Database Query Results : , , p44

p44, p44/ERK1: Click to Expand ⟱
Source:
Type:
The P44 protein, also known as p44 or p44/ERK1, is a member of the mitogen-activated protein kinase (MAPK) family, specifically the extracellular signal-regulated kinases (ERKs). These proteins play a crucial role in various cellular processes, including proliferation, differentiation, and survival, and are involved in signaling pathways that can influence cancer development and progression

p44 tends to be overexpressed in several hormone–driven and other cancers, correlating with more aggressive disease and poorer prognosis, thereby acting in a protumorigenic manner.
Scientific Papers found: Click to Expand⟱
424- CUR,    Curcumin inhibits autocrine growth hormone-mediated invasion and metastasis by targeting NF-κB signaling and polyamine metabolism in breast cancer cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
Src↓, p‑STAT1↓, p‑Akt↓, p‑p44↓, p‑p42↓, RAS↓, Raf↓, Vim↓, β-catenin/ZEB1↓, P53↓, Bcl-2↓, Mcl-1↓, PIAS-3↑, SOCS-3↑, SOCS1↑, ROS↑, NF-kB↓, PAO↑, SSAT↑, P21↑, Bak↑,
87- QC,    Quercetin inhibits prostate cancer by attenuating cell survival and inhibiting anti-apoptotic pathways
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3
ROS⇅, BAX↑, PUMA⇅, β-catenin/ZEB1↓, Shc↓, TAp63α↑, MAPK↑, p‑p42↑, p‑p44↑, BIM↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

PAO↑, 1,   ROS↑, 1,   ROS⇅, 1,  

Mitochondria & Bioenergetics ⓘ

p‑p42↓, 1,   p‑p42↑, 1,   Raf↓, 1,  

Core Metabolism/Glycolysis ⓘ

SSAT↑, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   Bak↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   BIM↑, 1,   MAPK↑, 1,   Mcl-1↓, 1,   PUMA⇅, 1,  

Transcription & Epigenetics ⓘ

Shc↓, 1,  

DNA Damage & Repair ⓘ

P53↓, 1,  

Cell Cycle & Senescence ⓘ

P21↑, 1,   TAp63α↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

PIAS-3↑, 1,   RAS↓, 1,   Src↓, 1,   p‑STAT1↓, 1,  

Migration ⓘ

p‑p44↓, 1,   p‑p44↑, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 2,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,   SOCS-3↑, 1,   SOCS1↑, 1,  
Total Targets: 30

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: p44, p44/ERK1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:482  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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