Database Query Results : , , IP-10/CXCL-10

IP-10/CXCL-10, Interferon-γ(IFN)-inducible protein 10: Click to Expand ⟱
Source:
Type:
Interferon-γ-inducible protein 10 (IP-10), also known as CXCL10, is a chemokine that plays a significant role in immune responses, particularly in the recruitment of immune cells to sites of inflammation and infection. Its expression has been studied in various cancers, and it has implications for tumor behavior and the immune response.
Interferon-γ-inducible protein 10 is a potent chemoattractant for natural killer cells and activated T lymphocytes. It also displays angiostatic properties and some antitumor activity.
IP-10 upregulation correlated with shorter survival provides evidence that IP-10 plays a functional role in pancreatic cancer.
Interferon-γ-inducible protein 10 (IP-10) is a potent inhibitor of tumor angiogenesis. It has been reported that the antiangiogenic therapy combined with chemotherapy has synergistic effects.

Mixed Prognosis: The prognostic implications of IP-10 in cancer can vary. In some cases, high levels of IP-10 may correlate with a favorable immune response and better prognosis, while in other contexts, it may be associated with tumor progression and poor outcomes.
Scientific Papers found: Click to Expand⟱
190- MFrot,  MF,    The efficacy and safety of low-frequency rotating static magnetic field therapy combined with chemotherapy on advanced lung cancer patients: a randomized, double-blinded, controlled clinical trial
- Human, Lung, NA
*IP-10/CXCL-10↑, *GM-CSF↑, *TREM-1↓,
1432- SFN,    Evaluation of biodistribution of sulforaphane after administration of oral broccoli sprout extract in melanoma patients with multiple atypical nevi
- Human, Melanoma, NA
other↑, decorin↑, *toxicity↓, IP-10/CXCL-10↓, MCP1↓, CXCL9↓, MIP-1β↓, IFN-γ↓,
3404- TQ,    The Neuroprotective Effects of Thymoquinone: A Review
- Review, Var, NA - Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *TNF-α↓, *IL6↓, *IL1β↓, *NF-kB↓, *iNOS↓, *NRF2↑, *neuroP↑, *MMP↑, *ROS↓, *MDA↓, *GSH↑, *Catalase↑, *SOD↑, *IL12↓, *MCP1↓, *IP-10/CXCL-10↓, *PGE2↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Transcription & Epigenetics ⓘ

other↑, 1,  

Migration ⓘ

decorin↑, 1,  

Immune & Inflammatory Signaling ⓘ

CXCL9↓, 1,   IFN-γ↓, 1,   IP-10/CXCL-10↓, 1,   MCP1↓, 1,   MIP-1β↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

Catalase↑, 1,   GSH↑, 1,   MDA↓, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↑, 1,  

Cell Death ⓘ

iNOS↓, 1,  

Transcription & Epigenetics ⓘ

TREM-1↓, 1,  

Immune & Inflammatory Signaling ⓘ

GM-CSF↑, 1,   IL12↓, 1,   IL1β↓, 1,   IL6↓, 1,   Inflam↓, 1,   IP-10/CXCL-10↓, 1,   IP-10/CXCL-10↑, 1,   MCP1↓, 1,   NF-kB↓, 1,   PGE2↓, 1,   TNF-α↓, 1,  

Clinical Biomarkers ⓘ

IL6↓, 1,  

Functional Outcomes ⓘ

neuroP↑, 1,   toxicity↓, 1,  
Total Targets: 23

Scientific Paper Hit Count for: IP-10/CXCL-10, Interferon-γ(IFN)-inducible protein 10
1 Magnetic Field Rotating
1 Magnetic Fields
1 Sulforaphane (mainly Broccoli)
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:534  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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