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| -Promoting cell survival: Autophagosome accumulation can provide cancer cells with a means to survive under stressful conditions, such as nutrient deprivation or hypoxia. -Inducing cell death: Autophagosome accumulation can lead to cell death in certain contexts, such as in response to chemotherapy or radiation therapy. Molecular Mechanisms: mTOR Pathway: The mechanistic target of rapamycin (mTOR) is a key regulator of autophagy. Inhibition of mTOR can lead to increased autophagosome formation. Beclin-1: This protein is essential for the initiation of autophagy and is often downregulated in various cancers, affecting autophagosome formation. LC3 Protein: The conversion of LC3-I to LC3-II is a marker of autophagosome formation and is often studied in cancer research. Generally, high levels of autophagosome accumulation and autophagy-related protein expression are associated with poor prognosis in many cancers, particularly in advanced stages or in the context of treatment resistance. |
| 312- | SNP, | wortm, | Inhibition of autophagy enhances the anticancer activity of silver nanoparticles |
| - | vitro+vivo, | NA, | HeLa |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:% Target#:613 State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid