Database Query Results : , , BID

BID, BH3 interacting-domain death agonist: Click to Expand ⟱
Source:
Type: pro-apoptotic protein
Bid is an abundant pro-apoptotic protein of the Bcl-2 family that is crucial for death receptor-mediated apoptosis in many cell systems.
The expression of BID can serve as a prognostic marker in several cancers. Higher levels of BID are often associated with increased apoptosis and better treatment responses, while lower levels may indicate resistance to therapy and poorer outcomes.

Generation of Truncated Bid (tBid):
• When apoptosis is signaled, specific proteases (such as caspase-8) cleave full-length Bid into its truncated form, tBid.
• tBid is the active form that translocates to mitochondria.

So "the truncation of Bid" means that the protein has been converted into an active form (tBid) that supports apoptosis.
Scientific Papers found: Click to Expand⟱
2634- Api,    Apigenin induces both intrinsic and extrinsic pathways of apoptosis in human colon carcinoma HCT-116 cells
- in-vitro, CRC, HCT116
TumCG↓, TumCCA↑, MMP↓, ROS↑, Ca+2↑, ER Stress↑, mtDam↑, CHOP↑, DR5↑, cl‑BID↑, BAX↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, Apoptosis↑,
1521- Ba,    Baicalein induces apoptosis via ROS-dependent activation of caspases in human bladder cancer 5637 cells
- in-vitro, Bladder, 5637
TumCG↓, Apoptosis↑, IAP1↓, IAP2↓, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, MMP↓, Casp8↑, BID↑, ROS?, eff↓, DR4↑, DR5↑, FasL↑, TRAIL↑,
1524- Ba,    Baicalein Induces Caspase‐dependent Apoptosis Associated with the Generation of ROS and the Activation of AMPK in Human Lung Carcinoma A549 Cells
- in-vitro, Lung, A549
DR5↑, FADD↑, FasL↑, Casp8↑, cFLIP↓, Casp3↑, Casp9↑, cl‑PARP↑, MMP↓, BID↑, Cyt‑c↑, ROS↑, eff↓, AMPK↑, Apoptosis↑, TumCCA↑, DR5↑, FasL↑, DR4∅, cFLIP↓, FADD↑, MMPs↓,
1526- Ba,    Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells
- in-vitro, AML, HL-60
Apoptosis↑, cl‑PARP↑, DNAdam↑, cl‑BID↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9?, H2O2↑, ROS↑,
2476- Ba,    Baicalein Induces Caspase-dependent Apoptosis Associated with the Generation of ROS and the Activation of AMPK in Human Lung Carcinoma A549 Cells
- in-vitro, Lung, A549
TumCG↓, Apoptosis↑, DR5↑, FasL↑, FADD↑, Casp8↑, cFLIP↓, Casp9↑, Casp3↑, cl‑PARP↑, MMP↓, BID↑, BAX↑, Cyt‑c↑, ROS↑, eff↓, AMPK↑,
726- Bor,    Redox Mechanisms Underlying the Cytostatic Effects of Boric Acid on Cancer Cells—An Issue Still Open
- Review, NA, NA
NAD↝, SAM-e↝, PSA↓, IGF-1↓, Cyc↓, P21↓, p‑MEK↓, p‑ERK↓, ROS↑, SOD↓, Catalase↓, MDA↑, GSH↓, IL1↓, IL6↓, TNF-α↓, BRAF↝, MAPK↝, PTEN↝, PI3K/Akt↝, eIF2α↑, ATF4↑, ATF6↑, NRF2↑, BAX↑, BID↑, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓,
1652- CA,    Caffeic Acid and Diseases—Mechanisms of Action
- Review, Var, NA
Dose∅, ROS⇅, NF-kB↓, STAT3↓, VEGF↓, MMP9↓, HSP70/HSPA5↑, AST↝, ALAT↝, ALP↝, Hif1a↓, IL6↓, IGF-1R↓, P21↑, iNOS↓, ERK↓, Snail↓, BID↑, BAX↑, Casp3↑, Casp7↑, Casp9↑, cycD1/CCND1↓, Vim↓, β-catenin/ZEB1↓, COX2↓, ROS↑,
1145- CHr,    Chrysin inhibits propagation of HeLa cells by attenuating cell survival and inducing apoptotic pathways
- in-vitro, Cerv, HeLa
tumCV↓, BAX↑, BID↑, BOK↑, APAF1↑, TNF-α↑, FasL↑, Fas↑, FADD↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Mcl-1↓, NAIP↓, Bcl-2↓, CDK4↓, CycB/CCNB1↓, cycD1/CCND1↓, cycE1↓, TRAIL↑, p‑Akt↓, Akt↓, mTOR↓, PDK1↓, BAD↓, GSK‐3β↑, AMPK↑, p27↑, P53↑,
136- CUR,  docx,    Combinatorial effect of curcumin with docetaxel modulates apoptotic and cell survival molecules in prostate cancer
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
Bcl-2↓, Bcl-xL↓, Mcl-1↓, BAX↑, BID↑, PARP↑, NF-kB↓, CDK1↓, COX2↓, RTK-RAS↓, PI3K/Akt↓, EGFR↓, HER2/EBBR2↓, P53↑,
3204- EGCG,    The Role of ER Stress and the Unfolded Protein Response in Cancer
- Review, Var, NA
BID↓, UPR↑, ER Stress↑,
1155- F,    The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations
- Review, NA, NA
*toxicity↓, Casp3↑, Casp7↑, Casp8↑, Casp9↑, VEGF↓, angioG↓, PI3K↓, Akt↓, PARP↑, Bak↑, BID↑, Fas↑, Mcl-1↓, survivin↓, XIAP↓, ERK↓, EMT↓, EM↑, IM↓, Snail↓, Slug↓, Twist↓,
2832- FIS,    Fisetin's Promising Antitumor Effects: Uncovering Mechanisms and Targeting for Future Therapies
- Review, Var, NA
MMP↓, mtDam↑, Cyt‑c↑, Diablo↑, Casp↑, cl‑PARP↑, Bak↑, BIM↑, Bcl-xL↓, Bcl-2↓, P53↑, ROS↑, AMPK↑, Casp9↑, Casp3↑, BID↑, AIF↑, Akt↓, mTOR↓, MAPK↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, P21↑, p27↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, TumMeta↓, uPA↓, E-cadherin↑, Vim↓, EMT↓, Twist↓, DNAdam↑, ROS↓, COX2↓, PGE2↓, HSF1↓, cFos↓, cJun↓, AP-1↓, Mcl-1↓, NF-kB↓, IRE1↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MMP2↓, MMP9↓, TCF-4↓, MMP7↓, RadioS↑, TOP1↓, TOP2↓,
2912- LT,    Luteolin: a flavonoid with a multifaceted anticancer potential
- Review, Var, NA
ROS↑, TumCCA↑, TumCP↓, angioG↓, ER Stress↑, mtDam↑, PERK↑, ATF4↑, eIF2α↑, cl‑Casp12↑, EMT↓, E-cadherin↑, N-cadherin↓, Vim↓, *neuroP↑, NF-kB↓, PI3K↓, Akt↑, XIAP↓, MMP↓, Ca+2↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, Cyt‑c↑, IronCh↑, SOD↓, *ROS↓, *LDHA↑, *SOD↑, *GSH↑, *BioAv↓, Telomerase↓, cMyc↓, hTERT/TERT↓, DR5↑, Fas↑, FADD↑, BAD↑, BOK↑, BID↑, NAIP↓, Mcl-1↓, CDK2↓, CDK4↓, MAPK↓, AKT1↓, Akt2↓, *Beclin-1↓, Hif1a↓, LC3II↑, Beclin-1↑,
2076- PB,    Sodium Butyrate Induces Endoplasmic Reticulum Stress and Autophagy in Colorectal Cells: Implications for Apoptosis
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29
TumCP↓, TumAuto↑, Apoptosis↑, ER Stress↑, BID↑, CHOP↑, PDI↑, IRE1↓, LC3‑Ⅱ/LC3‑Ⅰ↑, LC3B↑, Beclin-1↑, other↝, other↝,
4923- PEITC,    Quantitative chemical proteomics reveals that phenethyl isothiocyanate covalently targets BID to promote apoptosis
- Study, Var, NA
cl‑BID↑, Apoptosis↑, Bcl-xL↓, Casp8↑, Cyt‑c↑,
4940- PEITC,    Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G 0/G 1 Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death
- in-vitro, Oral, HSC3
TumCCA↑, Apoptosis↑, BAX↑, BID↑, Bcl-2↓, MMP↓, Cyt‑c↑, AIF↑, tumCV↓, ROS↑, Ca+2↑, CDC25↓, CDK6↓, cycD1/CCND1↓, CDK2↓, cycE/CCNE↓, P53↑, p27↑, P21↑, Casp9↑, Casp3↑, GRP78/BiP↑,
4947- PEITC,    Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G0/G1   Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death
- in-vitro, Oral, HSC3
AntiCan↑, chemoPv↑, TumCG↓, Apoptosis↑, TumCCA↑, P53↑, P21↑, BAX↑, BID↑, Bcl-2↓, MMP↓, Cyt‑c↑, AIF↑, ROS↑, Ca+2↑,
4942- PEITC,    Phenethyl Isothiocyanate (PEITC) Inhibits the Growth of Human Oral Squamous Carcinoma HSC-3 Cells through G(0)/G(1) Phase Arrest and Mitochondria-Mediated Apoptotic Cell Death
- in-vitro, Oral, HSC3
chemoPv↑, TumCG↓, TumCCA↑, Apoptosis↑, BAX↑, BID↑, Bcl-2↓, MMP↓, Cyt‑c↑, AIF↑, ROS↑, Ca+2↑,
3192- SFN,    Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention
- in-vitro, Pca, PC3
Sp1/3/4↓, selectivity↑, NRF2↑, HDAC↓, DNMTs↓, TumCCA↑, selectivity↑, HO-1↑, NQO1↑, CDK2↓, TumCP↓, BID↑, Smad1↑, Diablo↑, ICAD↑, Cyt‑c↑, IAP1↑, HSP27↑, *Cyt‑c↓, *IAP1↓, *HSP27↓, survivin↓, CDK4↓, VEGF↓, AR↓,
1465- SFN,    TRAIL attenuates sulforaphane-mediated Nrf2 and sustains ROS generation, leading to apoptosis of TRAIL-resistant human bladder cancer cells
- NA, Bladder, NA
eff↑, Apoptosis↑, Casp↑, MMP↓, BID↑, DR5↑, ROS↑, NRF2↑, eff↑, eff↓,
978- SIL,    A comprehensive evaluation of the therapeutic potential of silibinin: a ray of hope in cancer treatment
- Review, NA, NA
PI3K↓, Akt↓, NF-kB↓, Wnt/(β-catenin)↓, MAPK↓, TumCP↓, TumCCA↑, Apoptosis↑, p‑EGFR↓, JAK2↓, STAT5↓, cycD1/CCND1↓, hTERT/TERT↓, AP-1↓, MMP9↓, miR-21↓, miR-155↓, Casp9↑, BID↑, ERK↓, Akt2↓, DNMT1↓, P53↑, survivin↓, Casp3↑, ROS↑,
324- SNP,  CPT,    Silver Nanoparticles Potentiates Cytotoxicity and Apoptotic Potential of Camptothecin in Human Cervical Cancer Cells
- in-vitro, Cerv, HeLa
ROS↑, Casp3↑, Casp9↑, Casp6↑, GSH↓, SOD↓, GPx↓, MMP↓, P53↑, P21↑, Cyt‑c↑, BID↑, BAX↑, Bcl-2↓, Bcl-xL↓, Akt↓, Raf↓, ERK↓, MAP2K1/MEK1↓, JNK↑, p38↑,
4427- SNP,    Silver nanoparticles induce apoptosis and G2/M arrest via PKCζ-dependent signaling in A549 lung cells
- in-vitro, Lung, A549
tumCV↓, LDH↑, TumCCA↑, BAX↑, BID↑, Bcl-2↓, PKCδ↓,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27↑, P21↑, ChemoSen↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 24

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

chemoPv↑, 2,  

Redox & Oxidative Stress ⓘ

Catalase↓, 1,   GPx↓, 1,   GSH↓, 2,   H2O2↑, 1,   HO-1↑, 1,   MDA↑, 1,   NQO1↑, 1,   NRF2↑, 3,   ROS?, 1,   ROS↓, 1,   ROS↑, 14,   ROS⇅, 2,   SAM-e↝, 1,   SOD↓, 3,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 4,   BOK↑, 2,   CDC2↓, 1,   CDC25↓, 2,   p‑MEK↓, 1,   MMP↓, 11,   mtDam↑, 3,   Raf↓, 1,   XIAP↓, 3,  

Core Metabolism/Glycolysis ⓘ

AKT1↓, 1,   ALAT↝, 1,   AMPK↑, 5,   ATG7↑, 1,   cMyc↓, 1,   LDH↑, 1,   NAD↝, 1,   PDK1↓, 1,   PI3K/Akt↓, 1,   PI3K/Akt↝, 1,   PPARγ↑, 1,  

Cell Death ⓘ

Akt↓, 6,   Akt↑, 1,   p‑Akt↓, 1,   APAF1↑, 1,   Apoptosis↑, 12,   BAD↓, 1,   BAD↑, 1,   Bak↑, 2,   BAX↑, 13,   Bcl-2↓, 12,   Bcl-xL↓, 5,   BID↓, 2,   BID↑, 19,   cl‑BID↑, 3,   BIM↑, 1,   Casp↑, 2,   cl‑Casp12↑, 1,   Casp3↑, 14,   cl‑Casp3↑, 1,   Casp6↑, 1,   Casp7↑, 3,   Casp8↑, 8,   cl‑Casp8↑, 1,   Casp9?, 1,   Casp9↑, 13,   cl‑Casp9↑, 1,   cFLIP↓, 3,   Cyt‑c↑, 12,   Diablo↑, 2,   DR4↑, 1,   DR4∅, 1,   DR5↑, 8,   FADD↑, 5,   Fas↑, 4,   FasL↑, 5,   hTERT/TERT↓, 2,   IAP1↓, 1,   IAP1↑, 1,   IAP2↓, 1,   ICAD↑, 1,   iNOS↓, 2,   JNK↑, 2,   MAPK↓, 3,   MAPK↑, 1,   MAPK↝, 1,   Mcl-1↓, 6,   Myc↓, 1,   NAIP↓, 2,   p27↑, 4,   p38↑, 2,   survivin↓, 4,   Telomerase↓, 1,   TRAIL↑, 3,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,   RTK-RAS↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

cJun↓, 1,   miR-21↓, 1,   other↝, 2,   tumCV↓, 3,  

Protein Folding & ER Stress ⓘ

ATF6↑, 1,   CHOP↑, 2,   eIF2α↓, 1,   eIF2α↑, 2,   ER Stress↑, 5,   GRP78/BiP↑, 2,   HSF1↓, 1,   HSP27↑, 1,   HSP70/HSPA5↑, 1,   IRE1↓, 1,   IRE1↑, 1,   PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↑, 3,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   LC3B↑, 1,   LC3II↑, 2,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

CYP1B1↑, 1,   DNAdam↑, 2,   DNMT1↓, 2,   DNMTs↓, 1,   p16↑, 1,   P53↑, 8,   PARP↑, 2,   cl‑PARP↑, 4,   UHRF1↓, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK2↓, 5,   CDK4↓, 5,   Cyc↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 6,   cycE/CCNE↓, 2,   cycE1↓, 1,   E2Fs↓, 1,   P21↓, 1,   P21↑, 6,   TumCCA↑, 10,  

Proliferation, Differentiation & Cell State ⓘ

BRAF↝, 1,   cFos↓, 1,   cMET↓, 1,   EMT↓, 3,   ERK↓, 5,   p‑ERK↓, 1,   FOXO↑, 1,   GSK‐3β↓, 1,   GSK‐3β↑, 1,   HDAC↓, 1,   HDAC1↓, 1,   IGF-1↓, 1,   IGF-1R↓, 1,   MAP2K1/MEK1↓, 1,   mTOR↓, 3,   NOTCH↓, 1,   P70S6K↓, 1,   PI3K↓, 4,   PTEN↝, 1,   STAT3↓, 2,   STAT5↓, 1,   TCF-4↓, 1,   TOP1↓, 1,   TOP2↓, 1,   TumCG↓, 5,   Wnt↓, 2,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

5LO↓, 1,   Akt2↓, 2,   AP-1↓, 3,   Ca+2↑, 5,   DLC1↑, 1,   E-cadherin↑, 2,   EM↑, 1,   ITGA5↓, 1,   miR-155↓, 1,   MMP2↓, 2,   MMP7↓, 2,   MMP9↓, 4,   MMPs↓, 1,   N-cadherin↓, 2,   PKCδ↓, 1,   Slug↓, 2,   Smad1↑, 1,   Snail↓, 3,   TumCP↓, 4,   TumMeta↓, 1,   Twist↓, 3,   uPA↓, 1,   Vim↓, 4,   Zeb1↓, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   ATF4↑, 3,   EGFR↓, 1,   p‑EGFR↓, 1,   Hif1a↓, 2,   PDI↑, 1,   VEGF↓, 4,   VEGFR2↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 4,   CXCL1↓, 1,   CXCR4↓, 1,   IL1↓, 2,   IL10↓, 1,   IL12↓, 1,   IL2↑, 1,   IL6↓, 3,   JAK2↓, 2,   NF-kB↓, 6,   p65↓, 1,   PGE2↓, 1,   PSA↓, 1,   TNF-α↓, 2,   TNF-α↑, 1,  

Cellular Microenvironment ⓘ

IM↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 3,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   Dose∅, 1,   eff↓, 4,   eff↑, 2,   RadioS↑, 1,   selectivity↑, 2,   TET2↑, 1,  

Clinical Biomarkers ⓘ

ALAT↝, 1,   ALP↝, 1,   AR↓, 1,   AST↝, 1,   BRAF↝, 1,   EGFR↓, 1,   p‑EGFR↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 2,   IL6↓, 3,   LDH↑, 1,   Myc↓, 1,   PSA↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,  
Total Targets: 235

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

GSH↑, 1,   ROS↓, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis ⓘ

LDHA↑, 1,  

Cell Death ⓘ

Cyt‑c↓, 1,   IAP1↓, 1,  

Protein Folding & ER Stress ⓘ

HSP27↓, 1,  

Autophagy & Lysosomes ⓘ

Beclin-1↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,  

Functional Outcomes ⓘ

neuroP↑, 1,   toxicity↓, 1,  
Total Targets: 11

Scientific Paper Hit Count for: BID, BH3 interacting-domain death agonist
4 Baicalein
4 Phenethyl isothiocyanate
2 Sulforaphane (mainly Broccoli)
2 Silver-NanoParticles
1 Apigenin (mainly Parsley)
1 Boron
1 Caffeic acid
1 Chrysin
1 Curcumin
1 Docetaxel
1 EGCG (Epigallocatechin Gallate)
1 Fucoidan
1 Fisetin
1 Luteolin
1 Phenylbutyrate
1 Silymarin (Milk Thistle) silibinin
1 Camptothecin
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:466  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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