Database Query Results : , , OSM

OSM, oncostatin: Click to Expand ⟱
Source:
Type:
OSM is a protein that belongs to the interleukin-6 (IL-6) family of cytokines.

OSM has been shown to have both tumor-promoting and tumor-suppressing effects, depending on the type of cancer and the context in which it is expressed.
Tumor-promoting effects:
    Angiogenesis: OSM can stimulate the formation of new blood vessels, which is essential for tumor growth and metastasis.
    Cell proliferation: OSM can promote the proliferation of cancer cells, particularly in breast, lung, and colon cancers.
    Inflammation: OSM can induce the production of pro-inflammatory cytokines, which can create a tumor-friendly microenvironment.

Tumor-suppressing effects:
    Apoptosis: OSM can induce apoptosis (programmed cell death) in certain types of cancer cells, such as melanoma and leukemia.
    Anti-angiogenesis: OSM can also inhibit the formation of new blood vessels, which can limit tumor growth.
    Immune response: OSM can stimulate the immune system to attack cancer cells, particularly in the context of immunotherapy.
Scientific Papers found: Click to Expand⟱
232- AL,    A Single Meal Containing Raw, Crushed Garlic Influences Expression of Immunity- and Cancer-Related Genes in Whole Blood of Humans
- Human, Nor, NA
*AhR↑, *ARNT↑, *Hif1a↑, *Jun↑, *NFAT↑, *NFAM1↑, *REL↑, *OSM↑, *NFAT↑, *CXCc↑, *IL2↑, *IL6↑, *LIF↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Cell Death ⓘ

AhR↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Jun↑, 1,  

Migration ⓘ

NFAM1↑, 1,   NFAT↑, 2,  

Angiogenesis & Vasculature ⓘ

Hif1a↑, 1,   REL↑, 1,  

Immune & Inflammatory Signaling ⓘ

CXCc↑, 1,   IL2↑, 1,   IL6↑, 1,   LIF↑, 1,   OSM↑, 1,  

Hormonal & Nuclear Receptors ⓘ

ARNT↑, 1,  

Clinical Biomarkers ⓘ

IL6↑, 1,  
Total Targets: 13

Scientific Paper Hit Count for: OSM, oncostatin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:589  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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