Database Query Results : , , aSmase

aSmase, Acid Sphingomyelinase: Click to Expand ⟱
Source:
Type:
A-SMase expression correlates inversely with tumour stage in human melanoma biopsies.In melanoma, expression of acid sphingomyelinase decreases with tumor progression in both humans and mice. A-SMase expression correlates inversely with tumour stage in human melanoma biopsies.

The SMase family includes different isoenzymes mainly distinguished by their optimal pH:
-Acid sphingomyelinase (aSMase):Encoded by the gene SMPD1.Functions optimally at acidic pH.
-Neutral sphingomyelinases (nSMases):(nSMase1, nSMase2, nSMase3) encoded by genes SMPD2, SMPD3.
-Alkaline sphingomyelinases: typically found in the intestinal tract.

aSMase expression or activity is reduced compared to normal tissue. Lower aSMase activity can lead to decreased ceramide generation, potentially allowing cancer cells to avoid apoptosis.

In many cancer-related studies where the term “SMase” is used without further specification, the discussion may center on aSMase because of its link to ceramide production and apoptosis under stress conditions (such as chemotherapy or radiotherapy).
Scientific Papers found: Click to Expand⟱
1515- EGCG,  Phen,    Reciprocal Relationship Between Cytosolic NADH and ENOX2 Inhibition Triggers Sphingolipid-Induced Apoptosis in HeLa Cells
- in-vitro, Cerv, HeLa - in-vitro, Nor, MCF10 - in-vitro, BC, BT20
selectivity↑, ENOX2↓, NADH↑, SK↓, eff↑, aSmase↑,
76- QC,    Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy
- in-vitro, Pca, PC3
aSmase↝, Diablo↝, Fas↝, Hsc70↝, Hif1a↝, Mcl-1↝, HSP90↝, FLT4↝, EphB4↝, DNA-PK↝, PARP1↝, ATM↝, XIAP↝, PLC↝, GnT-V↝, heparanase↝, NM23↝, CSR1↝, SPP1↝, DNMT1↝, HDAC4↝, CXCR4↝, β-catenin/ZEB1↝, FBXW7↝, AMACR↝, cycD1/CCND1↝, IGF-1R↝, IMPDH1↝, IMPDH2↝, HEC1↝, NHE1↝, NOS2↝,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ENOX2↓, 1,   NADH↑, 1,  

Mitochondria & Bioenergetics ⓘ

XIAP↝, 1,  

Core Metabolism/Glycolysis ⓘ

AMACR↝, 1,  

Cell Death ⓘ

aSmase↑, 1,   aSmase↝, 1,   CSR1↝, 1,   Diablo↝, 1,   Fas↝, 1,   Mcl-1↝, 1,   SK↓, 1,  

Transcription & Epigenetics ⓘ

SPP1↝, 1,  

Protein Folding & ER Stress ⓘ

Hsc70↝, 1,   HSP90↝, 1,  

DNA Damage & Repair ⓘ

ATM↝, 1,   DNA-PK↝, 1,   DNMT1↝, 1,   PARP1↝, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↝, 1,  

Proliferation, Differentiation & Cell State ⓘ

FBXW7↝, 1,   HDAC4↝, 1,   IGF-1R↝, 1,  

Migration ⓘ

EphB4↝, 1,   GnT-V↝, 1,   heparanase↝, 1,   NM23↝, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature ⓘ

FLT4↝, 1,   Hif1a↝, 1,  

Barriers & Transport ⓘ

NHE1↝, 1,  

Immune & Inflammatory Signaling ⓘ

CXCR4↝, 1,  

Cellular Microenvironment ⓘ

PLC↝, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

HEC1↝, 1,   NOS2↝, 1,  

Functional Outcomes ⓘ

IMPDH1↝, 1,   IMPDH2↝, 1,  
Total Targets: 38

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: aSmase, Acid Sphingomyelinase
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:394  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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