Database Query Results : , , NHE1

NHE1, Na+/H+ exchanger isoform 1: Click to Expand ⟱
Source:
Type:
Plays a crucial role in cancer cell proliferation and metastasis.
NHE1 is a ubiquitously expressed acid-extruding membrane transport protein, and upregulation of its expression and/or activity is commonly correlated with tumor malignancy.
Scientific Papers found: Click to Expand⟱
1612- EA,    Negative Effect of Ellagic Acid on Cytosolic pH Regulation and Glycolytic Flux in Human Endometrial Cancer Cell
- in-vitro, EC, NA
NHE1↓, i-pH↓, ROS↓, GlucoseCon↓, NHE1↓, Glycolysis↓,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1?, PDK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
946- Nimb,    Nimbolide retards T cell lymphoma progression by altering apoptosis, glucose metabolism, pH regulation, and ROS homeostasis
- in-vivo, NA, NA
Apoptosis↑, Bcl-2↓, P53↑, cl‑Casp3↑, Cyt‑c↑, ROS↑, SOD↓, Catalase↓, Glycolysis↓, GLUT3↓, LDHA↓, MCT1↓, NHE1↓, ATPase↓, CAIX↓,
76- QC,    Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy
- in-vitro, Pca, PC3
aSmase↝, Diablo↝, Fas↝, Hsc70↝, Hif1a↝, Mcl-1↝, HSP90↝, FLT4↝, EphB4↝, DNA-PK↝, PARP1↝, ATM↝, XIAP↝, PLC↝, GnT-V↝, heparanase↝, NM23↝, CSR1↝, SPP1↝, DNMT1↝, HDAC4↝, CXCR4↝, β-catenin/ZEB1↝, FBXW7↝, AMACR↝, cycD1/CCND1↝, IGF-1R↝, IMPDH1↝, IMPDH2↝, HEC1↝, NHE1↝, NOS2↝,
3282- SIL,    Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions
- Review, NA, NA
hepatoP↑, AntiCan↑, TumCMig↓, Hif1a↓, selectivity↑, toxicity∅, *antiOx↑, *Inflam↓, TumCCA↑, P21↑, CDK4↓, NF-kB↓, ERK↓, PSA↓, TumCG↓, p27↑, COX2↓, IL1↓, VEGF↓, IGFBP3↑, AR↓, STAT3↓, Telomerase↓, Cyt‑c↑, Casp↑, eff↝, HDAC↓, HATs↑, Zeb1↓, E-cadherin↑, miR-203↑, NHE1↓, MMP2↓, MMP9↓, PGE2↓, Vim↓, Wnt↓, angioG↓, VEGF↓, *TIMP1↓, EMT↓, TGF-β↓, CD44↓, EGFR↓, PDGF↓, *IL8↓, SREBP1↓, MMP↓, ATP↓, uPA↓, PD-L1↓, NOTCH↓, *SIRT1↑, SIRT1↓, CA↓, Ca+2↑, chemoP↑, cardioP↑, Dose↝, Half-Life↝, BioAv↓, BioAv↓, BioAv↓, toxicity↝, Half-Life↓, ROS↓, FAK↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↓, 1,   Catalase↓, 1,   HO-1↓, 1,   HO-2↓, 1,   ROS↓, 2,   ROS↑, 2,   SOD↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   ATP↓, 1,   MMP↓, 2,   XIAP↓, 1,   XIAP↝, 1,  

Core Metabolism/Glycolysis ⓘ

AMACR↝, 1,   CAIX↓, 1,   cMyc↓, 1,   ECAR↝, 1,   GlucoseCon↓, 2,   Glycolysis↓, 3,   lactateProd↓, 1,   LDHA↓, 1,   PDK1?, 2,   SIRT1↓, 2,   SREBP1↓, 1,  

Cell Death ⓘ

Akt↑, 1,   p‑Akt↓, 1,   Apoptosis↑, 1,   aSmase↝, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,   Casp↑, 1,   Casp3↑, 1,   cl‑Casp3↑, 1,   Casp9↑, 1,   CSR1↝, 1,   Cyt‑c↑, 3,   Diablo↑, 1,   Diablo↝, 1,   Fas↝, 1,   iNOS↓, 1,   Mcl-1↓, 1,   Mcl-1↝, 1,   MCT1↓, 1,   MDM2↓, 1,   Myc↓, 1,   NOXA↑, 1,   p27↑, 1,   PUMA↑, 1,   survivin↓, 1,   Telomerase↓, 2,  

Transcription & Epigenetics ⓘ

HATs↑, 1,   SPP1↝, 1,   tumCV↓, 1,  

Protein Folding & ER Stress ⓘ

Hsc70↝, 1,   HSP90↝, 1,  

DNA Damage & Repair ⓘ

ATM↝, 1,   DNA-PK↝, 1,   DNAdam↓, 1,   DNMT1↝, 1,   P53↑, 2,   cl‑PARP↑, 1,   PARP1↝, 1,   SIRT6↑, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycD1/CCND1↝, 1,   cycE/CCNE↓, 1,   P21↑, 2,   p‑RB1↓, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

CD44↓, 1,   CDK8↓, 1,   EMT↓, 1,   ERK↓, 1,   p‑ERK↓, 1,   FBXW7↝, 1,   HDAC↓, 1,   HDAC4↝, 1,   IGF-1R↝, 1,   IGFBP3↑, 1,   NOTCH↓, 2,   PTEN↑, 1,   STAT3↓, 2,   p‑STAT3↓, 1,   TumCG↓, 1,   Wnt↓, 1,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

ATPase↓, 1,   CA↓, 1,   Ca+2↑, 1,   Ca+2↝, 1,   E-cadherin↑, 1,   EphB4↝, 1,   FAK↓, 1,   p‑FAK↓, 1,   GnT-V↝, 1,   heparanase↝, 1,   miR-203↑, 1,   MMP2↓, 2,   MMP9↓, 2,   NM23↝, 1,   PDGF↓, 1,   PKCδ↓, 1,   SMAD3↓, 1,   Snail↓, 1,   TGF-β↓, 2,   TumCMig↓, 1,   TumCP↓, 1,   Twist↓, 1,   uPA↓, 1,   Vim↓, 1,   Zeb1↓, 1,   β-catenin/ZEB1↝, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 2,   EGFR↓, 2,   Endoglin↑, 1,   FLT4↝, 1,   Hif1a↓, 2,   Hif1a↝, 1,   VEGF↓, 3,  

Barriers & Transport ⓘ

GLUT3↓, 1,   NHE1↓, 5,   NHE1↝, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 1,   COX2↓, 2,   CXCR4↝, 1,   IL1↓, 1,   Inflam↓, 1,   JAK↓, 1,   NF-kB↓, 2,   PD-L1↓, 2,   PGE2↓, 1,   PSA↓, 1,  

Cellular Microenvironment ⓘ

i-pH↓, 1,   PLC↝, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 2,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 3,   Dose↝, 2,   Dose∅, 1,   eff↑, 2,   eff↝, 1,   Half-Life↓, 1,   Half-Life↝, 1,   RadioS↑, 2,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

AR↓, 1,   EGFR↓, 2,   HEC1↝, 1,   Myc↓, 1,   NOS2↝, 1,   PD-L1↓, 2,   PSA↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   cardioP↑, 1,   chemoP↑, 1,   hepatoP↑, 1,   IMPDH1↝, 1,   IMPDH2↝, 1,   toxicity↝, 1,   toxicity∅, 1,  
Total Targets: 162

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,  

Core Metabolism/Glycolysis ⓘ

SIRT1↑, 1,  

Migration ⓘ

TIMP1↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL8↓, 1,   Inflam↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,  
Total Targets: 6

Scientific Paper Hit Count for: NHE1, Na+/H+ exchanger isoform 1
2 Ellagic acid
1 Nimbolide
1 Quercetin
1 Silymarin (Milk Thistle) silibinin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:474  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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