Database Query Results : , , CT-I

CT-I, Chymotrypsin-like (CT-l) activity: Click to Expand ⟱

Source:

Type:

Chymotrypsin-like (CT-l) activity is a type of protease activity that is associated with certain types of cancer. Proteases are enzymes that break down proteins, and CT-l activity is a measure of the level of this type of protease activity in a given sample.
CT-l activity is often elevated, and this has been linked to a number of negative outcomes, including increased tumor growth and metastasis. As a result, CT-l activity is often used as a biomarker for cancer, and it may also be a target for cancer therapy.

Scientific Papers found: Click to Expand⟱

415-

CUR,

Curcumin inhibits proteasome activity in triple-negative breast cancer cells through regulating p300/miR-142-3p/PSMB5 axis

vitro+vivo,

BC,

MDA-MB-231

5, 10, 20 and 50 μM, 24 h; 25 g/kg, 4 weeks

mice

PSMB5↓, CT-I↓, miR-142-3p↑, EP300↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis ⓘ

PSMB5↓, 1,

Proliferation, Differentiation & Cell State ⓘ

EP300↓, 1, miR-142-3p↑, 1,

Drug Metabolism & Resistance ⓘ

CT-I↓, 1,
Total Targets: 4

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: CT-I, Chymotrypsin-like (CT-l) activity

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells