Database Query Results : , , NADPH

NADPH, Nicotinamide adenine dinucleotide phosphate: Click to Expand ⟱
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NADPH (Nicotinamide adenine dinucleotide phosphate) is a crucial molecule in cellular metabolism, playing a key role in various biological processes, including energy production, antioxidant defenses, and biosynthesis.
NADPH is essential for the proper functioning of the pentose phosphate pathway, which generates NADPH and ribose-5-phosphate. Cancer cells may exploit this pathway to support their high energy demands.
Many types of cancer, including breast, lung, and colon cancer, exhibit increased NADPH levels compared to normal tissues. This increase is often associated with enhanced glucose-6-phosphate dehydrogenase (G6PD) activity, a key enzyme in the pentose phosphate pathway that generates NADPH.
Scientific Papers found: Click to Expand⟱
2327- 2DG,    2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents
- Review, Var, NA
Glycolysis↓, HK2↓, mt-ROS↑, AMPK↑, PPP↓, NADPH↓, GSH↓, Bax:Bcl2↑, Apoptosis↑, RadioS↑, eff↓, Half-Life↓, other↝, eff↓,
5277- 3BP,    3-Bromopyruvate inhibits pancreatic tumor growth by stalling glycolysis, and dismantling mitochondria in a syngeneic mouse model
- in-vivo, PC, Panc02
HK2↓, selectivity↑, ATP↓, mtDam↑, Dose↝, TumCG↓, Casp3↑, Glycolysis↓, NADPH↓, ATP↓, ROS↑, DNAdam↑, GSH↓, Bcl-2↓, Casp↑, lactateProd↓,
278- ALA,    The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment
- Review, NA, NA
ROS↑, NRF2↑, Inflam↓, frataxin↑, *BioAv↓, ChemoSen↑, Hif1a↓, eff↑, FAK↓, ITGB1↓, MMP2↓, MMP9↓, EMT↓, Snail↓, Vim↓, Zeb1↓, P53↑, MGMT↓, Mcl-1↓, Bcl-xL↓, Bcl-2↓, survivin↓, Casp3↑, Casp9↑, BAX↑, p‑Akt↓, GSK‐3β↓, *antiOx↑, *ROS↓, selectivity↑, angioG↓, MMPs↓, NF-kB↓, ITGB3↓, NADPH↓,
3269- ALA,    Sulfur-containing therapeutics in the treatment of Alzheimer’s disease
- NA, AD, NA
*AChE↓, *GlucoseCon↑, *ACC↑, *GSH↑, *Aβ↓, *Catalase↑, *GSR↑, *GSTs↑, *NADPH↑, *NQO1↑, *iNOS↓, *NF-kB↓, *lipid-P↓, *BBB↑, *memory↑, *cognitive↑, *antiOx↑, *Inflam↓,
2639- Api,    Plant flavone apigenin: An emerging anticancer agent
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoPv↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1/CCND1↓, CycD3↓, p27↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,
206- Api,    Inhibition of glutamine utilization sensitizes lung cancer cells to apigenin-induced apoptosis resulting from metabolic and oxidative stress
- in-vitro, Lung, H1299 - in-vitro, Lung, H460 - in-vitro, Lung, A549 - in-vitro, CRC, HCT116 - in-vitro, Melanoma, A375 - in-vitro, Lung, H2030 - in-vitro, CRC, SW480
Glycolysis↓, lactateProd↓, PGK1↓, ALDOA↓, GLUT1↓, ENO1↓, ATP↓, Casp9↑, Casp3↑, cl‑PARP↑, PI3K/Akt↓, HK1↓, HK2↓, ROS↑, Apoptosis↑, eff↓, NADPH↓, PPP↓,
3382- ART/DHA,    Repurposing Artemisinin and its Derivatives as Anticancer Drugs: A Chance or Challenge?
- Review, Var, NA
AntiCan↑, toxicity↑, Ferroptosis↑, ROS↑, TumCCA↑, BioAv↝, eff↝, Half-Life↓, Ferritin↓, GPx4↓, NADPH↓, GSH↓, BAX↑, Cyt‑c↑, cl‑Casp3↑, VEGF↓, IL8↓, COX2↓, MMP9↓, E-cadherin↑, MMP2↓, NF-kB↓, p16↑, CDK4↓, cycD1/CCND1↓, p62↓, LC3II↑, EMT↓, CSCs↓, Wnt↓, β-catenin/ZEB1↓, uPA↓, TumAuto↑, angioG↓, ChemoSen↑,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
1421- Bos,    Coupling of boswellic acid-induced Ca2+ mobilisation and MAPK activation to lipid metabolism and peroxide formation in human leucocytes
- in-vitro, AML, HL-60 - in-vitro, Nor, NA
ROS↑, NADPH↝, 5LO↓, Ca+2↑, p38↑, p42↑,
1640- CA,  MET,    Caffeic Acid Targets AMPK Signaling and Regulates Tricarboxylic Acid Cycle Anaplerosis while Metformin Downregulates HIF-1α-Induced Glycolytic Enzymes in Human Cervical Squamous Cell Carcinoma Lines
- in-vitro, Cerv, SiHa
GLS↓, NADPH↓, ROS↑, TumCD↑, AMPK↑, Hif1a↓, GLUT1↓, GLUT3↓, HK2↓, PFK↓, PKM2↓, LDH↓, cMyc↓, BAX↓, cycD1/CCND1↓, PDH↓, ROS↑, Apoptosis↑, eff↑, ACLY↓, FASN↓, Bcl-2↓, Glycolysis↓,
2652- CAP,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
chemoPv↑, AntiCan↑, ROS↑, TumCG↓, ROS↑, MMP↑, Apoptosis↑, TumCCA↑, JNK↑, SOD↓, Catalase↓, GPx↓, other↓, SIRT1↓, NADPH↑, FOXO3↑,
2590- CHr,    Chrysin suppresses proliferation, migration, and invasion in glioblastoma cell lines via mediating the ERK/Nrf2 signaling pathway
- in-vitro, GBM, T98G - in-vitro, GBM, U251 - in-vitro, GBM, U87MG
TumCP↓, TumCMig↓, TumCI↓, NRF2↓, HO-1↓, NADPH↓, ERK↓,
2786- CHr,    Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, TumCI↓, TumMeta↑, *toxicity↓, selectivity↑, chemoPv↑, *GSTs↑, *NADPH↑, *GSH↑, HDAC8↓, Hif1a↓, *ROS↓, *NF-kB↓, SCF↓, cl‑PARP↑, survivin↓, XIAP↓, Casp3↑, Casp9↑, GSH↓, ChemoSen↑, Fenton↑, P21↑, P53↑, cycD1/CCND1↓, CDK2↓, STAT3↓, VEGF↓, Akt↓, NRF2↓,
1485- CUR,  Chemo,  Rad,    Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs
- Review, Var, NA
ChemoSen↑, NF-kB↓, *STAT3↓, *COX2↓, *Akt↓, *NRF2↑, *HO-1↑, *GPx↑, *NADPH↑, *GSH↑, *ROS↓, *p300↓, radioP↑, chemoP↑, RadioS↑,
3795- CUR,    Curcumin: A Golden Approach to Healthy Aging: A Systematic Review of the Evidence
- Review, AD, NA
*antiOx↑, *Inflam↓, *AntiAge↑, *AMPK↑, *SIRT1↑, *NF-kB↓, *mTOR↓, *NLRP3↓, *NADPH↓, *ROS↓, *COX2↓, *MCP1↓, *IL1β↓, *IL17↓, *IL23↓, *TNF-α↓, *MPO↓, *IL10↑, *lipid-P↓, *SOD↑, *Aβ↓, *p‑tau↓, *GSK‐3β↓, *CDK5↓, *TXNIP↓, *NRF2↑, *NQO1↑, *HO-1↑, *OS↑, *memory↑, *BDNF↑, *neuroP↑, *BACE↓, *AChE↓, *LDL↓,
2654- CUR,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
ROS↑, Catalase↓, SOD1↓, GLO-I↓, NADPH↓, TumCCA↑, Apoptosis↑, Akt↓, ER Stress↑, JNK↑, STAT3↓, BioAv↑,
1854- dietFMD,    How Far Are We from Prescribing Fasting as Anticancer Medicine?
- Review, Var, NA
ChemoSideEff↓, ChemoSen↑, IGF-1↓, IGFBP1↑, adiP↑, glyC↓, E-cadherin↑, MMPs↓, Casp3↑, ROS↑, ATP↓, AMPK↑, mTOR↓, ROS↑, Glycolysis↓, NADPH↓, OXPHOS↝, eff↑, eff↑, *RAS↓, *MAPK↓, *PI3K↓, *Akt↓, eff↑, ROS↑, Akt↑, Casp3↑,
1955- GamB,    Gambogic acid inhibits thioredoxin activity and induces ROS-mediated cell death in castration-resistant prostate cancer
- in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vitro, Pca, DU145
ROS↑, Apoptosis↑, Ferroptosis↑, Trx↓, eff↑, TrxR↓, Dose∅, MMP↓, eff↑, Casp↑, NADPH↓, TrxR↓, ChemoSen↑, AR↓,
2515- H2,    Recent Advances in Studies of Molecular Hydrogen against Sepsis
- Review, Sepsis, NA
*Sepsis↓, *Inflam↓, *antiOx↑, *ROS↓, *NADPH↓,
2508- H2,    Molecular hydrogen is a promising therapeutic agent for pulmonary disease
- Review, Var, NA - Review, Sepsis, NA
*ROS↓, eff↝, *Inflam↓, *NRF2↑, *HO-1↑, *SOD↑, *Catalase↑, *MPO↑, *ASK1↓, *NADPH↓, *Sepsis↓, *HMGB1↓, ROS↑, NLRP3↑, GSDMD↑, chemoP↑, eff↑,
3770- H2,    Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases
- Review, AD, NA - Review, Park, NA
*antiOx↑, *NRF2↑, *HO-1↑, *Inflam↓, *neuroP↑, *cardioP↑, *other↓, *ROS↓, *NADPH↓, *Catalase↑, *GPx1↑, *NO↓, *mt-ROS↓, *SIRT3↑, *SIRT1↑, *TLR4↓, *mTOR↓, *cognitive↑, *Sepsis↓, *PTEN↓, *Akt↓, *NLRP3↓, *AntiAg↑, *IL6↓, *TNF-α↓, *IL1β↓, *MDA↓, *memory↑, *FOXO3↑, TumCG↓, *LDL↓,
3773- H2,    Role and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases
- Review, Park, NA
*neuroP↑, *antiOx↑, *Inflam↓, *ROS↓, *NADPH↓, *NRF2↑, *BBB↑, *IL1β↓, *IL6↓, *TNF-α↓, *NF-kB↓, *NLRP3↓, *Sepsis↓, *p‑mTOR↓, *AMPK↑, *SIRT1↑, *HO-1↑,
2873- HNK,    Honokiol Alleviates Oxidative Stress-Induced Neurotoxicity via Activation of Nrf2
- in-vitro, Nor, PC12
*neuroP↑, *GSH↑, *HO-1↑, *NADPH↑, *Trx1↑, *TrxR1↑, *NRF2↑, *ROS↓, *antiOx↑, *BBB↑, Dose↓,
2868- HNK,    Honokiol: A review of its pharmacological potential and therapeutic insights
- Review, Var, NA - Review, Sepsis, NA
*P-gp↓, *ROS↓, *TNF-α↓, *IL10↓, *IL6↓, eIF2α↑, CHOP↑, GRP78/BiP↑, BAX↑, cl‑Casp9↑, p‑PERK↑, ER Stress↑, Apoptosis↑, MMPs↓, cFLIP↓, CXCR4↓, Twist↓, HDAC↓, BMPs↑, p‑STAT3↓, mTOR↓, EGFR↓, NF-kB↓, Shh↓, VEGF↓, tumCV↓, TumCMig↓, TumCI↓, ERK↓, Akt↓, Bcl-2↓, Nestin↓, CD133↓, p‑cMET↑, RAS↑, chemoP↑, *NRF2↑, *NADPH↓, *p‑Rac1↓, *ROS↓, *IKKα↑, *NF-kB↓, *COX2↓, *PGE2↓, *Casp3↓, *hepatoP↑, *antiOx↑, *GSH↑, *Catalase↑, *RenoP↑, *ALP↓, *AST↓, *ALAT↓, *neuroP↑, *cardioP↑, *HO-1↑, *Inflam↓,
2891- HNK,    Honokiol, an Active Compound of Magnolia Plant, Inhibits Growth, and Progression of Cancers of Different Organs
- Review, Var, NA
AntiCan↑, Inflam↓, antiOx↑, selectivity↑, *toxicity↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, TumMeta↓, NADPH↓, MMP2↓, MMP9↓, p‑mTOR↓, EGFR↓, EMT↓, SIRT1↑, SIRT3↑, EZH2↓, Snail↓, Vim↓, N-cadherin↓, E-cadherin↑, COX2↓, NF-kB↓, *ROS↓, Ca+2↑, ROS↑,
4209- Hup,    Huperzine A, reduces brain iron overload and alleviates cognitive deficit in mice exposed to chronic intermittent hypoxia
- in-vivo, NA, NA
*ROS↓, *cognitive↑, *neuroP↑, *Bax:Bcl2↓, *Casp3↑, *NADPH↓, *NOX↓, *TfR1/CD71↓, *Iron↓, *PSD95↑, *BDNF↑,
2540- M-Blu,    Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots
- Review, Var, NA - Review, AD, NA
*OCR↑, *Glycolysis↓, *GlucoseCon↑, neuroP↑, Warburg↓, mt-OXPHOS↑, TumCCA↑, TumCP↓, ROS⇅, *cognitive↑, *mTOR↓, *mt-antiOx↑, *memory↑, *BBB↑, *eff↝, *ECAR↓, eff↑, lactateProd↓, NADPH↓, OXPHOS↑, AMPK↑, selectivity↑,
5156- PTL,    Rational Design of a Parthenolide-based Drug Regimen That Selectively Eradicates Acute Myelogenous Leukemia Stem Cells
- in-vitro, AML, NA
NADPH↑, PPP↑, NRF2↑, ROS↑, CSCs↓, selectivity↑, other↝,
1985- PTL,    KEAP1 Is a Redox Sensitive Target That Arbitrates the Opposing Radiosensitive Effects of Parthenolide in Normal and Cancer Cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Nor, PrEC - in-vivo, NA, NA
ROS↑, NADPH↑, RadioS↑, radioP↑, Trx↓, *ox-Keap1↑, ox-Keap1↓, rd-Keap1↑, *NRF2↑, NRF2∅, NF-kB↓,
1987- PTL,  Rad,    A NADPH oxidase dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells
- in-vitro, Pca, PC3 - in-vitro, Nor, PrEC
selectivity↑, RadioS↑, ROS↑, *ROS∅, NADPH↑, Trx↓, PI3K↑, Akt↑, p‑FOXO3↓, SOD2↓, Catalase↓, radioP↑, *NADPH∅, *GSH↑, *GSH/GSSG↑, *NRF2↑,
3927- PTS,    Effects of Pterostilbene on Cardiovascular Health and Disease
- Review, AD, NA - Review, Stroke, NA
*Inflam↓, *antiOx↑, *BioAv↑, *toxicity↓, *NADPH↓, *ROS↓, *Catalase↑, *GSH↑, *SOD↑, *TNF-α↓, *IL1β↓, *IL4↓, *MMPs↓, *COX2↓, *MAPK↝, *NF-kB↓, *IL8↓, *MCP1↓, *E-sel↓, *lipid-P↓, *NRF2↑, *PPARα↑, *LDL↓, other↓,
3347- QC,    Recent Advances in Potential Health Benefits of Quercetin
- Review, Var, NA - Review, AD, NA
*antiOx↑, *ROS↓, *Inflam↓, TumCP↓, Apoptosis↑, *cardioP↑, *BP↓, TumMeta↓, MDR1↓, NADPH↓, ChemoSen↑, MMPs↓, TIMP2↑, *NLRP3↓, *IFN-γ↑, *COX2↓, *NF-kB↓, *MAPK↓, *CRP↓, *IL6↓, *TNF-α↓, *IL1β↓, *TLR4↑, *PKCδ↓, *AP-1↓, *ICAM-1↓, *NRF2↑, *HO-1↑, *lipid-P↓, *neuroP↑, *eff↑, *memory↑, *cognitive↑, *AChE↓, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑, *BioAv↑,
3336- QC,    Neuroprotective Effects of Quercetin in Alzheimer’s Disease
- Review, AD, NA
*neuroP↑, *lipid-P↓, *antiOx↑, *Aβ↓, *Inflam↓, *BBB↝, *NF-kB↓, *iNOS↓, *memory↑, *cognitive↑, *AChE↓, *MMP↑, *ROS↓, *ATP↑, *AMPK↑, *NADPH↓, *p‑tau↓,
3338- QC,    Quercetin: Its Antioxidant Mechanism, Antibacterial Properties and Potential Application in Prevention and Control of Toxipathy
- Review, Var, NA - Review, Stroke, NA
*antiOx↑, *GSH↑, *ROS↓, *Dose↑, *NADPH↓, *AMP↓, *NF-kB↓, *p38↑, *MAPK↑, *SOD↑, *MDA↓, *iNOS↓, *Catalase↑, *PI3K↑, *Akt↑, *lipid-P↓, *memory↑, *radioP↑, *neuroP↑, *MDA↓,
3079- RES,    Therapeutic role of resveratrol against hepatocellular carcinoma: A review on its molecular mechanisms of action
- Review, Var, NA
angioG↓, TumMeta↓, ChemoSen↑, NADPH↑, SIRT1↑, NF-kB↓, NLRP3↓, Dose↝, COX2↓, MMP9↓, PGE2↓, TIMP1↑, TIMP2↑, Sp1/3/4↓, p‑JNK↓, uPAR↓, ROS↓, CXCR4↓, IL6↓, Gli1↓, *ROS↓, *GSTs↑, *SOD↑, *Catalase↑, *GPx↑, *lipid-P↓, *GSH↑, eff↑, eff↑, eff↑,
3026- RosA,    Modulatory Effect of Rosmarinic Acid on H2O2-Induced Adaptive Glycolytic Response in Dermal Fibroblasts
- in-vitro, Nor, NA
*ROS↓, *ATP↑, *NADPH↓, *HK2↓, *PFK2↓, *LDHA↓, *GSR↑, *GPx↑, *Prx↑, *Trx↑, *antiOx↑, *GSH↑, *ROS↓, *GlucoseCon↓, *lactateProd↓, *Glycolysis↝, *ATP↑, *NADPH↓, *PPP↓,
4908- Sal,    Salinomycin triggers prostate cancer cell apoptosis by inducing oxidative and endoplasmic reticulum stress via suppressing Nrf2 signaling
- in-vitro, Pca, PC3 - in-vitro, Pca, DU145
tumCV↓, ROS↑, lipid-P↑, UPR↑, ER Stress↑, NRF2↓, NADPH↓, HO-1↓, SOD↓, Catalase↓, GPx↓, eff↓, TumCP↓,
3184- SFN,    The Integrative Role of Sulforaphane in Preventing Inflammation, Oxidative Stress and Fatigue: A Review of a Potential Protective Phytochemical
- Review, Nor, NA
*NRF2↑, *Inflam↓, *NF-kB↓, *ROS↓, *BioAv↝, *BioAv↝, *BioAv↝, *BioAv↝, *cardioP↑, *GPx↑, *SOD↑, *Catalase↑, *GPx↑, *HO-1↑, *NADPH↑, *NQO1↑, *LDH↓, *hepatoP↑, *ALAT↓, *AST↓, *IL6↓,
1429- SFN,    Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast
- in-vivo, Nor, NA - Human, Nor, NA
*NADPH↑, *NQO1↑, *HO-1↑, *Risk↑,
1431- SFN,    Induction of the phase 2 response in mouse and human skin by sulforaphane-containing broccoli sprout extracts
- in-vivo, Nor, NA
*NADPH↑, *NQO1↑, *GSTA1↑, *HO-1↑,
3309- SIL,    Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives
- Review, NA, NA
*ROS↓, *IronCh↑, *MMP↑, *NRF2↑, *Inflam↓, *hepatoP↑, *HSPs↑, *Trx↑, *SIRT2↑, *GSH↑, *ROS↑, *NADPH↓, *iNOS↓, *NF-kB↓, *BioAv↓, *Dose↝, *BioAv↑,
3310- SIL,    Silymarin attenuates paraquat-induced lung injury via Nrf2-mediated pathway in vivo and in vitro
- in-vitro, Lung, A549
Inflam↓, MPO↓, NO↓, iNOS↓, ROS↓, MDA↑, SOD↑, Catalase↑, GPx↑, NRF2↑, HO-1↑, NADPH↑,
964- SIL,    Silibinin inhibits hypoxia-induced HIF-1α-mediated signaling, angiogenesis and lipogenesis in prostate cancer cells: In vitro evidence and in vivo functional imaging and metabolomics
- vitro+vivo, Pca, LNCaP - in-vitro, Pca, 22Rv1
TumCP↓, Hif1a↓, NADPH↓, angioG↓, FASN↓, ACC↓,
5089- SSE,  Se,    Redox-mediated effects of selenium on apoptosis and cell cycle in the LNCaP human prostate cancer cell line
- in-vitro, Pca, LNCaP
ROS↑, mtDam↑, TumCD↑, Apoptosis↑, TumCCA↑, Trx↓, angioG↓, GSH⇅, NADPH↓, GPx↑,
5085- SSE,    Intravenous Infusion of High Dose Selenite in End-Stage Cancer Patients: Analysis of Systemic Exposure to Selenite and Seleno-Metabolites
- Review, Var, NA
toxicity↝, Half-Life↝, ROS↑, Thiols↓, NADPH↓, toxicity↝, other↝,
2128- TQ,    Thymoquinone inhibits phorbol ester-induced activation of NF-κB and expression of COX-2, and induces expression of cytoprotective enzymes in mouse skin in vivo
- in-vivo, NA, NA
*COX2↓, *NF-kB↓, *p‑Akt↓, *p‑cJun↓, *p‑p38↓, *HO-1↑, *NADPH↑, *GSTA1↑, *antiOx↑, *Inflam↓, *NQO1↑, *GCLC↑, *GSTA1↑,
3431- TQ,    PI3K-AKT Pathway Modulation by Thymoquinone Limits Tumor Growth and Glycolytic Metabolism in Colorectal Cancer
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW48
Glycolysis↓, Warburg↓, HK2↓, ATP↓, NADPH↓, PI3K↓, Akt↓, TumCP↓, E-cadherin↑, N-cadherin↓, Hif1a↓, PKM2↓, GlucoseCon↓, lactateProd↓, EMT↓,
4314- VitB1/Thiamine,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*Risk↓, *GlucoseCon↑, *cognitive↑, *ATP↑, *ROS↓, *NADPH↑, *Aβ↓, *APP↓, *BACE↓,
4031- VitB3,    Nicotinamide Riboside-The Current State of Research and Therapeutic Uses
- Review, NA, NA
*cardioP↑, *neuroP↑, *NAD↑, *SIRT1↑, *NADPH↑, *ROS↓, *IL2↓, *IL5↓, *IL6↓, *TNF-α↓, *Inflam↓, *BioAv↝, *BioAv↑,
4330- VitB5,    Metabolic changes and inflammation in cultured astrocytes from the 5xFAD mouse model of Alzheimer’s disease: Alleviation by pantethine
- in-vivo, AD, NA
*neuroP↑, *Inflam↓, *ATP↑, *G6PD↑, *NADPH↑, *IL1β↓, *other↝,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 50

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   ATF3↑, 1,   Catalase↓, 4,   Catalase↑, 1,   Fenton↑, 1,   Ferroptosis↑, 2,   frataxin↑, 1,   GPx↓, 2,   GPx↑, 2,   GPx4↓, 1,   GSH↓, 4,   GSH⇅, 1,   GSR↑, 1,   HK1↓, 1,   HO-1↓, 2,   HO-1↑, 2,   ox-Keap1↓, 1,   rd-Keap1↑, 1,   lipid-P↑, 2,   MDA↑, 1,   MPO↓, 1,   NQO1↑, 1,   NRF2↓, 4,   NRF2↑, 4,   NRF2∅, 1,   OXPHOS↑, 1,   OXPHOS↝, 1,   mt-OXPHOS↑, 1,   ROS↓, 2,   ROS↑, 24,   ROS⇅, 1,   mt-ROS↑, 1,   SIRT3↑, 2,   SOD↓, 3,   SOD↑, 1,   SOD1↓, 1,   SOD2↓, 1,   Thiols↓, 1,   Trx↓, 4,   TrxR↓, 2,  

Metal & Cofactor Biology ⓘ

Ferritin↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 5,   CDC2↓, 1,   mitResp↓, 1,   MMP↓, 3,   MMP↑, 1,   mtDam↑, 2,   p42↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

ACC↓, 1,   ACLY↓, 1,   adiP↑, 1,   ALDOA↓, 1,   AMPK↑, 4,   cMyc↓, 2,   ENO1↓, 1,   FASN↓, 2,   GLO-I↓, 1,   GLS↓, 1,   GlucoseCon↓, 1,   glyC↓, 1,   Glycolysis↓, 6,   HK2↓, 5,   lactateProd↓, 4,   LDH↓, 1,   LDHA↓, 1,   NADPH↓, 18,   NADPH↑, 8,   NADPH↝, 1,   PDH↓, 1,   PFK↓, 1,   PGK1↓, 1,   PI3K/Akt↓, 1,   PKM2↓, 2,   PPP↓, 2,   PPP↑, 1,   SIRT1↓, 1,   SIRT1↑, 2,   Warburg↓, 2,  

Cell Death ⓘ

Akt↓, 6,   Akt↑, 2,   p‑Akt↓, 1,   Apoptosis↑, 10,   BAX↓, 1,   BAX↑, 3,   Bax:Bcl2↑, 2,   Bcl-2↓, 5,   Bcl-xL↓, 1,   Casp↑, 2,   Casp12↑, 1,   Casp3↑, 7,   cl‑Casp3↑, 2,   Casp9↑, 4,   cl‑Casp9↑, 2,   cFLIP↓, 1,   Chk2↓, 1,   CK2↓, 1,   Cyt‑c↑, 3,   Ferroptosis↑, 2,   GSDMD↑, 1,   HEY1↓, 1,   iNOS↓, 1,   JNK↑, 2,   p‑JNK↓, 1,   MAPK↑, 1,   Mcl-1↓, 2,   p27↑, 1,   p38↑, 3,   survivin↓, 2,   Telomerase↓, 1,   TumCD↑, 3,  

Kinase & Signal Transduction ⓘ

HER2/EBBR2↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics ⓘ

EZH2↓, 1,   H3↑, 1,   other↓, 2,   other↝, 3,   tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

CHOP↑, 2,   eIF2α↑, 1,   ER Stress↑, 4,   GRP78/BiP↑, 1,   HSP90↓, 1,   p‑PERK↑, 1,   UPR↑, 1,  

Autophagy & Lysosomes ⓘ

LC3II↑, 1,   p62↓, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

CHK1↓, 1,   DNAdam↑, 1,   MGMT↓, 1,   p16↑, 1,   P53↑, 3,   PARP↑, 1,   cl‑PARP↑, 3,   γH2AX↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK2↓, 4,   CDK4↓, 5,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 5,   CycD3↓, 1,   cycE/CCNE↓, 2,   P21↑, 2,   p‑RB1↓, 1,   TumCCA↑, 7,  

Proliferation, Differentiation & Cell State ⓘ

CD133↓, 1,   p‑cMET↑, 1,   CSCs↓, 4,   EMT↓, 5,   ERK↓, 2,   FOXO3↑, 3,   p‑FOXO3↓, 1,   Gli↓, 1,   Gli1↓, 1,   GSK‐3β↓, 1,   HDAC↓, 2,   HDAC1↓, 1,   HDAC3↓, 1,   HDAC8↓, 1,   IGF-1↓, 2,   IGFBP1↑, 1,   mTOR↓, 2,   p‑mTOR↓, 1,   Nestin↓, 1,   NOTCH↓, 1,   PI3K↓, 2,   PI3K↑, 1,   RAS↑, 1,   SCF↓, 1,   Shh↓, 1,   STAT3↓, 5,   p‑STAT3↓, 1,   TumCG↓, 3,   Wnt↓, 1,  

Migration ⓘ

5LO↓, 1,   AP-1↓, 1,   Ca+2↑, 3,   E-cadherin↑, 5,   ER-α36↓, 1,   FAK↓, 2,   ITGB1↓, 1,   ITGB3↓, 1,   MMP2↓, 5,   MMP9↓, 6,   MMPs↓, 5,   N-cadherin↓, 3,   Slug↓, 1,   Snail↓, 3,   TIMP1↑, 1,   TIMP2↑, 2,   TumCI↓, 3,   TumCMig↓, 2,   TumCP↓, 6,   TumMeta↓, 3,   TumMeta↑, 1,   Twist↓, 2,   uPA↓, 3,   uPAR↓, 1,   Vim↓, 3,   Zeb1↓, 1,   β-catenin/ZEB1↓, 3,  

Angiogenesis & Vasculature ⓘ

angioG↓, 7,   ATF4↑, 1,   EGFR↓, 2,   Hif1a↓, 6,   NO↓, 1,   PDGFR-BB↓, 1,   VEGF↓, 5,  

Barriers & Transport ⓘ

GLUT1↓, 3,   GLUT3↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 5,   CXCR4↓, 2,   IL6↓, 2,   IL8↓, 2,   Inflam↓, 3,   NF-kB↓, 9,   PGE2↓, 1,  

Protein Aggregation ⓘ

NLRP3↓, 1,   NLRP3↑, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,   CDK6↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioAv↝, 1,   BioEnh↑, 1,   ChemoSen↑, 9,   Dose↓, 1,   Dose↝, 2,   Dose∅, 1,   eff↓, 4,   eff↑, 15,   eff↝, 3,   Half-Life↓, 2,   Half-Life↝, 1,   MDR1↓, 1,   RadioS↑, 4,   selectivity↑, 7,  

Clinical Biomarkers ⓘ

AR↓, 1,   BMPs↑, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 2,   EZH2↓, 1,   Ferritin↓, 1,   HER2/EBBR2↓, 1,   IL6↓, 2,   LDH↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 4,   chemoP↑, 3,   chemoPv↑, 3,   ChemoSideEff↓, 1,   neuroP↑, 1,   radioP↑, 3,   RenoP↑, 1,   toxicity↑, 1,   toxicity↝, 2,  
Total Targets: 257

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 15,   mt-antiOx↑, 1,   Catalase↑, 8,   GCLC↑, 1,   GPx↑, 5,   GPx1↑, 1,   GSH↑, 11,   GSH/GSSG↑, 1,   GSR↑, 2,   GSTA1↑, 3,   GSTs↑, 3,   HO-1↑, 12,   Iron↓, 1,   ox-Keap1↑, 1,   lipid-P↓, 7,   MDA↓, 3,   MPO↓, 1,   MPO↑, 1,   NQO1↑, 6,   NRF2↑, 13,   Prx↑, 2,   ROS↓, 24,   ROS↑, 1,   ROS∅, 1,   mt-ROS↓, 1,   SIRT3↑, 1,   SOD↑, 6,   SOD2↑, 1,   Trx↑, 2,   Trx1↑, 1,   TrxR1↑, 1,  

Metal & Cofactor Biology ⓘ

IronCh↑, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↑, 5,   MMP↑, 2,   OCR↑, 1,  

Core Metabolism/Glycolysis ⓘ

ACC↑, 1,   ALAT↓, 2,   AMP↓, 1,   AMPK↑, 3,   ECAR↓, 1,   G6PD↑, 1,   GlucoseCon↓, 1,   GlucoseCon↑, 3,   Glycolysis↓, 1,   Glycolysis↝, 1,   HK2↓, 1,   lactateProd↓, 1,   LDH↓, 1,   LDHA↓, 1,   LDL↓, 3,   NAD↑, 1,   NADPH↓, 13,   NADPH↑, 11,   NADPH∅, 1,   PFK2↓, 1,   PPARα↑, 1,   PPP↓, 1,   SIRT1↑, 4,   SIRT2↑, 1,  

Cell Death ⓘ

Akt↓, 3,   Akt↑, 1,   p‑Akt↓, 1,   ASK1↓, 1,   Bax:Bcl2↓, 1,   Casp3?, 1,   Casp3↓, 1,   Casp3↑, 1,   iNOS↓, 4,   MAPK↓, 2,   MAPK↑, 1,   MAPK↝, 1,   p38↑, 1,   p‑p38↓, 1,  

Transcription & Epigenetics ⓘ

p‑cJun↓, 1,   other↓, 1,   other↝, 1,  

Protein Folding & ER Stress ⓘ

HSPs↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

FOXO3↑, 1,   GSK‐3β↓, 1,   mTOR↓, 3,   p‑mTOR↓, 1,   p300↓, 1,   PI3K↓, 1,   PI3K↑, 1,   PTEN↓, 1,   RAS↓, 1,   STAT3↓, 1,  

Migration ⓘ

AntiAg↑, 1,   AP-1↓, 1,   APP↓, 1,   CDK5↓, 1,   E-sel↓, 1,   MMPs↓, 1,   PKCδ↓, 1,   p‑Rac1↓, 1,   TXNIP↓, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Barriers & Transport ⓘ

BBB↑, 4,   BBB↝, 1,   P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX2↓, 6,   CRP↓, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↑, 1,   IKKα↑, 1,   IL10↓, 1,   IL10↑, 1,   IL17↓, 1,   IL1β↓, 6,   IL2↓, 1,   IL23↓, 1,   IL4↓, 1,   IL5↓, 1,   IL6↓, 6,   IL8↓, 1,   Inflam↓, 16,   MCP1↓, 2,   NF-kB↓, 12,   PGE2↓, 1,   TLR4↓, 1,   TLR4↑, 1,   TNF-α↓, 7,  

Cellular Microenvironment ⓘ

NOX↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 4,   BDNF↑, 2,   PSD95↑, 1,   p‑tau↓, 2,  

Protein Aggregation ⓘ

Aβ↓, 4,   BACE↓, 2,   NLRP3↓, 4,  

Drug Metabolism & Resistance ⓘ

BioAv↓, 2,   BioAv↑, 8,   BioAv↝, 5,   Dose↑, 1,   Dose↝, 1,   eff↑, 1,   eff↝, 1,  

Clinical Biomarkers ⓘ

ALAT↓, 2,   ALP↓, 1,   AST↓, 2,   BP↓, 1,   CRP↓, 1,   IL6↓, 6,   LDH↓, 1,  

Functional Outcomes ⓘ

AntiAge↑, 1,   cardioP↑, 5,   cognitive↑, 7,   hepatoP↑, 3,   memory↑, 7,   neuroP↑, 11,   OS↑, 1,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 1,   Risk↑, 1,   toxicity↓, 4,  

Infection & Microbiome ⓘ

Sepsis↓, 4,  
Total Targets: 159

Scientific Paper Hit Count for: NADPH, Nicotinamide adenine dinucleotide phosphate
4 Hydrogen Gas
3 Curcumin
3 Honokiol
3 Parthenolide
3 Quercetin
3 Sulforaphane (mainly Broccoli)
3 Silymarin (Milk Thistle) silibinin
2 Alpha-Lipoic-Acid
2 Apigenin (mainly Parsley)
2 Chrysin
2 Radiotherapy/Radiation
2 Selenite (Sodium)
2 Thymoquinone
1 2-DeoxyGlucose
1 3-bromopyruvate
1 Artemisinin
1 Ashwagandha(Withaferin A)
1 Boswellia (frankincense)
1 Caffeic acid
1 Metformin
1 Capsaicin
1 Chemotherapy
1 diet FMD Fasting Mimicking Diet
1 Gambogic Acid
1 Huperzine A/Huperzia serrata
1 Methylene blue
1 Pterostilbene
1 Resveratrol
1 Rosmarinic acid
1 salinomycin
1 Selenium
1 Vitamin B1/Thiamine
1 Vitamin B3,Niacin
1 Vitamin B5,Pantothenic Acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:624  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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