Database Query Results : , , CCDC150

CCDC150, CCDC150, Coiled-coil domain-containing (CCDC) proteins: Click to Expand ⟱
Source:
Type:
Coiled-coil domain-containing (CCDC) proteins constitute a class of homo-oligomeric or oligomeric sequence proteins containing two or more coiled-coil structural domains, crucial for the assembly and arrangement of the cytoskeleton.
CCDC150 is a prognostic marker in Kidney renal clear cell carcinoma, Pancreatic adenocarcinoma Cancer.
CCDC150, which exhibited abnormal expression in TNBC and responded to gradient RMF. CCDCs participate in the formation of backbone proteins and the polymerization of actin, which is pivotal in driving the epithelial–mesenchymal transition of tumor cells. Abnormal up-regulation of some CCDCs is found in tumors, and they are positively correlated with tumor metastasis. For instance, CCDC6 exhibits aberrantly high expression in thyroid cancer, and CCDC66 is significantly up-regulated in colorectal cancer to promote tumor invasion and metastasis. We found that the expression of CCDC150 in TNBC was significantly increased.
Scientific Papers found: Click to Expand⟱
201- MFrot,  MF,    Gradient Rotating Magnetic Fields Impairing F-Actin-Related Gene CCDC150 to Inhibit Triple-Negative Breast Cancer Metastasis by Inactivating TGF-β1/SMAD3 Signaling Pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549 - in-vitro, BC, MDA-MB-468
CCDC150↓, TGF-β↓, SMAD3↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Migration ⓘ

CCDC150↓, 1,   SMAD3↓, 1,   TGF-β↓, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CCDC150, CCDC150, Coiled-coil domain-containing (CCDC) proteins
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:555  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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