Database Query Results : , , Sufu

Sufu, Sufu gene: Click to Expand ⟱
Source:
Type: Gene
A mutation in the SUFU gene, this means you have a condition called Gorlin syndrome or nevoid basal cell carcinoma syndrome (NBCCS).
The expression levels of SUFU were significantly decreased in gastric cancer cells and the tumor tissues of gastric cancer patients.
Sufu is a key negative regulator of the Hedgehog (Hh) signaling pathway, which is involved in cell differentiation, proliferation, and tissue patterning.
• By inhibiting Gli transcription factors downstream of Hh signaling, Sufu helps moderate pathway activity.
• Aberrant Hh pathway activation—often through genetic or epigenetic disruption of Sufu—has been implicated in the development and progression of various cancers.

Sufu serves as a negative regulator of the Hh pathway, and its reduced expression or loss-of-function mutations can result in increased Hh signaling, promoting tumorigenesis.
Scientific Papers found: Click to Expand⟱
19- Deg,    Deguelin inhibits proliferation and migration of human pancreatic cancer cells in vitro targeting hedgehog pathway
- in-vitro, PC, Bxpc-3 - in-vitro, PC, PANC1
HH↓, Gli1↓, PTCH1↓, Sufu↓, MMP2↓, MMP9↓, PI3K/Akt↓, HIF-1↓, VEGF↓, IKKα↓, NF-kB↓, EMT↓, AMPK↑, mTOR↓, survivin↓,
843- Gra,    Graviola (Annona muricata) Exerts Anti-Proliferative, Anti-Clonogenic and Pro-Apoptotic Effects in Human Non-Melanoma Skin Cancer UW-BCC1 and A431 Cells In Vitro: Involvement of Hedgehog Signaling
- in-vitro, NMSC, A431 - in-vitro, NMSC, UW-BCC1 - in-vitro, Nor, NHEKn
TumCG↓, TumCCA↑, Cyc↓, Apoptosis↑, cl‑Casp3↑, cl‑Casp8↑, cl‑PARP↑, HH↓, Smo↓, Gli1↓, GLI2↓, Shh↓, Sufu↑, BAX↑, Bcl-2↓, *toxicity↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   PI3K/Akt↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   cl‑Casp3↑, 1,   cl‑Casp8↑, 1,   survivin↓, 1,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

Cyc↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   Gli1↓, 2,   HH↓, 2,   mTOR↓, 1,   PTCH1↓, 1,   Shh↓, 1,   Smo↓, 1,   Sufu↓, 1,   Sufu↑, 1,   TumCG↓, 1,  

Migration ⓘ

GLI2↓, 1,   MMP2↓, 1,   MMP9↓, 1,  

Angiogenesis & Vasculature ⓘ

HIF-1↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

IKKα↓, 1,   NF-kB↓, 1,  
Total Targets: 28

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: Sufu, Sufu gene
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:375  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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