Database Query Results : , , AhR

AhR, aryl hydrocarbon receptor: Click to Expand ⟱
Source:
Type:
AhR is a ligand-activated transcription factor that plays a crucial role in regulating various cellular processes, including cell growth, differentiation, and immune responses.
AhR is overexpressed in lung cancer cells and is associated with poor prognosis.
-Cell proliferation: AhR activation promotes cell growth and proliferation.
-Apoptosis: AhR activation inhibits apoptosis (programmed cell death), allowing cancer cells to survive.
-Angiogenesis: AhR activation promotes the formation of new blood vessels, which is essential for tumor growth.
-Immune suppression: AhR activation inhibits the immune response, allowing cancer cells to evade immune detection.
AhR regulates expression of CYP1A1, CYP1B1, and COX-2
AhR is often overexpressed in various types of cancer, including breast, lung, liver, and skin cancer. AhR expression is often higher in tumor cells compared to normal cells.
Scientific Papers found: Click to Expand⟱
232- AL,    A Single Meal Containing Raw, Crushed Garlic Influences Expression of Immunity- and Cancer-Related Genes in Whole Blood of Humans
- Human, Nor, NA
*AhR↑, *ARNT↑, *Hif1a↑, *Jun↑, *NFAT↑, *NFAM1↑, *REL↑, *OSM↑, *NFAT↑, *CXCc↑, *IL2↑, *IL6↑, *LIF↑,
3061- RES,    The Anticancer Effects of Resveratrol: Modulation of Transcription Factors
- Review, Var, NA
AhR↓, NRF2↑, *NQO1↑, *HO-1↑, *GSH↑, P53↑, Cyt‑c↑, Diablo↑, Bcl-2↓, Bcl-xL↓, survivin↓, XIAP↓, FOXO↑, p‑PI3K↓, p‑Akt↓, BIM↑, DR4↑, DR5↑, p27↑, cycD1/CCND1↓, SIRT1↑, NF-kB↓, ATF3↑,
3312- SIL,    Silymarin Alleviates Oxidative Stress and Inflammation Induced by UV and Air Pollution in Human Epidermis and Activates β-Endorphin Release through Cannabinoid Receptor Type 2
- Human, Nor, NA
*antiOx↑, *Inflam↓, *ROS↓, *IL1α↓, *AhR↑, *NRF2↑, *IL8↓,
2216- SK,    Shikonin upregulates the expression of drug-metabolizing enzymes and drug transporters in primary rat hepatocytes
- in-vivo, Nor, NA
*NRF2↑, *AhR↑, *CYP1A1↑, *CYP1A2↑, *CYP2C6↑, *CYP2D1↑, *CYP3A2↑, *NQO1↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ATF3↑, 1,   NRF2↑, 1,  

Mitochondria & Bioenergetics ⓘ

XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

SIRT1↑, 1,  

Cell Death ⓘ

AhR↓, 1,   p‑Akt↓, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,   BIM↑, 1,   Cyt‑c↑, 1,   Diablo↑, 1,   DR4↑, 1,   DR5↑, 1,   p27↑, 1,   survivin↓, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

FOXO↑, 1,   p‑PI3K↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 1,  
Total Targets: 20

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   CYP1A1↑, 1,   GSH↑, 1,   HO-1↑, 1,   NQO1↑, 2,   NRF2↑, 2,   ROS↓, 1,  

Core Metabolism/Glycolysis ⓘ

CYP2C6↑, 1,   CYP3A2↑, 1,  

Cell Death ⓘ

AhR↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

Jun↑, 1,  

Migration ⓘ

CYP2D1↑, 1,   NFAM1↑, 1,   NFAT↑, 2,  

Angiogenesis & Vasculature ⓘ

Hif1a↑, 1,   REL↑, 1,  

Immune & Inflammatory Signaling ⓘ

CXCc↑, 1,   IL1α↓, 1,   IL2↑, 1,   IL6↑, 1,   IL8↓, 1,   Inflam↓, 1,   LIF↑, 1,   OSM↑, 1,  

Hormonal & Nuclear Receptors ⓘ

ARNT↑, 1,  

Drug Metabolism & Resistance ⓘ

CYP1A2↑, 1,  

Clinical Biomarkers ⓘ

IL6↑, 1,  
Total Targets: 27

Scientific Paper Hit Count for: AhR, aryl hydrocarbon receptor
1 Allicin (mainly Garlic)
1 Resveratrol
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:584  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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