Database Query Results : , , testos

testos, testosterone: Click to Expand ⟱
Source:
Type:
Hormone therapy — slows cancer growth by lowering testosterone levels in the body.
"shaking up prostate cancer with high-dose testosterone makes it more vulnerable to other treatments."
testosterone-levels-in-men-with-prostate-cancer" >There is a higher incidence of prostate cancer among men with low testosterone.

Prostate cancer is highly sensitive to androgenic stimulation. Testosterone—and more potently, its derivative dihydrotestosterone (DHT)—binds to the androgen receptor (AR) in prostate cells, which can drive the growth and survival of both normal and malignant cells.

Castration-Resistant Prostate Cancer (CRPC):

Even after testosterone levels are medically reduced, some prostate cancers continue to thrive by adapting their AR pathway. CRPC often signals a transition to a more aggressive, treatment-resistant state.
Scientific Papers found: Click to Expand⟱
4620- Bor,  BTZ,    Boron Compounds in the Breast Cancer Cells Chemoprevention and Chemotherapy
- Review, Var, NA - Review, Arthritis, NA - Review, Pca, NA
Risk↓, *memory↑, *Dose↑, Risk↓, other↝, *testos↑, other↝, Risk↓, TumCP↓, Apoptosis↑, eff↑,
696- Bor,    Nothing Boring About Boron
- Review, Var, NA
*hs-CRP↓, *TNF-α↓, *SOD↑, *Catalase↑, *GPx↑, *cognitive↑, *memory↑, *Risk↓, *SAM-e↑, *NAD↝, *ATP↝, *Ca+2↝, HDAC↓, TumVol↓, IGF-1↓, PSA↓, Cyc↓, TumCMig↓, *serineP↓, HIF-1↓, *ChemoSideEff↓, *VitD↑, *Mag↑, *eff↑, Risk↓, *Inflam↓, *neuroP↑, *Calcium↑, *BMD↑, *chemoP↑, AntiCan↑, *Dose↑, *Dose↝, *BMPs↑, *testos↑, angioG↓, Apoptosis↑, *selectivity↑, *chemoPv↑,
131- CUR,    Modulation of AKR1C2 by curcumin decreases testosterone production in prostate cancer
- vitro+vivo, Pca, LNCaP - vitro+vivo, Pca, 22Rv1
AKR1C2↓, CYP11A1↓, HSD3B↓, DHT↓, testos↓, StAR↓, SRD5A1↑, AR↓, tumCV↓, TumCG↓, Apoptosis↑,
5055- Ex,    Why exercise has a crucial role in cancer prevention, risk reduction and improved outcomes
- Review, Var, NA
OS↑, IGF-1↓, IGFBP3↑, BRCA1↑, BRCA2↑, RAS↓, P53↑, HSPs↑, Leptin↓, Irisin↓, Resistin↓, NK cell↑, CRP↓, IL6↓, TNF-α↓, PGE1↓, COX2↓, *GSH↑, *Catalase↑, *SOD↑, *monoA↑, *EndoR↑, *testos↑, ROS↑, QoL↑, BMD↑, BowelM↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

Irisin↓, 1,   Leptin↓, 1,   Resistin↓, 1,  

Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Cell Death ⓘ

Apoptosis↑, 3,  

Transcription & Epigenetics ⓘ

BowelM↑, 1,   other↝, 2,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

HSPs↑, 1,  

DNA Damage & Repair ⓘ

BRCA1↑, 1,   BRCA2↑, 1,   P53↑, 1,  

Cell Cycle & Senescence ⓘ

Cyc↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

HDAC↓, 1,   IGF-1↓, 2,   IGFBP3↑, 1,   RAS↓, 1,   TumCG↓, 1,  

Migration ⓘ

AKR1C2↓, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   HIF-1↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,   CRP↓, 1,   IL6↓, 1,   NK cell↑, 1,   PGE1↓, 1,   PSA↓, 1,   TNF-α↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CYP11A1↓, 1,   DHT↓, 1,   HSD3B↓, 1,   SRD5A1↑, 1,   StAR↓, 1,   testos↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Clinical Biomarkers ⓘ

AR↓, 1,   BMD↑, 1,   BRCA1↑, 1,   CRP↓, 1,   IL6↓, 1,   PSA↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   OS↑, 1,   QoL↑, 1,   Risk↓, 4,   TumVol↓, 1,  
Total Targets: 49

Pathway results for Effect on Normal Cells:


NA, unassigned ⓘ

EndoR↑, 1,  

Redox & Oxidative Stress ⓘ

Catalase↑, 2,   GPx↑, 1,   GSH↑, 1,   SAM-e↑, 1,   SOD↑, 2,  

Mitochondria & Bioenergetics ⓘ

ATP↝, 1,  

Core Metabolism/Glycolysis ⓘ

NAD↝, 1,  

Migration ⓘ

Ca+2↝, 1,   serineP↓, 1,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,   TNF-α↓, 1,   VitD↑, 1,  

Synaptic & Neurotransmission ⓘ

monoA↑, 1,  

Hormonal & Nuclear Receptors ⓘ

testos↑, 3,  

Drug Metabolism & Resistance ⓘ

Dose↑, 2,   Dose↝, 1,   eff↑, 1,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

BMD↑, 1,   BMPs↑, 1,   Calcium↑, 1,   hs-CRP↓, 1,   Mag↑, 1,   VitD↑, 1,  

Functional Outcomes ⓘ

chemoP↑, 1,   chemoPv↑, 1,   ChemoSideEff↓, 1,   cognitive↑, 1,   memory↑, 2,   neuroP↑, 1,   Risk↓, 1,  
Total Targets: 32

Scientific Paper Hit Count for: testos, testosterone
2 Boron
1 Bortezomib
1 Curcumin
1 Exercise
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:458  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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