Database Query Results : , , MALAT1

MALAT1, Metastasis Associated Lung Adenocarcinoma Transcript 1: Click to Expand ⟱
Source:
Type:
MALAT1 (Metastasis Associated Lung Adenocarcinoma Transcript 1) is a long non-coding RNA (lncRNA) that has been implicated in various types of cancer, including lung cancer, breast cancer, and colorectal cancer.
MALAT1 is often overexpressed in cancer tissues compared to normal tissues. Its expression levels have been correlated with tumor progression, metastasis, and poor prognosis in several cancers. It has been shown to promote the metastatic potential of cancer cells by regulating epithelial-mesenchymal transition (EMT) and enhancing cell migration and invasion.
Scientific Papers found: Click to Expand⟱
2648- AL,    Allicin Inhibits Osteosarcoma Growth by Promoting Oxidative Stress and Autophagy via the Inactivation of the lncRNA MALAT1-miR-376a-Wnt/β-Catenin Signaling Pathway
- in-vitro, OS, SaOS2 - in-vivo, OS, NA
ROS↑, TumCG↓, TumAuto↑, Wnt↓, β-catenin/ZEB1↓, MALAT1↓,
2666- AL,    Targeting the Interplay of Autophagy and ROS for Cancer Therapy: An Updated Overview on Phytochemicals
- Review, Var, NA
Inflam↓, AntiCan↑, ROS↑, MAPK↑, JNK↑, TumAuto↑, other↑, Dose↝, MALAT1↓, Wnt↓, β-catenin/ZEB1↓,
2729- BetA,    Betulinic acid in the treatment of tumour diseases: Application and research progress
- Review, Var, NA
ChemoSen↑, mt-ROS↑, STAT3↓, NF-kB↓, selectivity↑, *toxicity↓, eff↑, GRP78/BiP↑, MMP2↓, P90RSK↓, TumCI↓, EMT↓, MALAT1↓, Glycolysis↓, AMPK↑, Sp1/3/4↓, Hif1a↓, angioG↓, NF-kB↑, NF-kB↓, MMP↓, Cyt‑c↑, Casp9↑, Casp3↑, RadioS↑, PERK↑, CHOP↑, *toxicity↓,
1673- PBG,    An Insight into Anticancer Effect of Propolis and Its Constituents: A Review of Molecular Mechanisms
- Review, Var, NA
TumCP↓, Apoptosis↑, TumCCA↑, MALAT1↓, P53↑, RadioS↑, OS↑, ROS↑, NF-kB↓, p65↑, MMP↓, ROS↑, MMP9↓, β-catenin/ZEB1↓, Vim↓, E-cadherin↓, VEGF↓, EMT↓,
99- QC,    Quercetin Inhibits Epithelial-to-Mesenchymal Transition (EMT) Process and Promotes Apoptosis in Prostate Cancer via Downregulating lncRNA MALAT1
- in-vitro, Pca, PC3
EMT↓, E-cadherin↑, N-cadherin↓, Ki-67↓, PI3K/Akt↓, MALAT1↓,
877- RES,    Resveratrol Inhibits Invasion and Metastasis of Colorectal Cancer Cells via MALAT1 Mediated Wnt/β-Catenin Signal Pathway
- in-vitro, CRC, LoVo - in-vitro, CRC, HCT116
MALAT1↓, Wnt/(β-catenin)↓, TumCI↓, TumMeta↓,
1489- RES,    Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer
- Review, Var, NA
RadioS↑, ChemoSen↑, *BioAv↓, *BioAv↑, Ferroptosis↑, lipid-P↑, xCT↓, GPx4↓, *BioAv↑, COX2↓, cycD1/CCND1↓, FasL↓, FOXP3↓, HLA↑, p‑NF-kB↓, BAX↑, Bcl-2↓, MALAT1↓,
2687- RES,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, NA, NA - Review, AD, NA
NF-kB↓, P450↓, COX2↓, Hif1a↓, VEGF↓, *SIRT1↑, SIRT1↓, SIRT2↓, ChemoSen⇅, cardioP↑, *memory↑, *angioG↑, *neuroP↑, STAT3↓, CSCs↓, RadioS↑, Nestin↓, Nanog↓, TP53↑, P21↑, CXCR4↓, *BioAv↓, EMT↓, Vim↓, Slug↓, E-cadherin↑, AMPK↑, MDR1↓, DNAdam↑, TOP2↓, PTEN↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, cMyc↓, MMP7↓, MALAT1↓, TCF↓, ALDH↓, CD44↓, Shh↓, IL6↓, VEGF↓, eff↑, HK2↓, ROS↑, MMP↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,   GPx4↓, 1,   lipid-P↑, 1,   ROS↑, 5,   mt-ROS↑, 1,   xCT↓, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 3,  

Core Metabolism/Glycolysis ⓘ

AMPK↑, 2,   cMyc↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   PI3K/Akt↓, 1,   SIRT1↓, 1,   SIRT2↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   FasL↓, 1,   Ferroptosis↑, 1,   JNK↑, 1,   MAPK↑, 1,  

Kinase & Signal Transduction ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   GRP78/BiP↑, 1,   PERK↑, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 2,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   P53↑, 1,   TP53↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

ALDH↓, 1,   CD44↓, 1,   CSCs↓, 1,   EMT↓, 4,   Nanog↓, 1,   Nestin↓, 1,   P90RSK↓, 1,   PTEN↑, 1,   Shh↓, 1,   STAT3↓, 2,   TCF↓, 1,   TOP2↓, 1,   TumCG↓, 1,   Wnt↓, 3,   Wnt/(β-catenin)↓, 1,  

Migration ⓘ

E-cadherin↓, 1,   E-cadherin↑, 2,   HLA↑, 1,   Ki-67↓, 1,   MALAT1↓, 8,   MMP2↓, 1,   MMP7↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   Slug↓, 1,   TumCI↓, 2,   TumCP↓, 1,   TumMeta↓, 1,   Vim↓, 2,   β-catenin/ZEB1↓, 4,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   Hif1a↓, 2,   VEGF↓, 3,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 2,   CXCR4↓, 1,   FOXP3↓, 1,   IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 4,   NF-kB↑, 1,   p‑NF-kB↓, 1,   p65↑, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 2,   ChemoSen⇅, 1,   Dose↝, 1,   eff↑, 2,   MDR1↓, 1,   P450↓, 1,   RadioS↑, 4,   selectivity↑, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,   Ki-67↓, 1,   TP53↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   cardioP↑, 1,   OS↑, 1,  
Total Targets: 93

Pathway results for Effect on Normal Cells:


Core Metabolism/Glycolysis ⓘ

SIRT1↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 2,  

Functional Outcomes ⓘ

memory↑, 1,   neuroP↑, 1,   toxicity↓, 2,  
Total Targets: 7

Scientific Paper Hit Count for: MALAT1, Metastasis Associated Lung Adenocarcinoma Transcript 1
3 Resveratrol
2 Allicin (mainly Garlic)
1 Betulinic acid
1 Propolis -bee glue
1 Quercetin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:493  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page