   p‑JAK2↓, 1,   p‑JAK3↓, 1,   NF-kB↓, 7,   TLR4↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   ChemoSen↝, 1,   eff↓, 1,   eff↑, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

CRP↓, 1,   EGFR↓, 1,   IL6↓, 2,  

Functional Outcomes ⓘ

AntiCan↑, 1,   chemoP↑, 1,   RenoP↑, 1,  
Total Targets: 103

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   Catalase↑, 2,   GPx↑, 1,   GSH↑, 3,   GSR↓, 1,   H2O2↓, 1,   lipid-P↓, 2,   MDA↓, 2,   NRF2↑, 2,   ROS↓, 4,   SOD↑, 2,   uricA↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↓, 1,   ATP↑, 1,  

Core Metabolism/Glycolysis ⓘ

LDH↓, 1,  

Cell Death ⓘ

Apoptosis↓, 1,   Casp3↓, 1,   Casp9↓, 1,   iNOS↓, 2,   MAPK↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

GSK‐3β↓, 1,   STAT↓, 3,  

Migration ⓘ

Cartilage↑, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 2,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 3,   IL1↓, 1,   IL1β↓, 2,   IL2↓, 1,   IL4↓, 1,   IL6↓, 3,   IL8↓, 1,   INF-γ↓, 1,   Inflam↓, 3,   JAK↓, 1,   NF-kB↓, 3,   PGE2↓, 1,   TNF-α↓, 3,  

Protein Aggregation ⓘ

Aβ↓, 1,   NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↑, 3,   Half-Life↝, 1,  

Clinical Biomarkers ⓘ

IL6↓, 3,   LDH↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,   cognitive↑, 1,   neuroP↑, 2,   Pain↓, 1,   toxicity∅, 1,  
Total Targets: 49

Scientific Paper Hit Count for: STAT, Signal transducer and activator of transcription
3 Curcumin
2 Apigenin (mainly Parsley)
2 Quercetin
1 Alpha-Lipoic-Acid
1 Artemisinin
1 EGCG (Epigallocatechin Gallate)
1 Graviola
1 Methylsulfonylmethane
1 Naringin
1 Nimbolide
1 Parthenolide
1 Propolis -bee glue
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:294  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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