Database Query Results : , , TumCD

TumCD, Tumor Cell Death: Click to Expand ⟱

Source:

Type:

Tumor Cell Death

Scientific Papers found: Click to Expand⟱

2325-

2DG,

Research Progress of Warburg Effect in Hepatocellular Carcinoma

Review,

Var,

HK2↓, Glycolysis↓, PKM2↓, LDHA↓, TumCD↑, ChemoSen↑, eff↑,

4759-

antiOx,

Chemo,

Potential Contributions of Antioxidants to Cancer Therapy: Immunomodulation and Radiosensitization

Review,

Var,

TumCD↑, TumCG↓, ROS⇅, eff↑, RadioS↑, TumCG↓, OS↑, toxicity∅, toxicity↑,

2638-

Api,

Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death

in-vitro,

lymphoma,

PEL

TumCD↑, TumAuto↑, ROS↓, P53↑, Catalase↑, STAT3↓,

2635-

Api,

CUR,

Synergistic Effect of Apigenin and Curcumin on Apoptosis, Paraptosis and Autophagy-related Cell Death in HeLa Cells

in-vitro,

Cerv,

HeLa

TumCD↑, eff↑, TumAuto↑, ER Stress↑, Paraptosis↑, GRP78/BiP↓, Dose↝,

2003-

Ash,

Withaferin A Induces Cell Death Selectively in Androgen-Independent Prostate Cancer Cells but Not in Normal Fibroblast Cells

in-vitro,

Pca,

PC3

2 μM WA

in-vitro,

Pca,

DU145

in-vitro,

Nor,

TIG-1

in-vitro,

PC,

LNCaP

TumCD↑, selectivity↑, cFos↑, ROS↑, *ROS∅, HSP70/HSPA5↑, Apoptosis↑, ER Stress↑, TumCCA↑,

3160-

Ash,

Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal

Review,

Var,

TumCCA↑, H3↑, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,

4807-

ASTX,

An overview of the anticancer activity of astaxanthin and the associated cellular and molecular mechanisms

Review,

Var,

*antiOx↑, *neuroP↑, AntiCan↑, TumCG↓, TumCD↑, TumCMig↓, ChemoSen↑, chemoP↑, *BioAv↓, TumCP↓, TumCCA↑, Apoptosis↑, BioAv↑,

4819-

ASTX,

Astaxanthin Induces Apoptosis in MCF-7 Cells through a p53-Dependent Pathway

in-vitro,

BC,

MCF-7

5, 10, 25, 50, 75, 100, 125, and 150 μg/mL)

IC50 = 89.742 μg/mL

antiOx↑, AntiTum↑, TumCD↑, P53↑, P21↑, Apoptosis↑, Dose↝, Casp3↑,

4818-

ASTX,

MEL,

Effect of astaxanthin and melatonin on cell viability and DNA damage in human breast cancer cell lines

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

T47D

in-vitro,

Nor,

MCF10

TumCD↑, DNAdam↑, *antiOx↑, *AntiTum↑, Inflam↓, tumCV↓, Bcl-2↓, Apoptosis↓, selectivity↑, eff↑, Dose↓,

1523-

Ba,

Baicalein induces human osteosarcoma cell line MG-63 apoptosis via ROS-induced BNIP3 expression

in-vitro,

OS,

MG63

(12.5, 25, and 50 μM)

in-vitro,

Nor,

hFOB1.19

TumCD↑, Apoptosis↑, ROS↑, eff↓, Casp3↑, Bcl-2↓, selectivity↑, Cyt‑c↑, LDH?, BNIP3?, BAX↑,

2023-

BBR,

Berberine Induces Caspase-Independent Cell Death in Colon Tumor Cells through Activation of Apoptosis-Inducing Factor

in-vitro,

Colon,

0-100uM

in-vitro,

Nor,

YAMC

TumCD↑, *toxicity↓, selectivity↑, ROS↑, *ROS∅, MMP↓, *MMP∅, PARP↑, BioAv↝,

2680-

BBR,

PDT,

Photodynamic therapy-triggered nuclear translocation of berberine from mitochondria leads to liver cancer cell death

in-vitro,

Liver,

HUH7

TumCD↑, ROS↑, TumCCA↑, ER Stress↑,

2716-

BetA,

Cellular and molecular mechanisms underlying the potential of betulinic acid in cancer prevention and treatment

Review,

Var,

AntiCan↑, TumCD↑, TumCCA↑, ROS↑, NF-kB↓, Bcl-2↓, Half-Life↝, GLUT1↓, VEGF↓, PDK1↓,

2719-

BetA,

Betulinic Acid Restricts Human Bladder Cancer Cell Proliferation In Vitro by Inducing Caspase-Dependent Cell Death and Cell Cycle Arrest, and Decreasing Metastatic Potential

in-vitro,

CRC,

T24

30 μg/mL BA for 48 h

in-vitro,

Bladder,

UMUC3

33.2 μg/mL

in-vitro,

Bladder,

5637

 28.5 μg/mL

TumCD↑, Apoptosis↑, TumCCA↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK2↓, CDC25↓, mtDam↑, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Snail↓, Slug↓, MMP9↓, selectivity↑, MMP↓, ROS∅, TumCMig↓, TumCI↓,

745-

Bor,

Investigation of cytotoxic antiproliferative and antiapoptotic effects of nanosized boron phosphate filled sodium alginate composite on glioblastoma cancer cells

in-vitro,

GBM,

U87MG

in-vitro,

Nor,

L929

in-vitro,

GBM,

T98G

TumCD↑, *toxicity↓,

1640-

CA,

MET,

Caffeic Acid Targets AMPK Signaling and Regulates Tricarboxylic Acid Cycle Anaplerosis while Metformin Downregulates HIF-1α-Induced Glycolytic Enzymes in Human Cervical Squamous Cell Carcinoma Lines

in-vitro,

Cerv,

SiHa

GLS↓, NADPH↓, ROS↑, TumCD↑, AMPK↑, Hif1a↓, GLUT1↓, GLUT3↓, HK2↓, PFK↓, PKM2↓, LDH↓, cMyc↓, BAX↓, cycD1/CCND1↓, PDH↓, ROS↑, Apoptosis↑, eff↑, ACLY↓, FASN↓, Bcl-2↓, Glycolysis↓,

2791-

CHr,

Chrysin attenuates progression of ovarian cancer cells by regulating signaling cascades and mitochondrial dysfunction

in-vitro,

Ovarian,

OV90

TumCP↓, TumCD↑, ROS↑, Ca+2↑, MMP↓, MAPK↑, PI3K↑, p‑Akt↑, PCNA↓, p‑p70S6↑, p‑ERK↑, p38↑, JNK↑, DNAdam↑, TumCCA↑, chemoP↑,

4761-

CoQ10,

Elevated levels of mitochondrial CoQ10 induce ROS-mediated apoptosis in pancreatic cancer

in-vitro,

PC,

in-vivo,

PC,

MIA PaCa-2 xenograft mouse model

*ETC↝, ROS↑, *antiOx↑, ROS↑, OCR↓, MMP↓, TumCD↑, TumCG↓, other↝,

4769-

CoQ10,

CoQ10 Is Key for Cellular Energy and Cancer Support

Review,

Var,

Risk↓, TumCG↓, angioG↓, TumCD↑, *toxicity↓, *BioAv↑, MMPs↓, Inflam↓, chemoP↑, cardioP↑, *ROS↓, *toxicity↝, Dose?,

1596-

Cu,

CDT,

Unveiling the promising anticancer effect of copper-based compounds: a comprehensive review

Review,

NA,

TumCD↑, Apoptosis↓, ROS↑, angioG↑, Cupro↑, Paraptosis↑, eff↑, eff↓, selectivity↑, DNAdam↑, eff↑, eff↑, eff↑, eff↑, Fenton↑, H2O2↑, eff↑, eff↑, eff↑, RadioS↑, ChemoSen↑, eff↑, *toxicity↝, other↑, eff↑,

474-

CUR,

Modification of radiosensitivity by Curcumin in human pancreatic cancer cell lines

in-vitro,

PC,

PANC1

6, 10 and 12 µM, 24 h

in-vitro,

PC,

MIA PaCa-2

TumCD↑, Apoptosis↑, DNAdam↑, γH2AX↑, TumCCA↑,

4456-

DFE,

Induction of apoptosis and cell cycle arrest by ethyl acetate fraction of Phoenix dactylifera L. (Ajwa dates) in prostate cancer cells

in-vitro,

Pca,

PC3

TumCD↑, MMP↓, mt-ROS↑, Apoptosis↑, TumCCA↑,

1847-

dietFMD,

VitC,

Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers

in-vitro,

PC,

PANC1

vitamin C (≥0.3 mM)

TumCG↓, ChemoSen↑, eff↑, HO-1↓, Ferritin↓, Iron↑, ROS↑, TumCD↑, IGF-1↓, eff↓, eff↓,

1863-

dietFMD,

Chemo,

Effect of fasting on cancer: A narrative review of scientific evidence

Review,

Var,

eff↑, ChemoSideEff↓, ChemoSen↑, Insulin↓, HDAC↓, IGF-1↓, STAT5↓, BG↓, MAPK↓, HO-1↓, ATG3↑, Beclin-1↑, p62↑, SIRT1↑, LAMP2↑, OXPHOS↑, ROS↑, P53↑, DNAdam↑, TumCD↑, ATP↑, Treg lymp↓, M2 MC↓, CD8+↑, Glycolysis↓, GutMicro↑, GutMicro↑, Warburg↓, Dose↝,

5006-

DSF,

Cu,

Disulfiram targeting lymphoid malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition

vitro+vivo,

lymphoma,

TumCD↑, TumCP↑, Apoptosis↑, NRF2↓, ROS↑, p‑JNK↑, p65↓, eff↓, NF-kB↓,

5009-

DSF,

Cu,

Activation of Oxidative Stress and Down-Regulation of Nuclear Factor Erythroid 2-Related Factor May Be Responsible for Disulfiram/Copper Complex Induced Apoptosis in Lymphoid Malignancy Cell Lines

vitro+vivo,

lymphoma,

 (1μM) of Cu2+,

0.435±0.109μM and 0.085±0.015μM DS

AntiTum↑, ROS↑, JNK↑, NRF2↓, eff↓, TumCD↑,

5008-

DSF,

Cu,

Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis

in-vitro,

HCC,

selectivity↑, TumCD↑, TumCMig↓, TumCI↓, angioG↓, mtDam↑, Iron↑, lipid-P↑, Ferroptosis↑, NF-kB↑, p‑p62↑, Keap1↓, eff↑, eff↓, ChemoSen↑,

4915-

DSF,

Cu,

Disulfiram: A novel repurposed drug for cancer therapy

Review,

Var,

ROS↑, TumCD↑, NF-kB↓, CSCs↓, ChemoSen↑, RadioS↑, eff↑, selectivity↑, Proteasome?,

3208-

EGCG,

Induction of Endoplasmic Reticulum Stress Pathway by Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Activation of PERK/p-eIF2α/ATF4 and IRE1α

in-vitro,

Colon,

HT29

in-vitro,

Nor,

3T3

TumCD↓, ER Stress↑, GRP78/BiP↑, PERK↑, eIF2α↑, ATF4↑, IRE1↑, Apoptosis↑, Casp3↑, Casp7↑, Wnt↓, β-catenin/ZEB1↓, *toxicity∅, UPR↑,

2497-

Fenb,

In vitro anti-tubulin effects of mebendazole and fenbendazole on canine glioma cells

in-vitro,

GBM,

Dose?, selectivity↑, TumCD↑, α-tubulin↓,

2849-

FIS,

Activation of reactive oxygen species/AMP activated protein kinase signaling mediates fisetin-induced apoptosis in multiple myeloma U266 cells

in-vitro,

Melanoma,

U266

40 μg/ml

TumCD↑, TumCCA↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, p‑Akt↓, p‑mTOR↓, ROS↑, eff↓,

2518-

H2,

Hydrogen Therapy Reverses Cancer-Associated Fibroblasts Phenotypes and Remodels Stromal Microenvironment to Stimulate Systematic Anti-Tumor Immunity

in-vitro,

BC,

4T1

CaCO3 nanoparticles-coated magnesium system (Mg-CaCO3) is developed.

in-vitro,

Nor,

3T3

TumCD↑, CD4+↑, ROS↓,

2073-

HNK,

Honokiol induces apoptosis and autophagy via the ROS/ERK1/2 signaling pathway in human osteosarcoma cells in vitro and in vivo

in-vitro,

OS,

U2OS

21.5 μM

in-vivo,

NA,

40 mg/kg

TumCD↑, TumAuto↑, Apoptosis↑, TumCCA↑, GRP78/BiP↑, ROS↑, eff↓, p‑ERK↑, selectivity↑, Ca+2↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bcl-2↓, Bcl-xL↓, survivin↓, LC3B-II↑, ATG5↑, TumVol↓, TumW↓, ER Stress↑,

869-

Lae,

Recent updates and future perspectives about amygdalin as a potential anticancer agent: A review

TumCD↑,

2923-

LT,

Luteolin induces apoptosis through endoplasmic reticulum stress and mitochondrial dysfunction in Neuro-2a mouse neuroblastoma cells

in-vitro,

NA,

Apoptosis↑, TumCD↑, Casp12↑, Casp9↑, Casp3↑, ER Stress↑, CHOP↑, GRP78/BiP↑, GRP94↑, cl‑ATF6↑, p‑eIF2α↑, MMP↓, JNK↓, p38↑, ERK↑, Cyt‑c↑,

2546-

M-Blu,

SDT,

The sonodynamic antitumor effect of methylene blue on sarcoma180 cells in vitro

in-vitro,

sarcoma,

S180

1,10,100uM  0.24 W/cm(2) for 30 seconds

TumCD↑,

1785-

MEL,

Antitumoral melatonin-loaded nanostructured lipid carriers

in-vitro,

Var,

selectivity↑, TumCD↑,

995-

MEL,

Melatonin Treatment Triggers Metabolic and Intracellular pH Imbalance in Glioblastoma

vitro+vivo,

GBM,

1.5 and 3.0 mM

five glioma tumor initiating cell lines (GBM1A [15], QNS120, GBM612, GBM965, and QNS108

LDHA↓, MCT4↓, lactateProd↓, i-pH↓, ROS↑, ATP↓, TumCD↑, TumCCA↑, PDH↓, Glycolysis↓, GlucoseCon↓, TumCG↓,

2235-

MF,

Increase of intracellular Ca2+ concentration in Listeria monocytogenes under pulsed magnetic field

in-vitro,

Inf,

~7mT, us duration, repeat every second

Ca+2↑, TumCD↑,

523-

MF,

MTX,

Extremely low-frequency magnetic fields significantly enhance the cytotoxicity of methotrexate and can reduce migration of cancer cell lines via transiently induced plasma membrane damage

in-vitro,

AML,

THP1

10uM(MTX), 0.1 and 0.6 μT

in-vitro,

NA,

PC12

pheocrmomocytoma (PC12) Pheochromocytoma is a type of tumor

in-vivo,

Cerv,

HeLa

H2O2↑, TumCD↑, CellMemb↑, eff↑,

528-

MF,

Caff,

Pulsed electromagnetic fields affect the intracellular calcium concentrations in human astrocytoma cells

in-vitro,

GBM,

U373MG

3mT, 50Hz

Ca+2↑, TumCP∅, TumCD∅, eff↑,

533-

MF,

Effects of extremely low-frequency magnetic fields on human MDA-MB-231 breast cancer cells: proteomic characterization

in-vitro,

BC,

MDA-MB-231

1mT, 50Hz for 4 h

in-vitro,

Nor,

MCF10

TumCD↑, necrosis↑, mt-ROS↑, other↑, *STAT3↓, STAT3↑,

184-

MFrot,

MF,

Rotating Magnetic Fields Inhibit Mitochondrial Respiration, Promote Oxidative Stress and Produce Loss of Mitochondrial Integrity in Cancer Cells

in-vitro,

GBM,

GBM

 80mT pulsed

ROS↑, mitResp↓, mtDam↑, Dose↝, MMP?, OCR↓, mt-H2O2↑, eff↓, SDH↓, Thiols↓, GSH↓, TumCD↑, Casp3↑, Casp7↑, MPT↑, Cyt‑c↑, selectivity↑, GSH/GSSG↓, ETC↓,

186-

MFrot,

MF,

Selective induction of rapid cytotoxic effect in glioblastoma cells by oscillating magnetic fields

in-vitro,

GBM,

GBM

 new device that generates oscillating magnetic fields (OMF) by rapid rotation of strong permanent magnets in specially designed patterns of frequency and timing

in-vitro,

Lung,

mt-ROS↑, Casp3↑, selectivity↑, TumCD↑, ETC↓,

595-

MFrot,

VitC,

MF,

The Effect of Alternating Magnetic Field Exposure and Vitamin C on Cancer Cells

in-vitro,

PC,

MIA PaCa-2

4mT, 1000rpm

51% reduction

reduces IC50 value of cells treated with Vit C and magnetic field

in-vitro,

CRC,

SW-620

23% reduction

in-vitro,

NA,

HT1080

37% reduction

in-vitro,

Pca,

PC3

40% reduction

in-vitro,

OS,

U2OS

46% reduction

in-vitro,

BC,

MCF-7

33% reduction

in-vitro,

Nor,

CCD-18Co

-7% reduction

health normal colon cells *****

TumCD↑, eff↑, *TumCG∅,

3492-

MFrot,

Chemo,

MF,

Synergistic Effect of Chemotherapy and Magnetomechanical Actuation of Fe-Cr-Nb-B Magnetic Particles on Cancer Cells

eff↑, TumCD↑,

3493-

MFrot,

MF,

Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes

in-vivo,

GBM,

20 ± 2 mT and a rotating frequency of 20 Hz

TumCD↑, MMP↓, Cyt‑c↑, Apoptosis↑, OS↑, DNAdam↑,

3494-

MFrot,

MF,

Magnetically switchable mechano-chemotherapy for enhancing the death of tumour cells by overcoming drug-resistance

in-vitro,

Var,

eff↑, TumCD↑,

2258-

MFrot,

MF,

EXTH-68. ONCOMAGNETIC TREATMENT SELECTIVELY KILLS GLIOMA CANCER CELLS BY INDUCING OXIDATIVE STRESS AND DNA DAMAGE

in-vitro,

GBM,

GBM

in-vitro,

Nor,

SVGp12

TumVol↓, OS↑, γH2AX↑, DNAdam↑, selectivity↑, ROS↑, TumCD↑, eff↑, eff↓,

4970-

Nimb,

Insights into Nimbolide molecular crosstalk and its anticancer properties

Review,

Var,

chemoPv↑, Apoptosis↑, TumCP↓, TumCD↑, TumMeta↓, angioG↓,

2039-

PB,

TXNIP mediates the differential responses of A549 cells to sodium butyrate and sodium 4‐phenylbutyrate treatment

in-vitro,

Lung,

A549

in-vitro,

Nor,

HEK293

TXNIP↑, Casp3↑, Casp7↑, mt-ROS↑, GlucoseCon↓, TumCP↓, TumCD↑, IGF-2↑, HDAC↓, ROS⇅,

2078-

PB,

Butyrate-induced apoptosis in HCT116 colorectal cancer cells includes induction of a cell stress response

in-vitro,

CRC,

HCT116

0-20mM

p38↑, ER Stress↑, Casp3↑, Casp7↑, TumCD↑, Apoptosis↑, TumCP↑, HSP27↓,

4955-

PEITC,

Phenethyl isothiocyanate-induced cytoskeletal changes and cell death in lung cancer cells

in-vitro,

Lung,

A549

in-vitro,

Lung,

H1299

TumCG↓, α-tubulin↓, TumCD↑, TumCCA↑, Apoptosis↑,

4954-

PEITC,

Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate

vitro+vivo,

Ovarian,

SKOV3

 5 μM

ROS↑, GSH↓, selectivity↑, mtDam↑, TumCD↑, OS↑, eff↑, *toxicity↓, H2O2↑, NO↑, eff↓, GPx↓, Dose↝, eff↑,

4953-

PEITC,

PEITC: a natural compound effective in killing primary leukemia cells and overcoming drug resistance

in-vitro,

CLL,

 4-8 µM

ROS↑, GSH↓, TumCD↓, eff↓, Mcl-1↓, Casp3↑,

4948-

PEITC,

Sensory acceptable equivalent doses of β-phenylethyl isothiocyanate (PEITC) induce cell cycle arrest and retard the growth of p53 mutated oral cancer in vitro and in vivo

vitro+vivo,

Oral,

CAL27

vitro+vivo,

Oral,

FaDu

vitro+vivo,

Oral,

SCC4

vitro+vivo,

Oral,

SCC9

TumCD↑, TumCG↓, OS↑, ROS↑, P53↑, P21↑, TumCCA↑, Ki-67↓,

4943-

PEITC,

Phenethyl isothiocyanate (PEITC) inhibits growth of ovarian cancer cells by inducing apoptosis: role of caspase and MAPK activation

in-vitro,

Ovarian,

OVCAR-3

23.2 microM

TumCD↑, TumCP↓, Apoptosis↑, Casp3↑, Casp9↑, Bcl-2↓, BAX↑, Akt↓, ERK↓, cMyc↓, p38↑, JNK↑, eff↓,

1765-

PG,

Enhanced cell death effects of MAP kinase inhibitors in propyl gallate-treated lung cancer cells are related to increased ROS levels and GSH depletion

in-vitro,

Lung,

A549

800 uM at 24 h

in-vitro,

Lung,

Calu-6

TumCD↑, MMP↓, ROS↑, GSH↓, Dose∅, eff↑,

2943-

PL,

Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin

in-vitro,

CRC,

HCT116

in-vitro,

Lung,

A549

in-vitro,

BC,

MCF-7

TrxR1?, TumCD↑, ROS↑, GSH↓, eff↑,

3381-

QC,

Quercetin induces cell death in cervical cancer by reducing O-GlcNAcylation of adenosine monophosphate-activated protein kinase

in-vitro,

Cerv,

HeLa

SREBP1↓, TumCP↓, TumCD↑, AMPK↑, SREBP1↓, FASN↓, ACC↓,

3378-

QC,

CK2 and PI3K are direct molecular targets of quercetin in chronic lymphocytic leukaemia

in-vitro,

AML,

CK2↓, PI3K↓, TumCD↑, Akt↓, Mcl-1↓, PTEN↑,

884-

RES,

PTS,

Resveratrol and Pterostilbene Exhibit Anticancer Properties Involving the Downregulation of HPV Oncoprotein E6 in Cervical Cancer Cells

in-vitro,

Cerv,

HeLa

pterostilbene displayed a 1.97-fold lower IC50 when compared to resveratrol (42.3 µM vs. 83.5 µM

TumCD↑, TumCCA↑, E6↓, Casp3↑, P53↑,

3017-

RosA,

Per,

Molecular Mechanism of Antioxidant and Anti-Inflammatory Effects of Omega-3 Fatty Acids in Perilla Seed Oil and Rosmarinic Acid Rich Fraction Extracted from Perilla Seed Meal on TNF-α Induced A549 Lung Adenocarcinoma Cells

in-vitro,

Lung,

A549

TumCD∅, ROS↓, IL1β↓, IL6↓, IL8↓, TNF-α↓, COX2↓, SOD2↓, FOXO1↓, NF-kB↓, JNK↓, antiOx↑, tumCV∅,

4912-

Sal,

Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells

in-vitro,

Lung,

A549

2.5 μM

in-vitro,

Lung,

H460

in-vitro,

Lung,

Calu-1

in-vitro,

Lung,

H157

CSCs↓, TumAuto↑, ER Stress↑, TumCD↑, ATF4↑, CHOP↑, AKT1↓, mTOR↓,

4909-

Sal,

Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model

vitro+vivo,

CRC,

AntiTum↑, Apoptosis↑, mtDam↑, ROS↑, SOD1↓, ChemoSen↑, CSCs↑, ALDH↓, TumCG↓, TumCP↓, TumCD↑, ATP↓,

323-

Sal,

SNP,

Combination of salinomycin and silver nanoparticles enhances apoptosis and autophagy in human ovarian cancer cells: an effective anticancer therapy

in-vitro,

BC,

MDA-MB-231

 Sal (3 µM), AgNPs (4 µg/mL)

 IC25 values of both Sal and AgNPs (3.0 µM and 4 µg/mL)

in-vitro,

Ovarian,

A2780S

TumCD↑, LDH↓, MDA↑, SOD↓, ROS↑, GSH↓, Catalase↓, MMP↓, P53↑, P21↑, BAX↑, Bcl-2↓, Casp3↑, Casp9↑, Apoptosis↑, TumAuto↑,

4745-

Se,

Chemo,

Translational Selenium Nanoparticles Promotes Clinical Non-small-cell Lung Cancer Chemotherapy via Activating Selenoprotein-driven Immune Manipulation

Study,

NSCLC,

Risk↓, TumCD↑, mTOR↑, AntiTum↑, ChemoSen↑,

1732-

SFN,

Sulforaphane, a Dietary Component of Broccoli/Broccoli Sprouts, Inhibits Breast Cancer Stem Cells

in-vitro,

BC,

MCF-7

1~5 μM

16 μM

in-vitro,

BC,

SUM159

10 μM

in-vivo,

NA,

Daily injection with 50 mg/kg

mice

TumCD↑, CSCs↓, Wnt↓, β-catenin/ZEB1↓, *BioAv↑, angioG↓, VEGF↓, Hif1a↓, MMP2↓, MMP9↓, Casp3↑, *Half-Life∅,

3323-

SIL,

Anticancer therapeutic potential of silibinin: current trends, scope and relevance

Review,

Var,

Inflam↓, angioG↓, antiOx↑, TumMeta↓, TumCP↓, TumCCA↑, TumCD↑, α-SMA↓, p‑Akt↓, p‑STAT3↓, COX2↓, IL6↓, MMP2↓, HIF-1↓, Snail↓, Slug↓, Zeb1↓, NF-kB↓, p‑EGFR↓, JAK2↓, PI3K↓, PD-L1↓, VEGF↓, CDK4↓, CDK2↓, cycD1/CCND1↓, E2Fs↓,

2227-

SK,

Shikonin induces mitochondria-mediated apoptosis and enhances chemotherapeutic sensitivity of gastric cancer through reactive oxygen species

in-vitro,

GC,

BGC-823

13.35uM

in-vitro,

GC,

SGC-7901

9.63uM

in-vitro,

Nor,

GES-1

>20 μM

selectivity↑, TumCP↓, TumCD↑, ROS↑, MMP↓, Casp↑, Cyt‑c↑, Endon↑, AIF↑, eff↓, ChemoSen↑, TumCCA↑, GSH/GSSG↓, lipid-P↑,

338-

SNP,

Biogenic silver nanoparticles: In vitro and in vivo antitumor activity in bladder cancer

vitro+vivo,

Bladder,

5637

 mice

TumCD↑, Apoptosis↑, TumCMig↓, TumCP↓,

339-

SNP,

Cancer cell specific cytotoxic potential of the silver nanoparticles synthesized using the endophytic fungus, Penicillium citrinum CGJ-C2

in-vitro,

BC,

MCF-7

in-vitro,

Melanoma,

A431

in-vitro,

HCC,

HepG2

TumCD↑,

340-

SNP,

Screening bioactivities of Caesalpinia pulcherrima L. swartz and cytotoxicity of extract synthesized silver nanoparticles on HCT116 cell line

in-vitro,

CRC,

HCT116

 18ug

TumCD↑,

341-

SNP,

Bioprospecting a native silver-resistant Bacillus safensis strain for green synthesis and subsequent antibacterial and anticancer activities of silver nanoparticles

in-vitro,

Liver,

HepG2

TumCD↑, ROS↑,

352-

SNP,

Synthesis of silver nanoparticles (Ag NPs) for anticancer activities (MCF 7 breast and A549 lung cell lines) of the crude extract of Syzygium aromaticum

in-vitro,

BC,

MCF-7

TumCD↑,

354-

SNP,

Silver nanoparticles induce SH-SY5Y cell apoptosis via endoplasmic reticulum- and mitochondrial pathways that lengthen endoplasmic reticulum-mitochondria contact sites and alter inositol-3-phosphate receptor function

in-vitro,

neuroblastoma,

SH-SY5Y

  Ca2+ overload and disrupted homeostasis in the mitochondria triggered apoptotic cell death.

TumCD↑, ER Stress↑, GRP78/BiP↑, p‑PERK↑, CHOP↑, Ca+2↑, XBP-1↑, p‑IRE1↑,

364-

SNP,

Differential Action of Silver Nanoparticles on ABCB1 (MDR1) and ABCC1 (MRP1) Activity in Mammalian Cell Lines

in-vitro,

Lung,

A549

 202ug/cm3

 most resistant

in-vitro,

Hepat,

HepG2

 15.8ug/cm3

 Decreased mRNA expression of most ABC transporters (not ABCB1)

in-vitro,

CRC,

SW-620

 39.4ug/cm3

 Increased mRNA expression of most ABC transporters (not ABCB1)

TumCD↑,

365-

SNP,

Silver nanoparticles affect glucose metabolism in hepatoma cells through production of reactive oxygen species

in-vitro,

Hepat,

HepG2

 0.5–7.5 µg/mL 5 nm

ROS↑, GlucoseCon↓, TumCD↑, NRF2↓,

4541-

SNP,

RosA,

Eco-friendly synthesis of silver nanoparticles: multifaceted antioxidant, antidiabetic, anticancer, and antimicrobial activities

in-vitro,

Nor,

WI38

in-vitro,

BC,

MDA-MB-231

in-vitro,

PC,

PANC1

*antiOx↑, TumCD↓, selectivity↑,

4430-

SNP,

Evaluation of the Genotoxic and Oxidative Damage Potential of Silver Nanoparticles in Human NCM460 and HCT116 Cells

in-vitro,

Colon,

HCT116

20 nm

in-vitro,

Nor,

NCM460

*Bacteria↓, ROS↑, p‑p38↑, BAX↑, Bcl-2↓, BAX↑, P21↑, TumCD↑, toxicity↝,

4439-

SNP,

Anticancer Potential of Green Synthesized Silver Nanoparticles Using Extract of Nepeta deflersiana against Human Cervical Cancer Cells (HeLA)

in-vitro,

Cerv,

HeLa

33 nm

ROS↑, lipid-P↑, MMP↓, GSH↓, TumCCA↑, Apoptosis↑, Necroptosis↑, TumCD↑, Dose↝,

4661-

SNP,

Silver nanoparticles induces apoptosis of cancer stem cells in head and neck cancer

in-vitro,

HNSCC,

TumCD↑, CSCs↝,

4379-

SNP,

Exposure to silver nanoparticles induces size- and dose-dependent oxidative stress and cytotoxicity in human colon carcinoma cells

in-vitro,

CRC,

LoVo

eff↑, TumCD↑, ROS↑, Bacteria↓,

4374-

SNP,

Enhancing antitumor activity of silver nanoparticles by modification with cell-penetrating peptides

in-vitro,

BC,

MCF-7

eff↑, TumCD↑,

4373-

SNP,

In vitro toxicity of silver nanoparticles at noncytotoxic doses to HepG2 human hepatoma cells

in-vitro,

Liver,

HepG2

TumCD↑,

4372-

SNP,

Negligible particle-specific toxicity mechanism of silver nanoparticles: the role of Ag+ ion release in the cytosol

in-vitro,

Cerv,

HeLa

in-vitro,

Lung,

A549

TumCD↑,

4402-

SNP,

Enhancement of Triple-Negative Breast Cancer-Specific Induction of Cell Death by Silver Nanoparticles by Combined Treatment with Proteotoxic Stress Response Inhibitors

in-vitro,

BC,

BT549

in-vitro,

BC,

MDA-MB-231

in-vitro,

Nor,

MCF10

TumCD↑, selectivity↑, *toxicity↝, Dose↝, OS↑,

4406-

SNP,

Silver nanoparticles achieve cytotoxicity against breast cancer by regulating long-chain noncoding RNA XLOC_006390-mediated pathway

in-vitro,

BC,

MCF-7

63.1 ± 8.3 nm

tissues from 64 patients

in-vitro,

BC,

T47D

in-vitro,

BC,

MDA-MB-231

TumCD↑, other↓, P53↑, TumCCA↑, Apoptosis↑, ChemoSen↑, tumCV↓, γH2AX↑, SOX4↓,

4364-

SNP,

Selective cytotoxicity of green synthesized silver nanoparticles against the MCF-7 tumor cell line and their enhanced antioxidant and antimicrobial properties

in-vitro,

BC,

MCF-7

31.4 nm with a Zeta potential of −33.8 mV,

TumCD↑, selectivity↑, *antiOx↑, *Inflam↓, AntiTum↑, ROS↑,

4361-

SNP,

GoldNP,

Biocompatible silver, gold and silver/gold alloy nanoparticles for enhanced cancer therapy: in vitro and in vivo perspectives

in-vivo,

Liver,

HepG2

IC50 values of the AgNPs, AuNPs and Ag/AuNPs on HepG2 cells were determined as 38.42 μg ml-1, 43.25 μg ml-1 and 39.20 μg ml-1

Sprague Dawley (SD) rat model

TumCD↑, TumVol↓, *toxicity↝, hepatoP↑,

4358-

SNP,

HPT,

Rad,

Silver nanocrystals mediated combination therapy of radiation with magnetic hyperthermia on glioma cells

in-vitro,

GBM,

U251

10 nm silver nanoparticles (AgNPs) on human glioma U251 c

RadioS↑, eff↑, TumCD↑,

4891-

Sper,

Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms

Review,

Var,

Review,

AD,

TumCCA↑, TumCP↓, TumCG↓, *Inflam↓, *antiOx↑, *neuroP↑, *cognitive↑, *Aβ↓, *mitResp↑, AntiCan↑, TumCD↑, TumAuto↑, *AntiAge↑, LC3B-II↑, ATG5↑, Beclin-1↑, mt-ROS↑, H2O2↑, Apoptosis↑, *ROS↑, ChemoSen↑, MMP↓, Cyt‑c↑,

2093-

TQ,

Regulation of NF-κB Expression by Thymoquinone; A Role in Regulating Pro-Inflammatory Cytokines and Programmed Cell Death in Hepatic Cancer Cells

in-vitro,

Liver,

HepG2

TQ (125–1000 ug/mL).

in-vitro,

Nor,

TumCD↑, selectivity↑, Casp3↑, DLC1↑, NF-kB↑, LDH↑, *toxicity↓,

4835-

Uro,

Urolithin A, induces apoptosis and autophagy crosstalk in Oral Squamous Cell Carcinoma via mTOR /AKT/ERK1/2 pathway

in-vitro,

SCC,

TumCD↑, ER Stress↑, Akt↓, mtDam↓, p‑mTOR↓, *BioAv↝, ROS↑, TumCCA↑, Apoptosis↑, ERK↓,

1819-

VitC,

VitK3,

The association of vitamins C and K3 kills cancer cells mainly by autoschizis, a novel form of cell death. Basis for their potential use as coadjuvants in anticancer therapy

Review,

Var,

Dose?, TumCD↑, selectivity↑, H2O2↑, ROS↑, DNAdam↑,

628-

VitC,

Mg,

Enhanced Anticancer Effect of Adding Magnesium to Vitamin C Therapy: Inhibition of Hormetic Response by SVCT-2 Activation

in-vivo,

Colon,

CT26

mouse

in-vitro,

NA,

MCF-7

 1–10 mM(Mg)

(MgSO4 and MgCl2) no cytotoxicity at any of the tested concentrations.

in-vitro,

NA,

SkBr3

AntiCan↑, SVCT-2↝, TumCD↑, ROS↑, P21↑, proCasp3↑, TumVol↓, DNAdam↑, NAD↓,

600-

VitC,

VitK3,

Serum markers variation consistent with autoschizis induced by ascorbic acid-menadione in patients with prostate cancer

in-vitro,

NA,

autoS↑, TumCD↑,

611-

VitC,

Characterization of a new malignant human T-cell line (PFI-285) sensitive to ascorbic acid

in-vitro,

NA,

50 mumol/l

TumCD↑,

3136-

VitC,

Vitamin C uncouples the Warburg metabolic switch in KRAS mutant colon cancer

in-vitro,

Colon,

SW48

in-vitro,

Colon,

LoVo

ERK↓, p‑PKM2↓, GLUT1↓, Warburg↓, TumCD↑, eff↑, ROS↓, cMyc↓,

4468-

VitC,

Se,

Selenium modulates cancer cell response to pharmacologic ascorbate

in-vivo,

GBM,

U87MG

in-vitro,

CRC,

HCT116

eff↓, TumCD↑, ChemoSen↑, ROS⇅, DNAdam↑, PARP↑, NAD↓, Glycolysis↓, Fenton↑, lipid-P↑, eff↓, H2O2↑, other↝,

1835-

VitK3,

VitC,

Potential therapeutic application of the association of vitamins C and K3 in cancer treatment

Review,

Var,

ROS↑, TumCD↑, TumCG↓, OS↑,

1821-

VitK3,

Menadione (Vitamin K3) induces apoptosis of human oral cancer cells and reduces their metastatic potential by modulating the expression of epithelial to mesenchymal transition markers and inhibiting migration

in-vitro,

Oral,

in-vitro,

Nor,

HEK293

in-vitro,

Nor,

HaCaT

selectivity↑, TumCD↓, BAX↑, P53↑, Bcl-2↓, p65↓, E-cadherin↑, EMT↓, Vim↓, Fibronectin↓, TumCG↓, TumCMig↓,

1760-

WBV,

Molecular jackhammers eradicate cancer cells by vibronic-driven action

in-vitro,

Melanoma,

TumCD↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 103

Pathway results for Effect on Cancer / Diseased Cells:

Infection & Microbiome ⓘ

Bacteria↓, 1, CD8+↑, 1,
Total Targets: 295

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

antiOx↑, 6, Prx↑, 1, ROS↓, 1, ROS↑, 1, ROS∅, 2, SOD2↑, 1,

Mitochondria & Bioenergetics ⓘ

ETC↝, 1, mitResp↑, 1, MMP∅, 1,

Cell Death ⓘ

Casp3?, 1,

Proliferation, Differentiation & Cell State ⓘ

STAT3↓, 1, TumCG∅, 1,

Immune & Inflammatory Signaling ⓘ

Inflam↓, 2,

Protein Aggregation ⓘ

Aβ↓, 1,

Drug Metabolism & Resistance ⓘ

BioAv↓, 1, BioAv↑, 2, BioAv↝, 1, Half-Life∅, 1,

Functional Outcomes ⓘ

AntiAge↑, 1, AntiTum↑, 1, cognitive↑, 1, neuroP↑, 2, toxicity↓, 6, toxicity↝, 4, toxicity∅, 1,

Infection & Microbiome ⓘ

Bacteria↓, 1,
Total Targets: 26

Scientific Paper Hit Count for: TumCD, Tumor Cell Death

22 Silver-NanoParticles
11 Magnetic Fields
9 Vitamin C (Ascorbic Acid)
7 Magnetic Field Rotating
5 Copper and Cu NanoParticlex
5 Phenethyl isothiocyanate
4 Chemotherapy
4 Disulfiram
4 VitK3,menadione
3 Astaxanthin
3 Melatonin
3 salinomycin
2 Apigenin (mainly Parsley)
2 Curcumin
2 Ashwagandha(Withaferin A)
2 Berberine
2 Betulinic acid
2 Coenzyme Q10
2 diet FMD Fasting Mimicking Diet
2 Phenylbutyrate
2 Quercetin
2 Rosmarinic acid
2 Selenium
1 2-DeoxyGlucose
1 Anti-oxidants
1 Baicalein
1 Photodynamic Therapy
1 Boron
1 Caffeic acid
1 Metformin
1 Chrysin
1 chemodynamic therapy
1 Date Fruit Extract
1 EGCG (Epigallocatechin Gallate)
1 Fenbendazole
1 Fisetin
1 Hydrogen Gas
1 Honokiol
1 Laetrile B17 Amygdalin
1 Luteolin
1 Methylene blue
1 SonoDynamic Therapy UltraSound
1 methotrexate
1 Caffeine
1 Nimbolide
1 Propyl gallate
1 Piperlongumine
1 Resveratrol
1 Pterostilbene
1 Perilla
1 Sulforaphane (mainly Broccoli)
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Gold NanoParticles
1 Hyperthermia
1 Radiotherapy/Radiation
1 Spermidine
1 Thymoquinone
1 Urolithin
1 Magnesium
1 Whole Body Vibration

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:619  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

Database Query Results : , , TumCD

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned ⓘ

Redox & Oxidative Stress ⓘ

Metal & Cofactor Biology ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Kinase & Signal Transduction ⓘ

Transcription & Epigenetics ⓘ

Protein Folding & ER Stress ⓘ

Autophagy & Lysosomes ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Cellular Microenvironment ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Infection & Microbiome ⓘ

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

Mitochondria & Bioenergetics ⓘ

Cell Death ⓘ

Proliferation, Differentiation & Cell State ⓘ

Immune & Inflammatory Signaling ⓘ

Protein Aggregation ⓘ

Drug Metabolism & Resistance ⓘ

Functional Outcomes ⓘ

Infection & Microbiome ⓘ

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