Database Query Results : , , ACTA2

ACTA2, Actin Alpha Cardiac Muscle 2: Click to Expand ⟱
Source:
Type:
ACTA2 (Actin Alpha Cardiac Muscle 2) is a gene that encodes a protein involved in the structure and function of smooth muscle cells. It plays a crucial role in various physiological processes, iACTA2 has been studied for its role in the tumor microenvironment, particularly in relation to cancer-associated fibroblasts (CAFs) and the extracellular matrix. CAFs, which often express ACTA2, can influence tumor progression, metastasis, and response to therapy. ncluding muscle contraction and the maintenance of vascular tone.
High levels of ACTA2 are often correlated with aggressive tumor behavior and poor patient outcomes.
Scientific Papers found: Click to Expand⟱
3228- EGCG,    Targeting fibrotic signaling pathways by EGCG as a therapeutic strategy for uterine fibroids
*cycD1/CCND1↓, *COL1A1↓, *ACTA2↓, *α-SMA↓,
105- RES,  QC,    The Effect of Resveratrol and Quercetin on Epithelial-Mesenchymal Transition in Pancreatic Cancer Stem Cell
- in-vitro, Pca, CD133+
N-cadherin↓, TNF-α↓, ACTA2↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Migration ⓘ

ACTA2↓, 1,   N-cadherin↓, 1,  

Immune & Inflammatory Signaling ⓘ

TNF-α↓, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Migration ⓘ

ACTA2↓, 1,   COL1A1↓, 1,   α-SMA↓, 1,  
Total Targets: 4

Scientific Paper Hit Count for: ACTA2, Actin Alpha Cardiac Muscle 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:507  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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