Database Query Results : , , PDGF

PDGF, Platelet-derived growth factors: Click to Expand ⟱
Source:
Type:
Activation of the PDGF/PDGFR signaling pathway is associated with cancer proliferation, metastasis, invasion, and angiogenesis.

Many tumor types exhibit increased PDGF ligand and/or receptor expression, leading to autocrine or paracrine stimulation of cancer cells as well as the surrounding stromal cells.
– High PDGF signaling is noted in gliomas, sarcomas, breast cancer, and other solid tumors, where it contributes to tumor growth and angiogenesis.
Scientific Papers found: Click to Expand⟱
958- Api,    Apigenin suppresses tumor angiogenesis and growth via inhibiting HIF-1α expression in non-small cell lung carcinoma
- in-vitro, Lung, NCIH1299
Hif1a↓, VEGF↓, VEGFR2↓, PDGF↓, angioG↓,
3174- Ash,    Withaferin A Acts as a Novel Regulator of Liver X Receptor-α in HCC
- in-vitro, HCC, HepG2 - in-vitro, HCC, Hep3B - in-vitro, HCC, HUH7
NF-kB↓, angioG↓, Inflam↓, TumCP↓, TumCMig↓, TumCI↓, Sp1/3/4↓, VEGF↓, angioG↓, uPA↓, PDGF↓, MCP1↓, ICAM-1↓, *NRF2↑, *hepatoP↑,
2713- BBR,    Berberine improved the microbiota in lung tissue of colon cancer and reversed the bronchial epithelial cell changes caused by cancer cells
- in-vitro, Nor, BEAS-2B
*GutMicro↑, *IL6↑, *IL10↑, *IL17↑, *IFN-γ↑, PDGF↓, *RAD51↓,
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2↓, MMP9↓, CXCR4↓, VEGF↓, eff↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, eff↑, MMP1↓, MMP2↓, eff↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑,
2788- CHr,    Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action
- Review, Var, NA
*neuroP↑, *Inflam↓, *ROS↓, NF-kB↓, *PCNA↓, *COX2↓, ChemoSen↑, Hif1a↓, angioG↓, *chemoPv↑, PDGF↓, *memory↑, *RenoP↑, *PPARα↑, *lipidLev↓, *hepatoP↑, *cardioP⇅, *BioAv↓,
13- CUR,    Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action
- Review, BC, NA
P53↑, DR5↑, JNK↑, NRF2↑, PPARγ↑, HER2/EBBR2↓, IR↓, ER(estro)↓, Fas↑, PDGF↓, TGF-β↓, FGF↓, EGFR↓, JAK↓, PAK↓, MAPK↓, ATPase↓, COX2↓, MMPs↓, IL1↓, IL2↓, IL5↓, IL6↓, IL8↓, IL12↓, IL18↓, NF-kB↓, NOTCH1↓, STAT1↓, STAT4↓, STAT5↓, STAT3↓,
162- CUR,  EGCG,  SFN,    Shattering the underpinnings of neoplastic architecture in LNCap: synergistic potential of nutraceuticals in dampening PDGFR/EGFR signaling and cellular proliferation
- in-vitro, Pca, LNCaP
p‑PDGF↓,
3238- EGCG,    Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications
- Review, Var, NA
Telomerase↓, DNMTs↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, HATs↓, HDAC↓, selectivity↑, uPA↓, NF-kB↓, TNF-α↓, *ROS↓, *antiOx↑, Hif1a↓, VEGF↓, MMP2↓, MMP9↓, FAK↓, TIMP2↑, Mcl-1↓, survivin↓, XIAP↓, PCNA↓, p16↑, P21↑, p27↑, pRB↑, P53↑, MDM2↑, ROS↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Diablo↑, BAX⇅, cl‑PPARα↓, PDGF↓, EGFR↓, FOXO↑, AP-1↓, JNK↓, COX2↓, angioG↓,
1656- FA,    Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling
- Review, Var, NA
tyrosinase↓, CK2↓, TumCP↓, TumCMig↓, FGF↓, FGFR1↓, PI3K↓, Akt↓, VEGF↓, FGFR1↓, FGFR2↓, PDGF↓, ALAT↓, AST↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, BAX↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, Casp3↑, Casp9↑, TIMP1↑, lipid-P↑, mtDam↑, EMT↓, Vim↓, E-cadherin↓, p‑STAT3↓, COX2↓, CDC25↓, RadioS↑, ROS↑, DNAdam↑, γH2AX↑, PTEN↑, LC3II↓, Beclin-1↓, SOD↓, Catalase↓, GPx↓, Fas↑, *BioAv↓, cMyc↓, Beclin-1↑, LC3‑Ⅱ/LC3‑Ⅰ↓,
2998- GEN,    Cellular and Molecular Mechanisms Modulated by Genistein in Cancer
- Review, Var, NA
Hif1a↓, VEGF↓, PDGF↓, uPA↓, MMP2↓, MMP9↓, chemoPv↑, TumCI↓, TumMeta↓, NF-kB↓, AP-1↓, IKKα↓, PI3K↓, Akt↓, EMT↓, CSCs↓,
4338- LT,    Luteolin: a natural product with multiple mechanisms for atherosclerosis
- Review, NA, NA
*Inflam↓, *ROS↓, *PDGF↓, *lipid-P↓, *AMPK↑, *SIRT1↑, *AntiAg↑,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
4791- Lyco,    Investigating into anti-cancer potential of lycopene: Molecular targets
- Review, Var, NA
*antiOx↑, TumCP↓, TumCCA↓, Apoptosis↑, TumCI↓, angioG↓, TumMeta↓, *Risk↓, cycD1/CCND1↓, CycD3↓, cycE/CCNE↓, CDK2↓, CDK4↓, Bcl-2↓, P21↑, p27↑, P53↑, BAX↑, selectivity↑, MMP↓, Cyt‑c↑, Wnt↓, eff↑, PPARγ↑, LDL↓, Akt↓, PI3K↓, mTOR↓, PDGF↓, NF-kB↓, eff↑,
3480- MF,    Cellular and Molecular Effects of Magnetic Fields
- Review, NA, NA
ROS↑, *Ca+2↑, *Inflam↓, *Akt↓, *mTOR↓, selectivity↑, *memory↑, *MMPs↑, *VEGF↑, *FGF↑, *PDGF↑, *TNF-α↑, *HGF/c-Met↑, *IL1↑,
3377- QC,    Quercetin inhibits a large panel of kinases implicated in cancer cell biology
PDGF↓, FLT3↓, JAK3↓, MET↓, RET↓, FGFR2↓, other↓,
3369- QC,    Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects
- Review, Pca, NA
FAK↓, TumCCA↑, p‑pRB↓, CDK2↑, CycB/CCNB1↓, CDK1↓, EMT↓, PI3K↓, MAPK↓, Wnt↓, ROS↑, miR-21↑, Akt↓, NF-kB↓, FasL↑, Bak↑, BAX↑, Bcl-2↓, Casp3↓, Casp9↑, P53↑, p38↑, MAPK↑, Cyt‑c↑, PARP↓, CHOP↑, ROS↓, LDH↑, GRP78/BiP↑, ERK↑, MDA↓, SOD↑, GSH↑, NRF2↑, VEGF↓, PDGF↓, EGF↓, FGF↓, TNF-α↓, TGF-β↓, VEGFR2↓, EGFR↓, FGFR1↓, mTOR↓, cMyc↓, MMPs↓, LC3B-II↑, Beclin-1↑, IL1β↓, CRP↓, IL10↓, COX2↓, IL6↓, TLR4↓, Shh↓, HER2/EBBR2↓, NOTCH↓, DR5↑, HSP70/HSPA5↓, CSCs↓, angioG↓, MMP2↓, MMP9↓, IGFBP3↑, uPA↓, uPAR↓, RAS↓, Raf↓, TSP-1↑,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, NA, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27↑, COX2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 17

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

chemoPv↑, 2,  

Redox & Oxidative Stress ⓘ

antiOx⇅, 1,   Catalase↓, 1,   CYP1A1↓, 1,   GPx↓, 1,   GSH↑, 1,   lipid-P?, 1,   lipid-P↑, 1,   MDA↓, 1,   NRF2↑, 2,   ROS↓, 2,   ROS↑, 5,   SOD↓, 1,   SOD↑, 1,  

Metal & Cofactor Biology ⓘ

Tf↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   CDC25↓, 1,   EGF↓, 1,   FGFR1↓, 3,   MMP↓, 2,   mtDam↑, 1,   Raf↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis ⓘ

ALAT↓, 1,   cMyc↓, 2,   FASN↓, 1,   IR↓, 1,   LDH↑, 1,   LDL↓, 1,   PPARα↓, 1,   cl‑PPARα↓, 1,   PPARγ↑, 2,   SIRT1↓, 1,   SREBP1↓, 1,  

Cell Death ⓘ

Akt↓, 5,   Apoptosis↑, 2,   Bak↑, 1,   BAX↓, 1,   BAX↑, 3,   BAX⇅, 1,   Bcl-2↓, 3,   Bcl-xL↓, 1,   Casp↑, 2,   Casp3↓, 1,   Casp3↑, 3,   Casp8↑, 2,   Casp9↑, 3,   CK2↓, 1,   Cyt‑c↑, 4,   Diablo↑, 1,   DR4↑, 1,   DR5↑, 4,   Fas↑, 3,   FasL↑, 1,   JNK↓, 1,   JNK↑, 2,   MAPK↓, 3,   MAPK↑, 1,   Mcl-1↓, 1,   MDM2↑, 1,   NOXA↑, 1,   p27↑, 4,   p38↑, 1,   PUMA↑, 1,   survivin↓, 1,   Telomerase↓, 2,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 2,   PAK↓, 1,   RET↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

HATs↓, 1,   HATs↑, 1,   miR-21↑, 1,   other↓, 1,   pRB↑, 1,   p‑pRB↓, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↓, 1,   Beclin-1↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3B-II↑, 1,   LC3II↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   DNMTs↓, 1,   p16↑, 1,   P53↑, 6,   PARP↓, 1,   PARP↑, 1,   cl‑PARP↑, 1,   PCNA↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK2↓, 5,   CDK2↑, 1,   CDK4↓, 5,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 3,   CycD3↓, 1,   cycE/CCNE↓, 3,   P21↑, 4,   p‑RB1↓, 1,   TumCCA↓, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State ⓘ

CD44↓, 1,   CSCs↓, 2,   EMT↓, 4,   ERK↓, 2,   ERK↑, 1,   p‑ERK↓, 1,   FGF↓, 3,   FGFR2↓, 2,   FLT3↓, 1,   FOXO↑, 1,   HDAC↓, 2,   IGF-1↓, 1,   IGFBP3↑, 2,   Let-7↑, 1,   mTOR↓, 2,   NOTCH↓, 2,   NOTCH1↓, 1,   PI3K↓, 5,   PTEN↑, 1,   RAS↓, 1,   Shh↓, 1,   STAT1↓, 1,   STAT3↓, 3,   p‑STAT3↓, 1,   STAT4↓, 1,   STAT5↓, 1,   TOP1↓, 2,   TOP2↓, 1,   TOP2↑, 1,   TumCG↓, 1,   tyrosinase↓, 1,   Wnt↓, 4,  

Migration ⓘ

AP-1↓, 2,   ATPase↓, 1,   CA↓, 1,   Ca+2↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   FAK↓, 4,   MET↓, 1,   miR-200b↑, 1,   miR-203↑, 1,   MMP1↓, 2,   MMP2↓, 6,   MMP9↓, 7,   MMPs↓, 2,   PDGF↓, 14,   p‑PDGF↓, 1,   PKCδ↓, 1,   TGF-β↓, 3,   TIMP1↑, 1,   TIMP2↑, 1,   TSP-1↑, 1,   TumCI↓, 4,   TumCMig↓, 3,   TumCP↓, 4,   TumMeta↓, 3,   Twist↓, 1,   uPA↓, 5,   uPAR↓, 1,   Vim↓, 2,   Zeb1↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 10,   EGFR↓, 5,   Hif1a↓, 6,   p‑PDGFR-BB↓, 1,   VEGF↓, 11,   VEGFR2↓, 3,  

Barriers & Transport ⓘ

NHE1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 6,   CRP↓, 1,   CXCR4↓, 1,   ICAM-1↓, 1,   IKKα↓, 2,   IL1↓, 2,   IL10↓, 1,   IL12↓, 1,   IL18↓, 1,   IL1α↓, 1,   IL1β↓, 1,   IL2↓, 1,   IL5↓, 1,   IL6↓, 2,   IL8↓, 1,   Inflam↓, 1,   JAK↓, 1,   JAK3↓, 1,   MCP1↓, 2,   MIP2↓, 1,   NF-kB↓, 11,   PD-L1↓, 1,   PGE2↓, 1,   PSA↓, 1,   TLR4↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission ⓘ

5HT↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 2,   CDK6↓, 2,   ER(estro)↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 4,   BioAv↑, 2,   ChemoSen↑, 2,   CYP1A2↓, 1,   Dose↑, 1,   Dose↝, 2,   eff↑, 6,   eff↝, 1,   Half-Life↓, 2,   Half-Life↝, 1,   P450↓, 1,   RadioS↑, 1,   selectivity↑, 4,  

Clinical Biomarkers ⓘ

ALAT↓, 1,   AR↓, 2,   ascitic↓, 1,   AST↓, 1,   CRP↓, 1,   EGFR↓, 5,   HER2/EBBR2↓, 2,   IL6↓, 2,   LDH↑, 1,   PD-L1↓, 1,   PSA↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 3,   cardioP↑, 1,   chemoP↑, 2,   hepatoP↑, 1,   toxicity↓, 1,   toxicity↝, 1,   toxicity∅, 1,  
Total Targets: 236

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

chemoPv↑, 1,  

Redox & Oxidative Stress ⓘ

antiOx↑, 3,   Catalase↑, 1,   GSR↑, 1,   GSTA1↑, 1,   lipid-P↓, 1,   NRF2↑, 1,   ROS↓, 4,   SOD↑, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   lipidLev↓, 1,   PPARα↑, 1,   SIRT1↑, 2,  

Cell Death ⓘ

Akt↓, 1,   HGF/c-Met↑, 1,   MAPK↑, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,  

DNA Damage & Repair ⓘ

PCNA↓, 1,   RAD51↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

FGF↑, 1,   mTOR↓, 1,  

Migration ⓘ

AntiAg↑, 1,   Ca+2↑, 1,   Ca+2↝, 1,   MMPs↑, 1,   PDGF↓, 1,   PDGF↑, 1,   TIMP1↓, 1,  

Angiogenesis & Vasculature ⓘ

VEGF↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   IFN-γ↑, 1,   IL1↑, 1,   IL10↑, 1,   IL17↑, 1,   IL6↑, 1,   IL8↓, 1,   Inflam↓, 6,   NF-kB↓, 1,   TNF-α↓, 1,   TNF-α↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,  

Clinical Biomarkers ⓘ

GutMicro↑, 1,   IL6↑, 1,  

Functional Outcomes ⓘ

cardioP⇅, 1,   hepatoP↑, 2,   memory↑, 2,   neuroP↑, 1,   RenoP↑, 1,   Risk↓, 1,  
Total Targets: 49

Scientific Paper Hit Count for: PDGF, Platelet-derived growth factors
2 Curcumin
2 EGCG (Epigallocatechin Gallate)
2 Luteolin
2 Quercetin
1 Apigenin (mainly Parsley)
1 Ashwagandha(Withaferin A)
1 Berberine
1 Boswellia (frankincense)
1 Chrysin
1 Sulforaphane (mainly Broccoli)
1 Ferulic acid
1 Genistein (soy isoflavone)
1 Lycopene
1 Magnetic Fields
1 Silymarin (Milk Thistle) silibinin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:361  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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