Database Query Results : , , PSMB5

PSMB5, proteasome subunit beta type-5: Click to Expand ⟱
Source:
Type:
PSMB5 is a gene that provides instructions for making a protein called proteasome subunit beta type-5. This protein is a part of the larger proteasome complex, which helps break down unneeded or damaged proteins in the cell.

PSMB5 is a key component of the proteasome complex whose altered expression or mutation plays an important role in cancer biology. In hematologic malignancies—especially multiple myeloma—elevated levels or mutant forms of PSMB5 are associated with resistance to proteasome inhibitors and poorer outcomes. In solid tumors, increased proteasome activity via PSMB5 may support tumor cell survival under proteotoxic and metabolic stress, although its prognostic value can be more variable.


Scientific Papers found: Click to Expand⟱
746- Bor,    Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope
- Review, NA, NA
eff↑, *toxicity↓, ROS↑, LAT↓, AntiCan↑, AR↓, PSMB5↓, IGF-1↓, PSA↓, TumVol↓, eff↑, Rho↓, Cdc42↓, Ca+2↓, eff↑,
415- CUR,    Curcumin inhibits proteasome activity in triple-negative breast cancer cells through regulating p300/miR-142-3p/PSMB5 axis
- vitro+vivo, BC, MDA-MB-231
PSMB5↓, CT-I↓, miR-142-3p↑, EP300↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

ROS↑, 1,  

Core Metabolism/Glycolysis ⓘ

LAT↓, 1,   PSMB5↓, 2,  

Proliferation, Differentiation & Cell State ⓘ

EP300↓, 1,   IGF-1↓, 1,   miR-142-3p↑, 1,  

Migration ⓘ

Ca+2↓, 1,   Cdc42↓, 1,   Rho↓, 1,  

Immune & Inflammatory Signaling ⓘ

PSA↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

CT-I↓, 1,   eff↑, 3,  

Clinical Biomarkers ⓘ

AR↓, 1,   PSA↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   TumVol↓, 1,  
Total Targets: 17

Pathway results for Effect on Normal Cells:


Functional Outcomes ⓘ

toxicity↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: PSMB5, proteasome subunit beta type-5
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:649  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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