Database Query Results : , , EphB4

EphB4, tyrosine kinase EphB4: Click to Expand ⟱
Source:
Type:
Eph receptors and their Eph receptor-interacting (ephrin) ligands together form an important cell communication system with diverse roles.
High EPHB4 expression correlates with advanced prostate cancer stage and poor outcome.
EphB4 is often upregulated in cancer, and its expression may be linked to tumor progression and poor prognosis.
Scientific Papers found: Click to Expand⟱
76- QC,    Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy
- in-vitro, Pca, PC3
aSmase↝, Diablo↝, Fas↝, Hsc70↝, Hif1a↝, Mcl-1↝, HSP90↝, FLT4↝, EphB4↝, DNA-PK↝, PARP1↝, ATM↝, XIAP↝, PLC↝, GnT-V↝, heparanase↝, NM23↝, CSR1↝, SPP1↝, DNMT1↝, HDAC4↝, CXCR4↝, β-catenin/ZEB1↝, FBXW7↝, AMACR↝, cycD1/CCND1↝, IGF-1R↝, IMPDH1↝, IMPDH2↝, HEC1↝, NHE1↝, NOS2↝,
1210- SANG,    Sanguinarine combats hypoxia-induced activation of EphB4 and HIF-1α pathways in breast cancer
- in-vitro, BC, NA
EphB4↓, Hif1a↓, STAT3↓, MAPK↓, ERK↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

XIAP↝, 1,  

Core Metabolism/Glycolysis ⓘ

AMACR↝, 1,  

Cell Death ⓘ

aSmase↝, 1,   CSR1↝, 1,   Diablo↝, 1,   Fas↝, 1,   MAPK↓, 1,   Mcl-1↝, 1,  

Transcription & Epigenetics ⓘ

SPP1↝, 1,  

Protein Folding & ER Stress ⓘ

Hsc70↝, 1,   HSP90↝, 1,  

DNA Damage & Repair ⓘ

ATM↝, 1,   DNA-PK↝, 1,   DNMT1↝, 1,   PARP1↝, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↝, 1,  

Proliferation, Differentiation & Cell State ⓘ

ERK↓, 1,   FBXW7↝, 1,   HDAC4↝, 1,   IGF-1R↝, 1,   STAT3↓, 1,  

Migration ⓘ

EphB4↓, 1,   EphB4↝, 1,   GnT-V↝, 1,   heparanase↝, 1,   NM23↝, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature ⓘ

FLT4↝, 1,   Hif1a↓, 1,   Hif1a↝, 1,  

Barriers & Transport ⓘ

NHE1↝, 1,  

Immune & Inflammatory Signaling ⓘ

CXCR4↝, 1,  

Cellular Microenvironment ⓘ

PLC↝, 1,  

Clinical Biomarkers ⓘ

HEC1↝, 1,   NOS2↝, 1,  

Functional Outcomes ⓘ

IMPDH1↝, 1,   IMPDH2↝, 1,  
Total Targets: 37

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: EphB4, tyrosine kinase EphB4
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:398  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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