Database Query Results : , , LIF

LIF, leukemia inhibitory factor: Click to Expand ⟱
Source:
Type:
(LIF) is a type of protein that plays a crucial role in various cellular processes, including cell growth, differentiation, and survival. It is a member of the interleukin-6 (IL-6) family of cytokines and is involved in the regulation of the immune system, inflammation, and hematopoiesis (the formation of blood cells).
LIF has been shown to promote tumor growth and metastasis, and to contribute to the development of cancer stem cells. Inhibiting LIF signaling may provide a novel approach to cancer therapy.
(LIF) is expressed in various types of cancer, and its expression has been associated with tumor progression, metastasis, and poor prognosis. (Ovarian, Leukemia, Melanoma, Glioblastoma, Colorectal, Prostrate).
Scientific Papers found: Click to Expand⟱
232- AL,    A Single Meal Containing Raw, Crushed Garlic Influences Expression of Immunity- and Cancer-Related Genes in Whole Blood of Humans
- Human, Nor, NA
*AhR↑, *ARNT↑, *Hif1a↑, *Jun↑, *NFAT↑, *NFAM1↑, *REL↑, *OSM↑, *NFAT↑, *CXCc↑, *IL2↑, *IL6↑, *LIF↑,
3478- MF,    One Month of Brief Weekly Magnetic Field Therapy Enhances the Anticancer Potential of Female Human Sera: Randomized Double-Blind Pilot Study
- Trial, BC, NA - in-vitro, BC, MCF-7 - in-vitro, Nor, C2C12
TumCP↓, TumCMig↓, TumCI↓, *toxicity∅, TGF-β↓, Twist↓, Slug↓, β-catenin/ZEB1↓, Vim↓, p‑SMAD2↓, p‑SMAD3↓, angioG↓, VEGF↓, selectivity↑, LIF↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Migration ⓘ

Slug↓, 1,   p‑SMAD2↓, 1,   p‑SMAD3↓, 1,   TGF-β↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   Twist↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling ⓘ

LIF↑, 1,  

Drug Metabolism & Resistance ⓘ

selectivity↑, 1,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Cell Death ⓘ

AhR↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

Jun↑, 1,  

Migration ⓘ

NFAM1↑, 1,   NFAT↑, 2,  

Angiogenesis & Vasculature ⓘ

Hif1a↑, 1,   REL↑, 1,  

Immune & Inflammatory Signaling ⓘ

CXCc↑, 1,   IL2↑, 1,   IL6↑, 1,   LIF↑, 1,   OSM↑, 1,  

Hormonal & Nuclear Receptors ⓘ

ARNT↑, 1,  

Clinical Biomarkers ⓘ

IL6↑, 1,  

Functional Outcomes ⓘ

toxicity∅, 1,  
Total Targets: 14

Scientific Paper Hit Count for: LIF, leukemia inhibitory factor
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:590  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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