Database Query Results : , , CDKN1C

CDKN1C, cyclin-dependent kinase (CDK) inhibitors of the Cip/Kip family: Click to Expand ⟱
Source:
Type:
CDKN1C(p57 KIP2)
CDKN1C, also known as p57^KIP2, is a cyclin-dependent kinase inhibitor that plays a role in regulating the cell cycle.
Decreased expression of CDKN1C is often associated with more aggressive tumor behavior, increased invasiveness, and poorer prognosis across various cancer types.
Scientific Papers found: Click to Expand⟱
2784- CHr,    Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)
- Review, Var, NA
Apoptosis↑, TumCMig↓, *toxicity↝, ChemoSen↑, *BioAv↓, Dose↝, neuroP↑, *P450↓, *ROS↓, *HDL↑, *GSTs↑, *SOD↑, *Catalase↑, *MAPK↓, *NF-kB↓, *PTEN↑, *VEGF↑, ROS↑, MMP↓, Ca+2↑, selectivity↑, PCNA↓, Twist↓, EMT↓, CDKN1C↑, p‑STAT3↑, MMP2↓, MMP9↓, eff↑, cycD1/CCND1↓, hTERT/TERT↓, CLDN1↓, TumVol↓, OS↑, COX2↓, eff↑, CDK2↓, CDK4↓, selectivity↑, TumCCA↑, E-cadherin↑, HK2↓, HDAC↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis ⓘ

HK2↓, 1,  

Cell Death ⓘ

Apoptosis↑, 1,   hTERT/TERT↓, 1,  

DNA Damage & Repair ⓘ

PCNA↓, 1,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 1,   HDAC↓, 1,   p‑STAT3↑, 1,  

Migration ⓘ

Ca+2↑, 1,   CDKN1C↑, 1,   CLDN1↓, 1,   E-cadherin↑, 1,   MMP2↓, 1,   MMP9↓, 1,   TumCMig↓, 1,   Twist↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   Dose↝, 1,   eff↑, 2,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

hTERT/TERT↓, 1,  

Functional Outcomes ⓘ

neuroP↑, 1,   OS↑, 1,   TumVol↓, 1,  
Total Targets: 30

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   GSTs↑, 1,   HDL↑, 1,   ROS↓, 1,   SOD↑, 1,  

Cell Death ⓘ

MAPK↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

PTEN↑, 1,  

Angiogenesis & Vasculature ⓘ

VEGF↑, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 1,   P450↓, 1,  

Functional Outcomes ⓘ

toxicity↝, 1,  
Total Targets: 12

Scientific Paper Hit Count for: CDKN1C, cyclin-dependent kinase (CDK) inhibitors of the Cip/Kip family
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:496  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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