Database Query Results : , , AR-V7

AR-V7, androgen receptor splice variant 7: Click to Expand ⟱
Source:
Type:
Accumulating evidence suggests androgen receptor splice variant 7 (AR-V7) may be associated with the prognosis of castration-resistant prostate cancer (CRPC).
AR-V7 is primarily studied in prostate cancer, where it has established prognostic significance. Prostate Cancer
Expression: AR-V7 is often overexpressed in castration-resistant prostate cancer (CRPC). Prognosis: High levels of AR-V7 are associated with poor prognosis, treatment resistance, and shorter overall survival. It is also used as a biomarker to predict response to therapies like enzalutamide and abiraterone.
Scientific Papers found: Click to Expand⟱
2783- CHr,    Apoptotic Effects of Chrysin in Human Cancer Cell Lines
- Review, Var, NA
TumCP↓, Apoptosis↑, Casp↑, PCNA↓, p38↑, NF-kB↑, DNAdam↑, XIAP↓, Cyt‑c↑, Casp3↑, Akt↓, SCF↓, hTERT/TERT↓, COX2↓, *Inflam↓, *antiOx↑, *chemoPv↑, AR-V7?, CYP19?,
75- QC,    Quercetin targets hnRNPA1 to overcome enzalutamide resistance in prostate cancer cells
- in-vitro, Pca, HEK293 - in-vitro, NA, 22Rv1 - in-vitro, NA, C4-2B
hnRNPA1↓, PSA↓, NKX3.1↓, FKBP5↓, UBE2C↓, AR-FL↓, AR-V7↑, AR↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

XIAP↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,   Casp↑, 1,   Casp3↑, 1,   Cyt‑c↑, 1,   hTERT/TERT↓, 1,   p38↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   NKX3.1↓, 1,   PCNA↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

AR-FL↓, 1,   AR-V7?, 1,   AR-V7↑, 1,   SCF↓, 1,  

Migration ⓘ

hnRNPA1↓, 1,   TumCP↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   NF-kB↑, 1,   PSA↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CYP19?, 1,   FKBP5↓, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,   hTERT/TERT↓, 1,   PSA↓, 1,  

Functional Outcomes ⓘ

UBE2C↓, 1,  
Total Targets: 27

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

chemoPv↑, 1,  

Redox & Oxidative Stress ⓘ

antiOx↑, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,  
Total Targets: 3

Scientific Paper Hit Count for: AR-V7, androgen receptor splice variant 7
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:393  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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