| Source: |
| Type: gene/protein |
| Also called CD71 A protein that in humans is encoded by the TFRC gene. A protein that mediates iron uptake from transferrin into cells. Transferrin receptor, which can control iron metabolism, is frequently expressed in tumor cells. As is well known, TfR1 binds to iron-loaded transferrin and plays a pivotal role in cellular uptake of iron as well as ferritin sequesters and stores the cellular iron. |
| 1069- | AL, | Allicin promotes autophagy and ferroptosis in esophageal squamous cell carcinoma by activating AMPK/mTOR signaling |
| - | vitro+vivo, | ESCC, | TE1 | - | vitro+vivo, | ESCC, | KYSE-510 | - | in-vitro, | Nor, | Het-1A |
| 557- | ART/DHA, | Artemisinin and Its Derivatives in Cancer Care |
| - | Review, | Var, | NA |
| 576- | ART/DHA, | Profiling of Multiple Targets of Artemisinin Activated by Hemin in Cancer Cell Proteome |
| - | Analysis, | NA, | NA |
| 3679- | BBR, | Berberine alleviates Alzheimer's disease by activating autophagy and inhibiting ferroptosis through the JNK-p38MAPK signaling pathway |
| - | in-vivo, | AD, | NA |
| 135- | CUR, | Curcumin induces apoptosis and protective autophagy in castration-resistant prostate cancer cells through iron chelation |
| - | in-vitro, | Pca, | DU145 | - | in-vitro, | Pca, | PC3 |
| 673- | EGCG, | Iron Chelation Properties of Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Analysis on Tfr/Fth Regulations and Molecular Docking |
| - | in-vitro, | CRC, | HT-29 |
| 2426- | GamB, | Anti-cancer natural products isolated from chinese medicinal herbs |
| - | Review, | Var, | NA |
| 4213- | Hup, | Huperzine A-Liposomes Efficiently Improve Neural Injury in the Hippocampus of Mice with Chronic Intermittent Hypoxia |
| - | in-vivo, | NA, | NA |
| 4209- | Hup, | Huperzine A, reduces brain iron overload and alleviates cognitive deficit in mice exposed to chronic intermittent hypoxia |
| - | in-vivo, | NA, | NA |
| 3803- | Hup, | Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease |
| - | Review, | AD, | NA |
| 222- | MFrot, | MF, | LF-MF inhibits iron metabolism and suppresses lung cancer through activation of P53-miR-34a-E2F1/E2F3 pathway |
| - | in-vitro, | Lung, | A549 |
| 4927- | PEITC, | Targeting ferroptosis in osteosarcoma |
| - | Review, | OS, | NA |
| 3039- | RosA, | Rosmarinic acid liposomes suppress ferroptosis in ischemic brain via inhibition of TfR1 in BMECs |
| - | in-vivo, | Nor, | NA | - | in-vivo, | Stroke, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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