Database Query Results : , , AR-FL

AR-FL, full-length androgen receptor: Click to Expand ⟱
Source:
Type:
AR-FL is the main therapeutic target in PCa, and the upregulated expression of this key biomarker has been reported in numerous cell line and clinical specimen, especially CRPC.
In prostate and other androgen-responsive tissues, AR-FL:
-Binds androgen in the cytoplasm
-Translocates to the nucleus
-Dimerizes and binds androgen response elements (AREs)
-Activates transcription programs controlling:
   -Differentiation
   -Survival
   -Controlled proliferation
   -Secretory function

AR-FL is therefore a lineage-defining transcription factor, not just a growth signal.


Scientific Papers found: Click to Expand⟱
75- QC,    Quercetin targets hnRNPA1 to overcome enzalutamide resistance in prostate cancer cells
- in-vitro, Pca, HEK293 - in-vitro, NA, 22Rv1 - in-vitro, NA, C4-2B
hnRNPA1↓, PSA↓, NKX3.1↓, FKBP5↓, UBE2C↓, AR-FL↓, AR-V7↑, AR↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


DNA Damage & Repair ⓘ

NKX3.1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

AR-FL↓, 1,   AR-V7↑, 1,  

Migration ⓘ

hnRNPA1↓, 1,  

Immune & Inflammatory Signaling ⓘ

PSA↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   FKBP5↓, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,   PSA↓, 1,  

Functional Outcomes ⓘ

UBE2C↓, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: AR-FL, full-length androgen receptor
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:392  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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