Database Query Results : , , Cyc

Cyc, Cyclin: Click to Expand ⟱
Source:
Type:
Cyclins are indispensable elements of the cell cycle and derangement of their function can lead to cancer formation.
Scientific Papers found: Click to Expand⟱
259- ALA,    Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells
- in-vitro, Liver, HepG2 - in-vitro, Liver, FaO
Cyc↓, P21↑, ROS↑, p‑P53↑, BAX↑, Cyt‑c↑, Casp↑, survivin↓, JNK↑, Akt↓,
581- Api,  Cisplatin,    The natural flavonoid apigenin sensitizes human CD44+ prostate cancer stem cells to cisplatin therapy
- in-vitro, Pca, CD44+
Bcl-2↓, survivin↓, Casp8↑, P53↑, Sharpin↓, APAF1↑, p‑Akt↓, NF-kB↓, P21↑, Cyc↓, CDK2↓, CDK4/6↓, Snail↓, ChemoSen↑,
177- Api,    Inhibition of MDA-MB-231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation-mediated p21WAF1/CIP1 expression
- in-vitro, BC, MDA-MB-231
Cyc↓, CycB/CCNB1↓, CDK1↓, P21↑, PCNA↝, HDAC↓,
2296- Ba,    The most recent progress of baicalein in its anti-neoplastic effects and mechanisms
- Review, Var, NA
CDK1↓, Cyc↓, p27↑, P21↑, P53↑, TumCCA↑, TumCI↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Vim↓, LC3A↑, p62↓, p‑mTOR↓, PD-L1↓, CAFs/TAFs↓, VEGF↓, ROCK1↓, Bcl-2↓, Bcl-xL↓, BAX↑, ROS↑, cl‑PARP↑, Casp3↑, Casp9↑, PTEN↑, MMP↓, Cyt‑c↑, Ca+2↑, PERK↑, IRE1↑, CHOP↑, Copper↑, Snail↓, Vim↓, Twist↓, GSH↓, NRF2↓, HO-1↓, GPx4↓, XIAP↓, survivin↓, DR5↑,
2685- BBR,    Berberine induces neuronal differentiation through inhibition of cancer stemness and epithelial-mesenchymal transition in neuroblastoma cells
- in-vitro, neuroblastoma, NA
CSCs↓, CD133↓, β-catenin/ZEB1↓, n-MYC↓, SOX2↓, NOTCH2↓, Nestin↓, TumCCA↑, TumCP↓, CDK1↓, Cyc↓, Apoptosis↑, Bax:Bcl2↑, NCAM↓, MMP2↓, MMP9↓, *Smad1↑, *HSP70/HSPA5↑, *LAMs↑,
2737- BetA,    Multiple molecular targets in breast cancer therapy by betulinic acid
- Review, Var, NA
TumCP↓, Cyc↓, TOP1↓, TumCCA↑, angioG↓, NF-kB↓, Sp1/3/4↓, VEGF↓, MMPs↓, ChemoSen↑, eff↑, MMP↓, ROS↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, lipid-P↑, RadioS↑, eff↑,
726- Bor,    Redox Mechanisms Underlying the Cytostatic Effects of Boric Acid on Cancer Cells—An Issue Still Open
- Review, NA, NA
NAD↝, SAM-e↝, PSA↓, IGF-1↓, Cyc↓, P21↓, p‑MEK↓, p‑ERK↓, ROS↑, SOD↓, Catalase↓, MDA↑, GSH↓, IL1↓, IL6↓, TNF-α↓, BRAF↝, MAPK↝, PTEN↝, PI3K/Akt↝, eIF2α↑, ATF4↑, ATF6↑, NRF2↑, BAX↑, BID↑, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓,
709- Bor,    Cellular changes in boric acid-treated DU-145 prostate cancer cells
- in-vitro, Pca, DU145
Cyc↓, MAPK↓, TumCMig↓, LAMP2↓, p‑ERK⇅, TumCM/A↑,
696- Bor,    Nothing Boring About Boron
- Review, Var, NA
*hs-CRP↓, *TNF-α↓, *SOD↑, *Catalase↑, *GPx↑, *cognitive↑, *memory↑, *Risk↓, *SAM-e↑, *NAD↝, *ATP↝, *Ca+2↝, HDAC↓, TumVol↓, IGF-1↓, PSA↓, Cyc↓, TumCMig↓, *serineP↓, HIF-1↓, *ChemoSideEff↓, *VitD↑, *Mag↑, *eff↑, Risk↓, *Inflam↓, *neuroP↑, *Calcium↑, *BMD↑, *chemoP↑, AntiCan↑, *Dose↑, *Dose↝, *BMPs↑, *testos↑, angioG↓, Apoptosis↑, *selectivity↑, *chemoPv↑,
15- CUR,  UA,    Effects of curcumin and ursolic acid in prostate cancer: A systematic review
NF-kB↝, Akt↝, AR↝, Apoptosis↝, Bcl-2↝, Casp3↝, BAX↝, P21↝, ROS↝, Apoptosis↝, Bcl-xL↝, JNK↝, MMP2↝, P53↝, PSA↝, VEGF↝, COX2↝, cycD1/CCND1↝, EGFR↝, IL6↝, β-catenin/ZEB1↝, mTOR↝, NRF2↝, p‑Akt↝, AP-1↝, Cyt‑c↝, PI3K↝, PTEN↝, Cyc↝, TNF-α↝,
843- Gra,    Graviola (Annona muricata) Exerts Anti-Proliferative, Anti-Clonogenic and Pro-Apoptotic Effects in Human Non-Melanoma Skin Cancer UW-BCC1 and A431 Cells In Vitro: Involvement of Hedgehog Signaling
- in-vitro, NMSC, A431 - in-vitro, NMSC, UW-BCC1 - in-vitro, Nor, NHEKn
TumCG↓, TumCCA↑, Cyc↓, Apoptosis↑, cl‑Casp3↑, cl‑Casp8↑, cl‑PARP↑, HH↓, Smo↓, Gli1↓, GLI2↓, Shh↓, Sufu↑, BAX↑, Bcl-2↓, *toxicity↓,
1638- HCAs,    Anticancer potential of hydroxycinnamic acids: mechanisms, bioavailability, and therapeutic applications
- Review, Nor, NA
*BioAv↓, Inflam↓, COX2↓, TumCCA↑, ChemoSen↑, RadioS↑, selectivity↑, ROS↑, DNAdam↑, antiOx↑, SOD↑, Catalase↑, GPx↑, GSH↑, NRF2↑, NF-kB↓, Cyc↓, CDK1↑, P21↑, p27↑, P53↑, VEGF↓, MAPK↓,
2545- M-Blu,    Reversing the Warburg Effect as a Treatment for Glioblastoma
- in-vitro, GBM, U87MG - NA, AD, NA - in-vitro, GBM, A172 - in-vitro, GBM, T98G
Warburg↓, OCR↑, lactateProd↓, TumCP↓, TumCCA↑, AMPK↑, ACC↓, Cyc↓, neuroP↑, Cyt‑c↝, Glycolysis↓, ECAR↓, TumCG↓, other↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 13

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↓, 1,   Catalase↑, 1,   Copper↑, 1,   GPx↑, 1,   GPx4↓, 1,   GSH↓, 2,   GSH↑, 1,   HO-1↓, 1,   lipid-P↑, 1,   MDA↑, 1,   NRF2↓, 1,   NRF2↑, 2,   NRF2↝, 1,   ROS↑, 5,   ROS↝, 1,   SAM-e↝, 1,   SOD↓, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics ⓘ

p‑MEK↓, 1,   MMP↓, 2,   OCR↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACC↓, 1,   AMPK↑, 1,   ECAR↓, 1,   Glycolysis↓, 1,   lactateProd↓, 1,   NAD↝, 1,   PI3K/Akt↝, 1,   TumCM/A↑, 1,   Warburg↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Akt↝, 1,   p‑Akt↓, 1,   p‑Akt↝, 1,   APAF1↑, 1,   Apoptosis↑, 3,   Apoptosis↝, 2,   BAX↑, 4,   BAX↝, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 5,   Bcl-2↝, 1,   Bcl-xL↓, 3,   Bcl-xL↝, 1,   BID↑, 1,   Casp↑, 1,   Casp3↑, 2,   Casp3↝, 1,   cl‑Casp3↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↑, 2,   Cyt‑c↑, 2,   Cyt‑c↝, 2,   DR5↑, 1,   JNK↑, 1,   JNK↝, 1,   MAPK↓, 2,   MAPK↝, 1,   Mcl-1↓, 1,   p27↑, 2,   survivin↓, 3,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

other↓, 1,  

Protein Folding & ER Stress ⓘ

ATF6↑, 1,   CHOP↑, 1,   eIF2α↑, 1,   IRE1↑, 1,   PERK↑, 1,  

Autophagy & Lysosomes ⓘ

LAMP2↓, 1,   LC3A↑, 1,   p62↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   P53↑, 3,   P53↝, 1,   p‑P53↑, 1,   cl‑PARP↑, 2,   PCNA↝, 1,  

Cell Cycle & Senescence Cycle, Senescence & Post-Mitotic Control group encompasses regulation of cell division, checkpoint enforcement, cellular senescence, and aberrant cell-cycle re-entry in post-mitotic cells. It is critical for cancer proliferation contro" style="cursor:help;color:#555;font-weight:normal;">ⓘ

CDK1↓, 3,   CDK1↑, 1,   CDK2↓, 1,   Cyc↓, 12,   Cyc↝, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↝, 1,   P21↓, 1,   P21↑, 5,   P21↝, 1,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State ⓘ

BRAF↝, 1,   CD133↓, 1,   CSCs↓, 1,   p‑ERK↓, 1,   p‑ERK⇅, 1,   Gli1↓, 1,   HDAC↓, 2,   HH↓, 1,   IGF-1↓, 2,   mTOR↝, 1,   p‑mTOR↓, 1,   n-MYC↓, 1,   Nestin↓, 1,   NOTCH2↓, 1,   PI3K↝, 1,   PTEN↑, 1,   PTEN↝, 2,   Shh↓, 1,   Smo↓, 1,   SOX2↓, 1,   Sufu↑, 1,   TOP1↓, 1,   TumCG↓, 2,  

Migration ⓘ

AP-1↝, 1,   Ca+2↑, 1,   CAFs/TAFs↓, 1,   CDK4/6↓, 1,   E-cadherin↑, 1,   GLI2↓, 1,   MMP2↓, 2,   MMP2↝, 1,   MMP9↓, 2,   MMPs↓, 1,   N-cadherin↓, 1,   NCAM↓, 1,   ROCK1↓, 1,   Sharpin↓, 1,   Snail↓, 2,   TumCI↓, 1,   TumCMig↓, 2,   TumCP↓, 3,   Twist↓, 1,   Vim↓, 2,   β-catenin/ZEB1↓, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   ATF4↑, 1,   EGFR↝, 1,   HIF-1↓, 1,   VEGF↓, 3,   VEGF↝, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   COX2↝, 1,   IL1↓, 1,   IL6↓, 1,   IL6↝, 1,   Inflam↓, 1,   NF-kB↓, 3,   NF-kB↝, 1,   PD-L1↓, 1,   PSA↓, 2,   PSA↝, 1,   TNF-α↓, 1,   TNF-α↝, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↝, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 3,   eff↑, 2,   RadioS↑, 2,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

AR↝, 1,   BRAF↝, 1,   EGFR↝, 1,   IL6↓, 1,   IL6↝, 1,   PD-L1↓, 1,   PSA↓, 2,   PSA↝, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   neuroP↑, 1,   Risk↓, 1,   TumVol↓, 1,  
Total Targets: 172

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

chemoPv↑, 1,  

Redox & Oxidative Stress ⓘ

Catalase↑, 1,   GPx↑, 1,   SAM-e↑, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↝, 1,  

Core Metabolism/Glycolysis ⓘ

NAD↝, 1,  

Protein Folding & ER Stress ⓘ

HSP70/HSPA5↑, 1,  

Migration ⓘ

Ca+2↝, 1,   LAMs↑, 1,   serineP↓, 1,   Smad1↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,   TNF-α↓, 1,   VitD↑, 1,  

Hormonal & Nuclear Receptors ⓘ

testos↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   Dose↑, 1,   Dose↝, 1,   eff↑, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,   BMPs↑, 1,   Calcium↑, 1,   hs-CRP↓, 1,   Mag↑, 1,   VitD↑, 1,  

Functional Outcomes ⓘ

chemoP↑, 1,   ChemoSideEff↓, 1,   cognitive↑, 1,   memory↑, 1,   neuroP↑, 1,   Risk↓, 1,   toxicity↓, 1,  
Total Targets: 34

Scientific Paper Hit Count for: Cyc, Cyclin
3 Boron
2 Apigenin (mainly Parsley)
1 Alpha-Lipoic-Acid
1 Cisplatin
1 Baicalein
1 Berberine
1 Betulinic acid
1 Curcumin
1 Ursolic acid
1 Graviola
1 Hydroxycinnamic-acid
1 Methylene blue
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:374  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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