Database Query Results : , , PTP1B

PTP1B, protein tyrosine phosphatase 1B: Click to Expand ⟱
Source:
Type:
PTP1B (protein tyrosine phosphatase 1B) is a protein that has been linked to the development and progression of certain types of cancer. It plays a role in regulating insulin signaling, and dysregulation of this pathway can contribute to cancer cell growth and survival.
In cancer cells, PTP1B has been shown to promote processes such as epithelial-mesenchymal transition (EMT), which allows cancer cells to become more invasive and metastatic.
PTP1B inhibitors have been shown to reduce tumor growth and metastasis in various cancer models.
In general, PTP1B expression is upregulated in cancer cells, which can contribute to cancer progression and resistance to therapy.
Scientific Papers found: Click to Expand⟱
412- CUR,    Curcumin and Its New Derivatives: Correlation between Cytotoxicity against Breast Cancer Cell Lines, Degradation of PTP1B Phosphatase and ROS Generation
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
ROS↑, PTP1B↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Migration ⓘ

PTP1B↓, 1,  
Total Targets: 2

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PTP1B, protein tyrosine phosphatase 1B
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:641  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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