Database Query Results : , , HSD3B

HSD3B, HSD3B: Click to Expand ⟱
Source:
Type:
Also 3BHS1, 3BH, HSDB3, and HSD3B
HSD3B refers to 3β-hydroxysteroid dehydrogenase, an enzyme that plays a critical role in steroid hormone biosynthesis. There are several isoforms of this enzyme, with HSD3B1 and HSD3B2 being the most studied. These enzymes catalyze the conversion of pregnenolone to progesterone and the conversion of dehydroepiandrosterone (DHEA) to androstenedione, which are important steps in the synthesis of various steroid hormones.
HSD3B1 is a gene that encodes an enzyme involved in steroid hormone biosynthesis and metabolism.

HSD3B expression has been observed in various cancers, particularly those that are hormone-dependent, such as breast, prostate, and ovarian cancers.
HSD3B is involved in steroid hormone biosynthesis and has been implicated in various cancers, particularly hormone-dependent tumors. Its expression levels may have prognostic significance, and while it is not classified as an oncogene, its role in hormone metabolism can influence cancer progression and treatment response
Scientific Papers found: Click to Expand⟱
131- CUR,    Modulation of AKR1C2 by curcumin decreases testosterone production in prostate cancer
- vitro+vivo, Pca, LNCaP - vitro+vivo, Pca, 22Rv1
AKR1C2↓, CYP11A1↓, HSD3B↓, DHT↓, testos↓, StAR↓, SRD5A1↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Migration ⓘ

AKR1C2↓, 1,  

Hormonal & Nuclear Receptors ⓘ

CYP11A1↓, 1,   DHT↓, 1,   HSD3B↓, 1,   SRD5A1↑, 1,   StAR↓, 1,   testos↓, 1,  
Total Targets: 7

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: HSD3B, HSD3B
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:455  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page