Database Query Results : , , CLDN3

CLDN3, claudin‑3: Click to Expand ⟱
Source:
Type:
Claudin-3 is a member of the claudin family of proteins, which are integral components of tight junctions in epithelial cells. Tight junctions are crucial for maintaining the integrity of epithelial barriers, regulating paracellular permeability, and facilitating cell signaling.
Claudin-3, in particular, has been studied for its role in various cancers, and its expression levels can have significant implications for tumor behavior and patient prognosis.
Role of Claudin-3
Tight Junction Formation: Claudin-3 is involved in the formation of tight junctions, which help to maintain cell polarity and barrier function in epithelial tissues. It plays a role in regulating the permeability of the epithelial barrier.
Cell Signaling: Beyond its structural role, claudin-3 can participate in signaling pathways that influence cell proliferation, differentiation, and apoptosis.
Expression Patterns:
Overexpression: Claudin-3 is often found to be overexpressed in various cancers, including breast cancer, ovarian cancer, and pancreatic cancer. This overexpression can contribute to tumor progression and metastasis.
Loss of Expression: In some contexts, loss of claudin-3 expression can also be observed, particularly in more aggressive tumor types. This loss can disrupt tight junction integrity and promote invasiveness.
Scientific Papers found: Click to Expand⟱

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 0

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CLDN3, claudin‑3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:61  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page