Database Query Results : , , REL

REL, V-rel avian reticuloendotheliosis viral oncogene homolog (REL): Click to Expand ⟱
Source:
Type:
REL, is a protein that plays a crucial role in the regulation of cell growth, differentiation, and survival. REL is a member of the NF-κB family of transcription factors, which are involved in various cellular processes, including immune responses, inflammation, and cell proliferation.
REL has been implicated in the development and progression of various types of cancer, including lymphomas, leukemias, and solid tumors. The protein is often constitutively active in cancer cells, leading to the activation of genes involved in cell proliferation, survival, and angiogenesis.
Studies have shown that REL is overexpressed in several types of cancer.
REL can also interact with other transcription factors, such as p50 and p65, to form heterodimers that regulate gene expression.
-Activation of cell cycle progression: REL can activate genes involved in cell cycle progression, leading to increased cell proliferation.
-Inhibition of apoptosis: REL can inhibit apoptosis by activating anti-apoptotic genes and repressing pro-apoptotic genes.
-Promotion of angiogenesis: REL can activate genes involved in angiogenesis, leading to increased blood vessel formation and tumor growth.
-Modulation of immune responses: REL can modulate immune responses by regulating the expression of genes involved in inflammation and immune cell activation.
Scientific Papers found: Click to Expand⟱
232- AL,    A Single Meal Containing Raw, Crushed Garlic Influences Expression of Immunity- and Cancer-Related Genes in Whole Blood of Humans
- Human, Nor, NA
*AhR↑, *ARNT↑, *Hif1a↑, *Jun↑, *NFAT↑, *NFAM1↑, *REL↑, *OSM↑, *NFAT↑, *CXCc↑, *IL2↑, *IL6↑, *LIF↑,
414- CUR,    Transcriptome Investigation and In Vitro Verification of Curcumin-Induced HO-1 as a Feature of Ferroptosis in Breast Cancer Cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
Ferroptosis↑, Iron↑, ROS↑, lipid-P↑, MDA↑, GSH↓, HO-1↑, NRF2↑, GPx↓, ROS↑, Iron↑, GPx4↓, HSP70/HSPA5↑, ATFs↑, CHOP↑, MDA↑, FTL↑, FTH1↑, BACH1↑, REL↑, USF1↑, NFE2L2↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Ferroptosis↑, 1,   GPx↓, 1,   GPx4↓, 1,   GSH↓, 1,   HO-1↑, 1,   Iron↑, 2,   lipid-P↑, 1,   MDA↑, 2,   NFE2L2↑, 1,   NRF2↑, 1,   ROS↑, 2,  

Metal & Cofactor Biology ⓘ

FTH1↑, 1,   FTL↑, 1,  

Cell Death ⓘ

Ferroptosis↑, 1,  

Transcription & Epigenetics ⓘ

USF1↑, 1,  

Protein Folding & ER Stress ⓘ

ATFs↑, 1,   CHOP↑, 1,   HSP70/HSPA5↑, 1,  

Migration ⓘ

BACH1↑, 1,  

Angiogenesis & Vasculature ⓘ

REL↑, 1,  
Total Targets: 20

Pathway results for Effect on Normal Cells:


Cell Death ⓘ

AhR↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Jun↑, 1,  

Migration ⓘ

NFAM1↑, 1,   NFAT↑, 2,  

Angiogenesis & Vasculature ⓘ

Hif1a↑, 1,   REL↑, 1,  

Immune & Inflammatory Signaling ⓘ

CXCc↑, 1,   IL2↑, 1,   IL6↑, 1,   LIF↑, 1,   OSM↑, 1,  

Hormonal & Nuclear Receptors ⓘ

ARNT↑, 1,  

Clinical Biomarkers ⓘ

IL6↑, 1,  
Total Targets: 13

Scientific Paper Hit Count for: REL, V-rel avian reticuloendotheliosis viral oncogene homolog (REL)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:588  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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