Database Query Results : , , GPx4

GPx4, Glutathione Peroxidase 4: Click to Expand ⟱

Source:

Type:

GPX4 (Glutathione Peroxidase 4) is a selenoprotein that plays a crucial role in the regulation of ferroptosis, a form of programmed cell death characterized by the iron-dependent accumulation of lipid reactive oxygen species (ROS).
GPX4 has been found to be upregulated in several tumor types, promoting cancer cell survival and resistance to therapy. For instance, GPX4 overexpression has been observed in renal cell carcinoma, pancreatic ductal adenocarcinoma, and triple-negative breast cancer, among others. -GPX4 is known as a lipid peroxidation inhibitor protein, and its antioxidant effect is closely related to ferrous iron

Scientific Papers found: Click to Expand⟱

5458-

AF,

Auranofin reveals therapeutic anticancer potential by triggering distinct molecular cell death mechanisms and innate immunity in mutant p53 non-small cell lung cancer

in-vitro,

NSCLC,

TrxR↓, AntiCan↓, GPx4↓, DNAdam↑, toxicity↓, eff↝,

5431-

AG,

Advances in research on the anti-tumor mechanism of Astragalus polysaccharides

Review,

Var,

AntiTum↑, TumCG↓, TumCI↓, Apoptosis↑, Imm↑, Bcl-2↓, BAX↑, Wnt↓, β-catenin/ZEB1↓, TumCG↓, miR-133a-3p↑, JNK↓, Fas↑, P53↑, P21↑, NOTCH1↓, NOTCH3↓, TumCP↓, TumCCA↑, GPx4↓, xCT↓, AMPK↑, Beclin-1↑, NF-kB↓, EMT↓, Vim↓, TumMeta↓, VEGF↓, EGFR↓, eff↑, eff↑, MMP↓, P-gp↓, MMP9↓, ChemoSen↑, SIRT1↓, SREBP1↓, TumAuto↑, PI3K↓, mTOR↓, Casp3↑, Casp9↑, CD133↓, CD44↓, CSCs↓, QoL↑,

5434-

AG,

Recent Advances in the Mechanisms and Applications of Astragalus Polysaccharides in Liver Cancer Treatment: An Overview

Review,

Liver,

AntiCan↑, Apoptosis↑, TumCP↓, EMT↓, Imm↑, ChemoSen↑, BioAv↓, TumCG↓, IL2↑, IL12↑, TNF-α↑, P-gp↓, MDR1↓, QoL↑, Casp↑, DNAdam↑, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, NOTCH1↓, GSK‐3β↓, TumCCA↑, GSH↓, ROS↑, lipid-P↑, c-Iron↑, GPx4↓, ACSL4↑, Ferroptosis↑, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, Akt↓, PI3K↓, mTOR↓, CXCR4↓, Vim↓, PD-L1↓, eff↑, eff↑, ChemoSen↑, ChemoSen↑, chemoP↑,

4558-

AgNPs,

Role of Oxidative and Nitro-Oxidative Damage in Silver Nanoparticles Cytotoxic Effect against Human Pancreatic Ductal Adenocarcinoma Cells

in-vitro,

PC,

PANC1

3.19 ug/mL

ROS↑, selectivity↑, NO↑, SOD↓, GPx4↓, Catalase↓, TumCCA↑, MMP↓,

1349-

And,

Andrographolide promoted ferroptosis to repress the development of non-small cell lung cancer through activation of the mitochondrial dysfunction

in-vitro,

Lung,

H460

33.16 μM

in-vitro,

Lung,

H1650

32.45 μM

TumCG↓, TumMeta↓, Ferroptosis↑, ROS↑, MDA↑, Iron↑, GSH↓, GPx4↓, xCT↓, MMP↓, ATP↓,

3382-

ART/DHA,

Repurposing Artemisinin and its Derivatives as Anticancer Drugs: A Chance or Challenge?

Review,

Var,

1.20–15.2 μM

AntiCan↑, toxicity↑, Ferroptosis↑, ROS↑, TumCCA↑, BioAv↝, eff↝, Half-Life↓, Ferritin↓, GPx4↓, NADPH↓, GSH↓, BAX↑, Cyt‑c↑, cl‑Casp3↑, VEGF↓, IL8↓, COX2↓, MMP9↓, E-cadherin↑, MMP2↓, NF-kB↓, p16↑, CDK4↓, cycD1/CCND1↓, p62↓, LC3II↑, EMT↓, CSCs↓, Wnt↓, β-catenin/ZEB1↓, uPA↓, TumAuto↑, angioG↓, ChemoSen↑,

3384-

ART/DHA,

Dihydroartemisinin triggers ferroptosis in primary liver cancer cells by promoting and unfolded protein response‑induced upregulation of CHAC1 expression

in-vitro,

Liver,

Hep3B

29.4±1.7 µM

in-vitro,

Liver,

HUH7

32.1±4.5 µM

in-vitro,

Liver,

HepG2

40.2±2.1 µM

Ferroptosis↑, ROS↑, GSH↓, UPR↑, GPx4↓, PERK↑, eIF2α↑, ATF4↑,

3387-

ART/DHA,

Ferroptosis: A New Research Direction of Artemisinin and Its Derivatives in Anti-Cancer Treatment

Review,

Var,

BioAv↓, lipid-P↑, Ferroptosis↑, Iron↑, GPx4↓, GSH↓, P53↑, ER Stress↑, PERK↑, ATF4↑, GRP78/BiP↑, CHOP↑, ROS↑, NRF2↑,

3345-

ART/DHA,

Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells

in-vitro,

GBM,

ROS↑, Ferroptosis↑, lipid-P↑, HSP70/HSPA5↑, ER Stress↑, ATF4↑, GRP78/BiP↑, MDA↑, GSH↓, eff↑, GPx4↑,

2575-

ART/DHA,

docx,

Artemisia santolinifolia-Mediated Chemosensitization via Activation of Distinct Cell Death Modes and Suppression of STAT3/Survivin-Signaling Pathways in NSCLC

in-vitro,

Lung,

H23

AS at concentrations of 100 and 200 μg/mL in combination with DTX at concentrations of 0.5, 1 and 2.5 nM for 48 h.

ChemoSen↑, GPx4↓, ROS↑, Ferroptosis↑, eff↑,

5378-

ART/DHA,

Natural Agents Modulating Ferroptosis in Cancer: Molecular Pathways and Therapeutic Perspectives

Review,

Var,

Ferroptosis↑, Iron↑, lipid-P↑, MOMP↑, AntiCan↑, NCOA4↑, GSH↓, GPx4↓, ROS↑, ChemoSen↑, ER Stress↑, DNAdam↑, angioG↓, TumCCA↑, eff↓,

575-

ART/DHA,

Dihydroartemisinin initiates ferroptosis in glioblastoma through GPX4 inhibition

in-vitro,

GBM,

U87MG

GPx4↓, xCT∅, ROS↑, Ferroptosis↑, ACSL4∅,

3173-

Ash,

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

in-vitro,

neuroblastoma,

GPx4↓, HO-1↑, lipid-P↑, Keap1↓, NRF2↑, Ferroptosis↑,

3156-

Ash,

Withaferin A: From ayurvedic folk medicine to preclinical anti-cancer drug

Review,

Var,

MAPK↑, p38↑, BAX↑, BIM↑, CHOP↑, ROS↑, DR5↑, Apoptosis↑, Ferroptosis↑, GPx4↓, BioAv↝, HSP90↓, RET↓, E6↓, E7↓, Akt↓, cMET↓, Glycolysis↓, TCA↓, NOTCH1↓, STAT3↓, AP-1↓, PI3K↓, eIF2α↓, HO-1↑, TumCCA↑, CDK1↓, *hepatoP↑, *GSH↑, *NRF2↑, Wnt↓, EMT↓, uPA↓, CSCs↓, Nanog↓, SOX2↓, CD44↓, lactateProd↓, Iron↑, NF-kB↓,

4822-

ASTX,

Rad,

Astaxanthin Synergizes with Ionizing Radiation (IR) in Oral Squamous Cell Carcinoma (OSCC)

tumCV↓, selectivity↑, RadioS↑, GPx4↓, Ferroptosis↑,

2475-

Ba,

Baicalein triggers ferroptosis in colorectal cancer cells via blocking the JAK2/STAT3/GPX4 axis

in-vitro,

CRC,

HCT116

in-vitro,

CRC,

DLD1

in-vivo,

NA,

(10, 20 mg/kg, i.g., every two days for two weeks)

CRC xenograft mouse model,

tumCV↓, GPx4↓, STAT3↓, Ferroptosis↑,

2625-

Ba,

LT,

Baicalein and luteolin inhibit ischemia/reperfusion-induced ferroptosis in rat cardiomyocyte

in-vivo,

Stroke,

rat

*lipid-P↓, *ACSL4∅, *NRF2∅, *GPx4∅, *Ferroptosis↓, *ROS↓, *MDA↓, *eff↑, *HO-1∅,

2296-

Ba,

The most recent progress of baicalein in its anti-neoplastic effects and mechanisms

Review,

Var,

CDK1↓, Cyc↓, p27↑, P21↑, P53↑, TumCCA↑, TumCI↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Vim↓, LC3A↑, p62↓, p‑mTOR↓, PD-L1↓, CAFs/TAFs↓, VEGF↓, ROCK1↓, Bcl-2↓, Bcl-xL↓, BAX↑, ROS↑, cl‑PARP↑, Casp3↑, Casp9↑, PTEN↑, MMP↓, Cyt‑c↑, Ca+2↑, PERK↑, IRE1↑, CHOP↑, Copper↑, Snail↓, Vim↓, Twist↓, GSH↓, NRF2↓, HO-1↓, GPx4↓, XIAP↓, survivin↓, DR5↑,

2756-

BetA,

Betulinic acid inhibits growth of hepatoma cells through activating the NCOA4-mediated ferritinophagy pathway

in-vitro,

HCC,

HUH7

10 μM was selected as a low dose (BETL group), 20 μM as a medium dose (BETM group) and 40 μM as a high dose (BETH group)

in-vitro,

HCC,

H1299

TumCP↓, ROS↓, antiOx↓, TumCG↓, TumCMig↓, NRF2↓, GPx4↓, HO-1↓, NCOA4↑, FTH1↓, Ferritin↑, Ferroptosis↑, GSH↓, MDA↓,

739-

Bor,

Borax regulates iron chaperone- and autophagy-mediated ferroptosis pathway in glioblastoma cells

in-vitro,

GBM,

U87MG

in-vitro,

Nor,

HMC3

this report calls HMC3 "normal cells"

TumCG↓, TumCP↓, TumCCA↑, PCBP1↓, GSH↓, GPx4↓, Beclin-1↑, MDA↑, ACSL4↑, Casp3↑, Casp7↑, Ferroptosis↑, *toxicity↓,

738-

Bor,

Borax induces ferroptosis of glioblastoma by targeting HSPA5/NRF2/GPx4/GSH pathways

in-vitro,

GBM,

U251

in-vitro,

GBM,

A172

in-vitro,

Nor,

SVGp12

TumCP↓, GPx4↓, GSH↓, HSP70/HSPA5↓, NRF2↓, MDA↑, Casp3↑, Casp7↑, Ferroptosis↑, selectivity↑,

1447-

Bos,

Boswellia carterii n-hexane extract suppresses breast cancer growth via induction of ferroptosis by downregulated GPX4 and upregulated transferrin

in-vitro,

BC,

MDA-MB-231

1-100uM BCHE

in-vitro,

BC,

MCF-7

in-vivo,

BC,

4T1

400-800 mg/kg

mouse BC 4T1

in-vitro,

Nor,

MCF10

tumCV↓, AntiCan↑, *toxicity↓, Ferroptosis↑, i-Iron↑, GPx4↓, ROS↑, lipid-P↑, Tf↑, TumCG↓,

1585-

Citrate,

Sodium citrate targeting Ca2+/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer

in-vitro,

Ovarian,

SKOV3

15.93 mM

in-vitro,

Ovarian,

A2780S

16.8 mM

in-vitro,

Nor,

HEK293

Apoptosis↑, Ferroptosis↑, Ca+2↓, CaMKII ↓, Akt↓, mTOR↓, Hif1a↓, ROS↑, ChemoSen↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, Cyt‑c↑, GlucoseCon↓, lactateProd↓, Pyruv↓, GLUT1↓, HK2↓, PFKP↓, Glycolysis↓, Hif1a↓, p‑Akt↓, p‑mTOR↓, Iron↑, lipid-P↑, MDA↑, ROS↑, H2O2↑, mtDam↑, GSH↓, GPx↓, GPx4↓, NADPH/NADP+↓, eff↓, FTH1↓, LC3‑Ⅱ/LC3‑Ⅰ↑, NCOA4↑, eff↓, TumCG↓,

1410-

CUR,

Curcumin induces ferroptosis and apoptosis in osteosarcoma cells by regulating Nrf2/GPX4 signaling pathway

vitro+vivo,

OS,

MG63

tumCV↓, Apoptosis↑, TumCG↓, NRF2↓, GPx4↓, HO-1↓, xCT↓, ROS↑, MDA↑, GSH↓,

414-

CUR,

Transcriptome Investigation and In Vitro Verification of Curcumin-Induced HO-1 as a Feature of Ferroptosis in Breast Cancer Cells

in-vitro,

BC,

MCF-7

114 μM

in-vitro,

BC,

MDA-MB-231

Ferroptosis↑, Iron↑, ROS↑, lipid-P↑, MDA↑, GSH↓, HO-1↑, NRF2↑, GPx↓, ROS↑, Iron↑, GPx4↓, HSP70/HSPA5↑, ATFs↑, CHOP↑, MDA↑, FTL↑, FTH1↑, BACH1↑, REL↑, USF1↑, NFE2L2↑,

448-

CUR,

Heat shock protein 27 influences the anti-cancer effect of curcumin in colon cancer cells through ROS production and autophagy activation

in-vitro,

CRC,

HT-29

15, 20 and 25 μM, 48 h

Apoptosis↑, TumCCA↑, p‑Akt↓, Akt↓, Bcl-2↓, p‑BAD↓, BAD↑, cl‑PARP↑, ROS↑, HSP27↑, Beclin-1↑, p62↑, GPx1↓, GPx4↓,

3215-

EGCG,

Epigallocatechin gallate modulates ferroptosis through downregulation of tsRNA-13502 in non-small cell lung cancer

in-vitro,

NSCLC,

A549

 111.1 μM

in-vitro,

NSCLC,

H1299

 5.564 μM

TumCP↓, Ki-67↓, GPx4↓, ACSL4↑, Iron↑, MDA↑, ROS↑, Ferroptosis↑, eff↑, NRF2↑, HO-1↑,

2204-

erastin,

Regulation of ferroptotic cancer cell death by GPX4

in-vitro,

fibroS,

HT1080

GSH↓, Ferroptosis↑, ROS↑, GPx↓, GPx4↓, lipid-P↑, eff↓, eff↑,

2082-

HNK,

Revealing the role of honokiol in human glioma cells by RNA-seq analysis

in-vitro,

GBM,

U87MG

36.27 μM

In U87-MG cells, the optimum concentration of honokiol was 20 µM, and the optimum time was 48 h

in-vitro,

GBM,

U251

59.53 μM

n U251-MG cells, the optimum concentration of honokiol was 40 µM, and the optimum time was 48 h

AntiCan↑, TumCP↑, TumAuto↑, Apoptosis↑, *BioAv↑, *neuroP↑, *NF-kB↑, MAPK↑, GPx4↑, Tf↑, BAX↑, Bcl-2↓, antiOx↑, Hif1a↓, Ferroptosis↑,

2080-

HNK,

Honokiol Induces Ferroptosis by Upregulating HMOX1 in Acute Myeloid Leukemia Cells

in-vitro,

AML,

THP1

20 μM

in-vitro,

AML,

U937

35 μM

in-vitro,

AML,

SK-HEP-1

30 μM

tumCV↓, TumCCA↑, Ferroptosis↑, lipid-P↑, HO-1↑, GPx4∅,

2081-

HNK,

Honokiol induces ferroptosis in colon cancer cells by regulating GPX4 activity

in-vitro,

Colon,

RKO

11.42 μM

in-vitro,

Colon,

HCT116

47.65 μM

in-vitro,

Colon,

SW48

in-vitro,

Colon,

HT-29

in-vitro,

Colon,

LS174T

in-vitro,

Colon,

HCT8

in-vitro,

Colon,

SW480

in-vivo,

NA,

mice

tumCV↓, ROS↑, Iron↑, GPx4↓, mtDam↑, Ferroptosis↑, TumVol↓, TumW↓,

4641-

HT,

Hydroxytyrosol induced ferroptosis through Nrf2 signaling pathway in colorectal cancer cells

in-vitro,

CRC,

HCT116

in-vitro,

CRC,

SW48

Ferroptosis↑, Iron↑, lipid-P↑, ROS↑, GSH↓, MMP↓, GPx4↓, TLR1↑, eff↓, NRF2↓, ROS↑,

1924-

JG,

Juglone triggers apoptosis of non-small cell lung cancer through the reactive oxygen species -mediated PI3K/Akt pathway

in-vitro,

Lung,

A549

2-8uM

9.47 μM@24h

TumCMig↓, TumCI↓, TumCCA↑, Apoptosis↑, cl‑Casp3↑, BAX↑, Cyt‑c↑, ROS↑, MDA↑, GPx4↓, SOD↓, PI3K↓, Akt↓, eff↓,

5099-

JG,

Juglone induces ferroptosis in glioblastoma cells by inhibiting the Nrf2-GPX4 axis through the phosphorylation of p38MAPK

vitro+vivo,

GBM,

LN229

 juglone (1 mg/kg),  intraperitoneal injection

9.214 μM (72 h)

GBM xenograft nude mice model

vitro+vivo,

GBM,

T98G

 23.45 μM (72 h) in T98G

Ferroptosis↑, p‑MAPK↑, NRF2↓, GPx4↓, TumPF↓, Apoptosis↑, ROS↑, GSH↓, lipid-P↑, Ki-67↓, TumCG↓,

1275-

LT,

Mechanism of luteolin induces ferroptosis in nasopharyngeal carcinoma cells

in-vitro,

Laryn,

Ferroptosis↑, MDA↑, Iron↑, SOD↓, GSH↓, GPx4↓, SOX4↓, GDF15↓,

1204-

MET,

Metformin induces ferroptosis through the Nrf2/HO-1 signaling in lung cancer

in-vitro,

Lung,

A549

in-vitro,

Lung,

H1299

MDA↑, ROS↑, Iron↑, GSH↓, T-SOD↓, Catalase↓, GPx4↓, xCT↓, NRF2↓, HO-1↓,

2249-

MF,

Pulsed electromagnetic fields modulate energy metabolism during wound healing process: an in vitro model study

in-vitro,

Nor,

L929

4mT, 80 Hz

 pulsed burst (burst width, 2 ms; pulse width, 10.5 ms).

*TumCMig↑, *tumCV↑, *Glycolysis↑, *ROS↓, *mitResp↓, *other↝, *OXPHOS↓, *pH↑, *antiOx↑, *PFKM↑, *PFKL↑, *PKM2↑, *HK2↑, *GLUT1↑, *GPx1↑, *GPx4↑, *SOD1↑,

582-

MF,

immuno,

VitC,

Magnetic field boosted ferroptosis-like cell death and responsive MRI using hybrid vesicles for cancer immunotherapy

in-vitro,

Pca,

TRAMP-C1

As shown in Fig. 1a, once AA is released under the MF, ferric ions in IONCs are reduced by AA increasing ferrous ions, which are a stronger inducer for Fenton reaction compared with ferric ions

in-vivo,

NA,

TRAMP-C1 tumor-bearing mice

Fenton↑, Ferroptosis↑, ROS↑, TumCG↓, Iron↑, GPx4↓,

525-

MF,

Pulsed electromagnetic fields regulate metabolic reprogramming and mitochondrial fission in endothelial cells for angiogenesis

in-vitro,

Nor,

HUVECs

4mT,  80 Hz

*angioG↑, *GPx1↑, *GPx4↑, *SOD↑, *PFKM↑, *PFKL↑, *PKM2↑, *PFKP↑, *HK2↑, *GLUT1↑, *GLUT4↑, *ROS↓, *MMP↝, *Glycolysis↑, *OXPHOS↓,

4102-

MF,

Modulation of antioxidant enzyme gene expression by extremely low frequency electromagnetic field in post-stroke patients

Human,

Stroke,

40 Hz frequency at 7 milliTesla, for 15 minutes per day, five days a week, over a four‑week

 Forty-eight post-stroke patients

*Catalase↑, *SOD1↑, *SOD2↑, *GPx1↑, *GPx4↑, *Dose↝,

3457-

MF,

Cellular stress response to extremely low‐frequency electromagnetic fields (ELF‐EMF): An explanation for controversial effects of ELF‐EMF on apoptosis

Review,

Var,

Apoptosis↑, H2O2↑, ROS↑, eff↑, eff↑, Ca+2↑, MAPK↑, *Catalase↑, *SOD1↑, *GPx1↑, *GPx4↑, *NRF2↑, TumAuto↑, ER Stress↑, HSPs↑, SIRT3↑, ChemoSen↑, UPR↑, other↑, PI3K↓, JNK↑, p38↑, eff↓, *toxicity?,

3567-

MFrot,

MF,

The Effect of Extremely Low-Frequency Magnetic Field on Stroke Patients: A Systematic Review

Review,

Stroke,

*eff↑, *ROS↓, *Inflam↓, *cognitive↑, *Catalase↑, *SOD↑, *SOD1↑, *SOD2↑, *GPx1↑, *GPx4↑, *IL1β↑, *neuroP↑, *toxicity∅,

1273-

Myr,

Myricetin Induces Ferroptosis and Inhibits Gastric Cancer Progression by Targeting NOX4

vitro+vivo,

GC,

Ferroptosis↑, MDA↑, Iron↑, GSH↓, NOX4↑, NRF2↓, GPx4↓,

4927-

PEITC,

Targeting ferroptosis in osteosarcoma

Review,

OS,

AntiCan↑, BioAv↑, Ferroptosis↑, TfR1/CD71↑, Iron↑, ROS↑, MDA↑, lipid-P↑, GPx4↓,

2958-

PL,

Natural product piperlongumine inhibits proliferation of oral squamous carcinoma cells by inducing ferroptosis and inhibiting intracellular antioxidant capacity

in-vitro,

Oral,

HSC3

14.71 µM (48 hr),

TumCP↓, lipid-P↑, ROS↑, DNMT1↑, FTH1↓, GPx4↓, eff↓, GSH↓, Ferroptosis↑, MDA↓,

4965-

PSO,

Cisplatin,

The synergistic antitumor effects of psoralidin and cisplatin in gastric cancer by inducing ACSL4-mediated ferroptosis

vitro+vivo,

GC,

HGC27

2.5 to 120 µM)

Xenograft experiments in nude mice

vitro+vivo,

GC,

MKN45

TumCP↓, TumCMig↓, TumCI↓, TumCG↓, *toxicity↓, eff↑, Ferroptosis↑, ACSL4↑, GPx4↓, ChemoSen↑, chemoP↑, AntiTum↑, Sepsis↓,

5026-

QC,

Quercetin induces ferroptosis in gastric cancer cells by targeting SLC1A5 and regulating the p-Camk2/p-DRP1 and NRF2/GPX4 Axes

in-vitro,

GC,

SLC1A5↓, ROS↑, Iron↓, NRF2↓, GPx4↓, Ferroptosis↑,

1489-

RES,

Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer

Review,

Var,

RadioS↑, ChemoSen↑, *BioAv↓, *BioAv↑, Ferroptosis↑, lipid-P↑, xCT↓, GPx4↓, *BioAv↑, COX2↓, cycD1/CCND1↓, FasL↓, FOXP3↓, HLA↑, p‑NF-kB↓, BAX↑, Bcl-2↓, MALAT1↓,

3023-

RosA,

Rosmarinic acid alleviates septic acute respiratory distress syndrome in mice by suppressing the bronchial epithelial RAS-mediated ferroptosis

in-vivo,

Sepsis,

*GPx4↑, *Inflam↓, *ER Stress↓, *Ferroptosis↓, *Sepsis↓, *GRP78/BiP↓, *IRE1↓, JNK↓,

3039-

RosA,

Rosmarinic acid liposomes suppress ferroptosis in ischemic brain via inhibition of TfR1 in BMECs

in-vivo,

Nor,

mice

in-vivo,

Stroke,

*Ferroptosis↓, *GPx4↑, *ACSL4↓, *BBB↑, *IronCh↑, *TfR1/CD71↓, *neuroP↑,

4904-

Sal,

CUR,

Co-delivery of Salinomycin and Curcumin for Cancer Stem Cell Treatment by Inhibition of Cell Proliferation, Cell Cycle Arrest, and Epithelial–Mesenchymal Transition

CSCs↓, TumCCA↑, EMT↓, other↝, TumAuto↑, Iron↑, Ferroptosis↑, BioAv↓, ROS↑, lipid-P↑, GPx4↓, eff↑,

5139-

SAS,

Sulfasalazine induces ferroptosis in osteosarcomas by regulating Nrf2/SLC7A11/GPX4 signaling axis

in-vitro,

OS,

MG63

in-vitro,

OS,

U2OS

*Inflam↓, TumCP↓, TumCMig↓, Apoptosis↑, Ferroptosis↑, Iron↑, MDA↑, ROS↑, GSH↓, SOD↓, MMP↓, NRF2↓, xCT↓, GPx4↓, FTH1↓,

4613-

Se,

Rad,

Effect of Selenium and Selenoproteins on Radiation Resistance

Review,

Nor,

*selenoP↑, *GPx1↑, *GPx4↑, *lipid-P↓, *DNAdam↓, *ROS↓, *radioP↑,

1483-

SFN,

Targeting p62 by sulforaphane promotes autolysosomal degradation of SLC7A11, inducing ferroptosis for osteosarcoma treatment

in-vitro,

OS,

143B

0-10uM

in-vitro,

Nor,

HEK293

in-vivo,

OS,

25-50mg/kg

subcutaneous tumor-bearing nude mouse model

AntiCan↑, *toxicity∅, Ferroptosis↑, ROS↑, lipid-P↑, GSH↓, p62↑, SLC12A5↓, eff↓, GPx4↓, i-Iron↑, eff↓, MDA↑, TumVol↓, TumW↓, Ki-67↓, LC3B↑, *Weight∅,

3313-

SIL,

Silymarin attenuates post-weaning bisphenol A-induced renal injury by suppressing ferroptosis and amyloidosis through Kim-1/Nrf2/HO-1 signaling modulation in male Wistar rats

in-vivo,

NA,

50-100 mg/kg/day

Twenty-four male Wistar rats

*NRF2↑, *HO-1↑, *creat↓, *BUN↓, *RenoP↑, *MDA↓, *TNF-α↓, *IL1β↓, *Cyt‑c↓, *Casp3↓, *GSTs↓, *GSH↑, *GPx4↑, *SOD↑, *GSR↓, *Ferroptosis↓,

2201-

SK,

Shikonin promotes ferroptosis in HaCaT cells through Nrf2 and alleviates imiquimod-induced psoriasis in mice

in-vitro,

PSA,

HaCaT

in-vivo,

NA,

mice

*eff↑, *IL6↓, *IL17↓, *TNF-α↓, *lipid-P↑, *NRF2↓, *HO-1↝, *NCOA4↝, *GPx4↓, *Ferroptosis↓, *Inflam↓, *ROS↓, *Iron↓,

2200-

SK,

Shikonin inhibits the growth of anaplastic thyroid carcinoma cells by promoting ferroptosis and inhibiting glycolysis

in-vitro,

Thyroid,

CAL-62

1, 3 and 5 μM SKN for 24 h

in-vitro,

Thyroid,

8505C

NF-kB↓, GPx4↓, TrxR1↓, PKM2↓, GLUT1↓, Glycolysis↓, Ferroptosis↑, GlucoseCon↓, lactateProd↓, ROS↑,

2199-

SK,

Induction of Ferroptosis by Shikonin in Gastric Cancer via the DLEU1/mTOR/GPX4 Axis

in-vitro,

GC,

ROS↑, lipid-P↑, Iron↑, MDA↑, GPx4↓, Ferritin↓, DLEU1↓, mTOR↓, Ferroptosis↑,

2198-

SK,

Shikonin suppresses proliferation of osteosarcoma cells by inducing ferroptosis through promoting Nrf2 ubiquitination and inhibiting the xCT/GPX4 regulatory axis

in-vitro,

OS,

MG63

 0.75 uM, 1.5 uM and 3 uM

1.432 uM

in-vitro,

OS,

143B

1.638 uM

TumCP↓, TumCCA↑, Ferroptosis↑, Iron↑, ROS↑, lipid-P↑, MDA↑, mtDam↑, NRF2↓, xCT↓, GPx4↓, GSH/GSSG↓, Keap1↑,

2196-

SK,

Research progress in mechanism of anticancer action of shikonin targeting reactive oxygen species

Review,

Var,

*ALAT↓, *AST↓, *Inflam?, *EMT↑, ROS?, TrxR1↓, PERK↑, eIF2α↑, ATF4↑, CHOP↑, IRE1↑, JNK↑, eff↝, DR5↑, Glycolysis↓, PKM2↓, ChemoSen↑, GPx4↓, HO-1↑,

2195-

SK,

Shikonin induces ferroptosis in osteosarcomas through the mitochondrial ROS-regulated HIF-1α/HO-1 axis

in-vitro,

OS,

TumCP↓, Ferroptosis↓, Hif1a↑, HO-1↑, Iron↑, ROS↑, GSH/GSSG↓, GPx4↓,

2203-

SK,

Shikonin suppresses small cell lung cancer growth via inducing ATF3-mediated ferroptosis to promote ROS accumulation

in-vitro,

Lung,

TumCP↓, Apoptosis↓, TumCMig↓, TumCI↓, Ferroptosis↑, ERK↓, GPx4↓, 4-HNE↑, ROS↑, GSH↓, ATF3↑, HDAC1↓, ac‑Histones↑,

2202-

SK,

Enhancing Tumor Therapy of Fe(III)-Shikonin Supramolecular Nanomedicine via Triple Ferroptosis Amplification

in-vitro,

Var,

Iron↑, Ferroptosis↑, pH↝, H2O2↑, ROS↑, Fenton↑, GSH↓, GPx4↓, lipid-P↑,

1284-

SK,

Shikonin induces ferroptosis in multiple myeloma via GOT1-mediated ferritinophagy

in-vitro,

Melanoma,

RPMI-8226

in-vitro,

Melanoma,

U266

Ferroptosis↑, LDH↓, ROS↑, Iron↑, lipid-P↑, ATP↓, HMGB1↓, GPx4↓, MDA↑, SOD↓, GSH↓,

1068-

SM,

Danshen Improves Survival of Patients With Breast Cancer and Dihydroisotanshinone I Induces Ferroptosis and Apoptosis of Breast Cancer Cells

in-vitro,

BC,

MCF-7

5-10uM

in-vitro,

BC,

MDA-MB-231

in-vivo,

BC,

30 mg/kg, intraperitoneal injection

mouse

Human,

BC,

average clinical dose of danshen is 3 g per day for clinical Chinese medicine

TumCG↓, Ferroptosis↑, GPx4↓, TumVol↓, OS↑, GSH/GSSG↓,

4727-

SSE,

Selenium inhibits ferroptosis in ulcerative colitis through the induction of Nrf2/Gpx4

in-vivo,

Col,

experimental colitis in mice treated with dextran sulfate sodium (DSS)

*Ferroptosis↓, *NRF2↑, *GPx4↑, *eff↑, *other↓, *antiOx↑, *Inflam↓, AntiTum↑,

4723-

SSE,

Selenium Induces Ferroptosis in Colorectal Cancer Cells via Direct Interaction with Nrf2 and Gpx4

in-vitro,

CRC,

HCT116

TumCP↓, Iron↑, MDA↑, ROS↑, MMP↓, NRF2↓, GPx4↓, Ferroptosis↑,

4732-

SSE,

Selenium inhibits ferroptosis and ameliorates autistic-like behaviors of BTBR mice by regulating the Nrf2/GPx4 pathway

in-vivo,

Autism,

BTBR mice

*Ferroptosis↓, *NRF2↑, *GPx4↑, *other↝,

5091-

SSE,

Superoxide-mediated ferroptosis in human cancer cells induced by sodium selenite

in-vitro,

GBM,

U87MG

in-vitro,

Cerv,

HeLa

in-vitro,

BC,

MCF-7

in-vitro,

Pca,

PC3

in-vitro,

CRC,

HT-29

in-vitro,

Nor,

SVGp12

Ferroptosis↑, xCT↓, GSH↓, GPx4↓, Iron↑, lipid-P↑, ROS↑, eff↓, TumCP↓, TumCD↑,

5094-

SSE,

Sodium Selenite Prevents Matrine-Induced Nephrotoxicity by Suppressing Ferroptosis via the GSH-GPX4 Antioxidant System

vitro+vivo,

Nor,

NRK52E

explored the involvement of ferroptosis in MT-induced kidney injury and evaluated the potential efficacy and underlying mechanism of sodium selenite (SS) in attenuating MT-induced nephrotoxicity.

*GPx4↑, *xCT↑, *GSH↑, *RenoP↑,

5090-

SSE,

Sodium Selenite Induces Ferroptosis in Non-small Cell Lung Cancer A549 Cells Via Reactive Oxygen Species (ROS)/Glutathione (GSH)/Glutathione Peroxidase4 (GPx4) Axis

NA,

Lung,

A549

TumCP↓, ROS↑, GSH↓, MMP↓, GPx4↓, Iron↑,

5088-

SSE,

Superoxide-mediated ferroptosis in human cancer cells induced by sodium selenite

in-vitro,

BC,

MCF-7

in-vitro,

GBM,

U87MG

in-vitro,

Pca,

PC3

in-vitro,

Cerv,

HeLa

in-vitro,

GBM,

A172

Ferroptosis↑, ROS↑, Iron↑, xCT↓, GSH↓, GPx4↓, lipid-P↑, TumCP↓, selectivity↑,

5333-

TFdiG,

Theaflavin-3,3′-Digallate Plays a ROS-Mediated Dual Role in Ferroptosis and Apoptosis via the MAPK Pathway in Human Osteosarcoma Cell Lines and Xenografts

vitro+vivo,

OS,

MG63

tumCV↓, TumCP↓, TumCCA↑, Iron↑, ROS↑, GSH↓, Fenton↑, Ferroptosis↑, Apoptosis↑, MAPK↑, ERK↑, JNK↑, p38↑, TumCG↓, Dose↝, FTH1↓, GPx4↓,

3405-

TQ,

doxoR,

Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity and the underlying mechanism

vitro+vivo,

NA,

mice

*cardioP↑, *NRF2↑, *HO-1↑, *ROS↓, *NQO1↑, *COX2↓, *NOX4↓, *GPx4↑, *FTH1↑, *p‑mTOR↓, *TGF-β↓,

3399-

TQ,

Anticancer Effects of Thymoquinone through the Antioxidant Activity, Upregulation of Nrf2, and Downregulation of PD-L1 in Triple-Negative Breast Cancer Cells

in-vitro,

BC,

MDA-MB-231

NA,

BC,

MDA-MB-468

ROS↓, H2O2↓, Catalase↑, SOD↑, GSH↑, NQO1↑, GCLM↑, NRF2↑, PD-L1↓, GSSG↑, GPx1⇅, GPx4↓,

1215-

VitC,

immuno,

Metabolomics reveals ascorbic acid inhibits ferroptosis in hepatocytes and boosts the effectiveness of anti-PD1 immunotherapy in hepatocellular carcinoma

ex-vivo,

HCC,

in-vivo,

HCC,

mice

other↓, *GPx4↑, *GSH↑, GPx4↓, GSH↓, selectivity↑,

1216-

VitC,

Ascorbic acid induces ferroptosis via STAT3/GPX4 signaling in oropharyngeal cancer

in-vitro,

Laryn,

FaDu

in-vitro,

SCC,

SCC-154

Iron↝, ROS↑, tumCV↓, Ki-67↓, TumCCA↑, Ferroptosis↑, GSH↓, ROS↑, MDA↑, STAT3↓, GPx4↓, p‑STAT3↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 77

Pathway results for Effect on Cancer / Diseased Cells:

Infection & Microbiome ⓘ

Sepsis↓, 1,
Total Targets: 257

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

antiOx↑, 2, Catalase↑, 3, Ferroptosis↓, 7, GPx1↑, 6, GPx4↓, 1, GPx4↑, 14, GPx4∅, 1, GSH↑, 4, GSR↓, 1, GSTs↓, 1, HO-1↑, 2, HO-1↝, 1, HO-1∅, 1, Iron↓, 1, lipid-P↓, 2, lipid-P↑, 1, MDA↓, 2, NOX4↓, 1, NQO1↑, 1, NRF2↓, 1, NRF2↑, 6, NRF2∅, 1, OXPHOS↓, 2, ROS↓, 7, selenoP↑, 1, SOD↑, 3, SOD1↑, 4, SOD2↑, 2, xCT↑, 1,

Metal & Cofactor Biology ⓘ

FTH1↑, 1, IronCh↑, 1, NCOA4↝, 1, TfR1/CD71↓, 1,

Mitochondria & Bioenergetics ⓘ

mitResp↓, 1, MMP↝, 1,

Core Metabolism/Glycolysis ⓘ

ACSL4↓, 1, ACSL4∅, 1, ALAT↓, 1, BUN↓, 1, Glycolysis↑, 2, HK2↑, 2, PFKL↑, 2, PFKM↑, 2, PFKP↑, 1, PKM2↑, 2,

Cell Death ⓘ

Casp3↓, 1, Cyt‑c↓, 1, Ferroptosis↓, 7,

Transcription & Epigenetics ⓘ

other↓, 1, other↝, 2, tumCV↑, 1,

Protein Folding & ER Stress ⓘ

ER Stress↓, 1, GRP78/BiP↓, 1, IRE1↓, 1,

DNA Damage & Repair ⓘ

DNAdam↓, 1,

Proliferation, Differentiation & Cell State ⓘ

EMT↑, 1, p‑mTOR↓, 1,

Migration ⓘ

TGF-β↓, 1, TumCMig↑, 1,

Angiogenesis & Vasculature ⓘ

angioG↑, 1,

Barriers & Transport ⓘ

BBB↑, 1, GLUT1↑, 2, GLUT4↑, 1,

Immune & Inflammatory Signaling ⓘ

COX2↓, 1, IL17↓, 1, IL1β↓, 1, IL1β↑, 1, IL6↓, 1, Inflam?, 1, Inflam↓, 5, NF-kB↑, 1, TNF-α↓, 2,

Cellular Microenvironment ⓘ

pH↑, 1,

Drug Metabolism & Resistance ⓘ

BioAv↓, 1, BioAv↑, 3, Dose↝, 1, eff↑, 4,

Clinical Biomarkers ⓘ

ALAT↓, 1, AST↓, 1, creat↓, 1, IL6↓, 1,

Functional Outcomes ⓘ

cardioP↑, 1, cognitive↑, 1, hepatoP↑, 1, neuroP↑, 3, radioP↑, 1, RenoP↑, 2, toxicity?, 1, toxicity↓, 3, toxicity∅, 2, Weight∅, 1,

Infection & Microbiome ⓘ

Sepsis↓, 1,
Total Targets: 92

Scientific Paper Hit Count for: GPx4, Glutathione Peroxidase 4

9 Shikonin
7 Artemisinin
7 Selenite (Sodium)
6 Magnetic Fields
4 Curcumin
3 Baicalein
3 Honokiol
3 Vitamin C (Ascorbic Acid)
2 Astragalus
2 Ashwagandha(Withaferin A)
2 Radiotherapy/Radiation
2 Luteolin
2 Boron
2 Juglone
2 immunotherapy
2 Rosmarinic acid
2 Thymoquinone
1 Auranofin
1 Silver-NanoParticles
1 Andrographis
1 Docetaxel
1 Astaxanthin
1 Betulinic acid
1 Boswellia (frankincense)
1 Citric Acid
1 EGCG (Epigallocatechin Gallate)
1 erastin
1 HydroxyTyrosol
1 Metformin
1 Magnetic Field Rotating
1 Myricetin
1 Phenethyl isothiocyanate
1 Piperlongumine
1 Psoralidin
1 Cisplatin
1 Quercetin
1 Resveratrol
1 salinomycin
1 Sulfasalazine
1 Selenium
1 Sulforaphane (mainly Broccoli)
1 Silymarin (Milk Thistle) silibinin
1 Salvia miltiorrhiza
1 Aflavin-3,3′-digallate
1 doxorubicin

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:643  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

Database Query Results : , , GPx4

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

Metal & Cofactor Biology ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Kinase & Signal Transduction ⓘ

Transcription & Epigenetics ⓘ

Protein Folding & ER Stress ⓘ

Autophagy & Lysosomes ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Cellular Microenvironment ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Infection & Microbiome ⓘ

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

Metal & Cofactor Biology ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Transcription & Epigenetics ⓘ

Protein Folding & ER Stress ⓘ

DNA Damage & Repair ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Cellular Microenvironment ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Infection & Microbiome ⓘ

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